PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0007102|colon cancer |
| Sentences | 5 |
| PubMedID- 21269976 | Conclusion: cocl(2) can simulate hypoxia in colon cancer cells in vitro to induce stable hif-1alpha expression, which is concentration- and time-dependent. |
| PubMedID- 22687485 | In ht-29 human colon cancer cells treated with a hypoxia-inducing agent (cocl(2)), lyr-8 dose-dependently suppressed the induction of hif-1alpha and subsequently its targets, vegf and cox-2. |
| PubMedID- 24609463 | For example, hypoxia in colon cancer cell lines affects apc levels via a direct effect of hypoxia inducible factors (hifs) at the apc promoter (30). |
| PubMedID- 26251616 | Here, we found that hif-1alpha and the drug resistance-associated gene multidrug resistance associated protein 1 (mrp1) were induced by treatment of colon cancer cells with the hypoxia-mimetic agent cobalt chloride. |
| PubMedID- 24932611 | Treatment of hct-116 and caco-2 colon cancer cells with the hypoxia mimic cocl2 induced the formation of cells with larger cell and nuclear size (pgccs), while the cells with normal morphology were selectively eliminated. |
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