PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0006142|breast cancer |
| Sentences | 19 |
| PubMedID- 25932043 | She studied the role of hypoxia in breast cancer and used breast cancer cell lines with distinct aggressiveness properties to develope an innovative strategy based on a system-wide quantitative proteomics in combination with a high-throughput migration screen and protein network analysis. |
| PubMedID- 24517586 | Among the positively correlated micrornas to hypoxia in breast cancer (spearman rank test, adj.p-val ≤ 0.05), there are two micrornas that overlap with our list of hypoxia induced micrornas: hsa-mir-210-3p and hsa-mir-27a-3p, which is derived from the mir27a cluster (see table 3). |
| PubMedID- 23696831 | Methods and results: ddx3 expression was investigated by immunohistochemistry in breast cancer in comparison with hypoxia related proteins hif-1alpha, glut1, caix, egfr, her2, akt1, foxo4, p53, eralpha, commd1, fer kinase, pin1, e-cadherin, p21, p27, transferrin receptor, foxo3a, c-met and notch1. |
| PubMedID- 21319150 | Conclusions: evidence was provided for an association of lamp3 with tumor cell hypoxia in breast cancer xenografts. |
| PubMedID- 22028862 | Whether this suppression is a direct p53-related consequence that, as recently observed in breast cancer, also leads to hypoxia inducible factor (hif) 1 alpha accumulation, is currently not known [40]. |
| PubMedID- 20010940 | Snail expression was increased significantly in mda-468 and t47d breast cancer cells with hypoxia, and this increase was abrogated by gsi treatment (figure 6a). |
| PubMedID- 20436681 | We compared mir-210 expression in our published series of breast cancer [14] with our hypoxia metagene of clustered mrnas [25] and combined assessment with target prediction algorithms showed iscu was the highest predicted target, and three known target genes also sit in highly-ranked positions were selected by this approach (supporting material and methods s1, supporting table s1). |
| PubMedID- 25988385 | Simultaneous treatment of mcf7 and sum52pe breast cancer cells with acidosis and hypoxia may induce the expression of inflammatory response genes such as tumor necrosis factor alpha (tnf-α) and tumor necrosis factor alpha-induced protein 3 (tnfaip3) [109]. |
| PubMedID- 24461075 | Here we report that targeting breast cancer cells with the hypoxia-activated drug, dcq, reduces hypoxia-induced emt, as indicated by the reduction of hypoxia-induced cell migration in mcf-7 cells and downregulation of twist in mda-mb-231. |
| PubMedID- 24216987 | Currently, many studies focus on and discuss mechanisms of tumor hypoxia in breast cancer at the transcriptomic level. |
| PubMedID- 25587023 | Intratumoral hypoxia, which is associated with breast cancer metastasis and patient mortality, increases the percentage of breast cancer stem cells (bcscs) but the underlying molecular mechanisms have not been delineated. |
| PubMedID- 24349381 | To the best of our knowledge, this study is the first to report that nmbr is hypoxia-responsive in breast cancer cells and to elucidate the mechanisms underlying its regulation. |
| PubMedID- 24799675 | Triple-negative breast cancers have increased expression of genes regulated by hypoxia-inducible factors (hifs). |
| PubMedID- 25929338 | The aim of this current study was to examine the association of endocrine resistance in human breast cancer with hypoxia and its major regulator, hif-1α, in vivo. |
| PubMedID- 26536104 | As with breast cancer cells, expression of iscu1/2 was not hypoxia-dependent. |
| PubMedID- 21875443 | Gene expression and hypoxia in breast cancer. |
| PubMedID- 21306611 | hypoxia in breast cancer has profound effects on tumor biology that are reflected in a poor prognosis and resistance to both chemotherapy and radiotherapy in patients [1]. |
| PubMedID- 22921864 | breast cancers contain regions of intratumoral hypoxia in which reduced o(2) availability activates the hypoxia-inducible factors hif-1 and hif-2, which increase the transcription of genes encoding proteins that are required for many important steps in cancer progression. |
| PubMedID- 22031289 | Nodal is regulated by hypoxia in breast cancer, melanoma, and human embryonic stem cell lines. |
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