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PedAM

Pediatric Disease Annotations & Medicines




Disease anoxia
Phenotype C0001125|lactic acidosis
Sentences 9
PubMedID- 25607274 The result is severetissue hypoxia, with lactic acidosis and increased central venous oxygen saturation.the lactate levels are correlated with the severity of poisoning.
PubMedID- 22568883 In most of the cases, drug use is only coincidental and lactic acidosis is due to concomitant hypoxia, tissue hypoperfusion or liver failure (metformin-associated lactic acidosis) [6].
PubMedID- 23044498 Immediately after coronary artery bypass graft (cabg) surgery, patients are haemodynamically unstable and need fluid support.1 the purpose of using volume expanders after cardiac bypass surgery is to maintain stable haemodynamics.2 applying an appropriate fluid with enough volume at this stage may prevent systemic hypoperfusion and cellular hypoxia, which lead to systemic lactic acidosis.3 furthermore, after cardiopulmonary bypass patients experience systemic inflammatory responses and endothelial damage, which lead to fluid extravasations and interstitial oedema.
PubMedID- 24994076 Key message: these results suggest that use of inhibitors of nhe1 might be worthwhile in the treatment of some types of acute metabolic acidosis, specifically the lactic acidosis associated with hypoxia, hemorrhagic shock, and cardiac arrest.
PubMedID- 26236720 We found that alkalization of the dialysis fluid enhances lactate removal in animals with lactic acidosis due to hypoxia [52].
PubMedID- 25887061 However, only the association of hypoxia with intracellular lactic acidosis induces the activation of the death pathway (lam) [42].
PubMedID- 20838762 During asphyxia, a severe arterial and tissue hypoxia with hypercapnia and lactic acidosis quickly developed.
PubMedID- 22135092 In contrast, lactic acidosis strongly synergized with hypoxia to activate the unfolded protein response (upr) and an inflammatory response, displaying a strong similarity to atf4-driven amino acid deprivation responses (aar).
PubMedID- 24601179 Patients with lactic acidosis show commonly signs of shock, tissue hypoxia, acute hepatic or renal failure and the link between metformin therapy and lactic acidosis may be coincidental, associated or causal.

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