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PedAM

Pediatric Disease Annotations & Medicines




Disease anemia, megaloblastic
Phenotype C0016412|folate deficiency
Sentences 6
PubMedID- 26576179 Folic acid is not stored in the human body in large quantities, and even short durations of inadequate intake or malabsorption can cause folate deficiency, leading to megaloblastic anemia25).
PubMedID- 24298825 folate deficiency is associated with hyperhomocysteinemia, megaloblastic anemia, leuco- and thrombocytopenia, cardiovascular disease, embryonic defects, in particular neural tube defects, and, possibly, malignancies, depression and cognitive impairment.
PubMedID- 25733650 The reduction in rbc counts, hematocrit, and hemoglobin because of fasd and genotype and the larger mean corpuscular volume because of fasd are reminiscent of the megaloblastic anemia associated with folate deficiency.
PubMedID- 26300625 Background: folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia.
PubMedID- 25763532 Folate: folate deficiency leading to megaloblastic anemia is the second most common cause of anaemia during pregnancy [23].
PubMedID- 23687454 Prolonged folate deficiency leads to megaloblastic anemia, which can result in increased levels of serum homocysteine concentrations in adults and neural tube defects in the fetus.

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