PedAM
Pediatric Disease Annotations & Medicines
| Disease | alcohol abuse |
| Phenotype | C0007222|cardiovascular disease |
| Sentences | 1 |
| PubMedID- 22661894 | Consistent evidence associates increased circulating serum gamma-glutamyltransferase (ggt), a parameter conventionally used for diagnosing hepatobiliary diseases and alcohol abuse,1 with incident cardiovascular disease (cvd)2 and major proatherogenic risk factors.3 for this reason, ggt determination has been added to the array of biomarkers useful for stratifying cardiometabolic risk.4 furthermore, the enzyme’s active involvement in the atherogenic process was hypothesized on the basis of its potential to increase the intracellular prooxidant burden through the iron-reducing properties of cysteinylglycine moieties generated during ggt-catalyzed glutathione hydrolysis.5 the identification of prooxidant ggt activity in atheromatous plaques of carotid and coronary arteries6 adds to the need for further clinical evaluation. |
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