PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0002871|anemia |
| Sentences | 12 |
| PubMedID- 23343462 | Iron deficiency and hypoxia resulting from anemia can induce maternal and fetal stress thus increasing norepinephrine concentration. |
| PubMedID- 21348606 | Treatment of spleen macrophages or hs-p cells cocultured with ils with cobalt chloride, which mimics the effects of anemia-induced hypoxia, led to downregulation of m-csf mrna levels, upregulation of gm-csf and mif, and an increase in phagocytic activity. |
| PubMedID- 24320974 | It has also been reported that greater variation in rdw is associated with impaired blood flow through the microvascular system, which may cause tissue hypoxia, even in patients without anemia [48]. |
| PubMedID- 20585586 | Our present study suggests a model where, in response to acute anemia, expansion of the hypoxia zone in the liver acini leading to an expansion of hif2α dependent expression of bmp4[40]. |
| PubMedID- 25121095 | The first one is chronic hypoxia resulting from chronic anemia and ineffective erythropoiesis leading to mitochondrial damage and the second is iron overload also due to chronic anemia and tissue hypoxia leading to increase intestinal iron absorption in thalassemic patients. |
| PubMedID- 22438739 | The main function of hemoglobin is to carry oxygen from the lungs to the tissues, so anemia leads to hypoxia (lack of oxygen) in organs. |
| PubMedID- 26124994 | Some reports suggest that anemia is due to hypoxia which increases oxidative stress, thus enhancing tissue injury [15]. |
| PubMedID- 25710019 | Increased rdw is associated with impaired microvascular perfusion, causing hypoxia even in patients without anemia [57]. |
| PubMedID- 23495280 | It impairs the ability of hemoglobin to transport oxygen, produces functional anemia, and leads to tissue hypoxia which can be fatal if severe. |
| PubMedID- 25738478 | Most of the heme synthesis in the body takes place in the bone marrow erythroid cells and most of the remaining part is in the liver hepatocytes and other heme-synthesizing cells.9 inadequate heme/hgb synthesis (the effect of chronic anemia) leads to inadequate oxygenation (hypoxia), which, in turn, causes growth retardation with inadequate function in many tissues. |
| PubMedID- 22355626 | Cellular hypoxia may result from anemia, from pulmonary, cardiac micro-and macrovascular pathology, or from abnormal oxygen handling. |
| PubMedID- 23737836 | Failure to increase the amount of circulating epo under hypoxia stress can lead to anemia [8]. |
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