PedAM

Pediatric Disease Annotations & Medicines

Disease	adenoma
Phenotype	C0001206\|acromegaly
Sentences	14
PubMedID- 22802758	acromegaly in couse of pituitary adenoma was diagnosed based on the typical clinical presentation and results of laboratory tests.
PubMedID- 24101276	acromegaly associated with mixed pituitary adenoma-gangliocytoma and rathke's cleft cyst.
PubMedID- 24119925	Ectopic acromegaly due to a gh-secreting adenoma arising from abnormally located pituitary tissue is an extremely rare entity; barely cases have been reported in the literature in the past 30 years (table 2).
PubMedID- 22364960	Design: we report the complex clinical presentation of the unique case, never described, of acromegaly due to gh-secreting pituitary adenoma associated with jak2 v617f mutation.
PubMedID- 22220234	Physical examination revealed acromegaly due to the pituitary adenoma (height 191 cm, weight 104 kg) and the mallampati class was 2. preoperative vital signs showed blood pressure at 120/80 mmhg and heart rate at 72 bpm.
PubMedID- 23593161	Neurocognitive function in acromegaly after surgical resection of gh-secreting adenoma versus naive acromegaly.
PubMedID- 25890363	Therefore, they meet the established diagnostic guidelines and were diagnosed with carney complex.table 3diagnostic criteria for carney complexdiagnostic criteriamajor criteriaskin pigmentation disorders 1. spotty skin pigmentation with a typical distribution (lips, conjunctiva and inner or outer canthi, vaginal, and penile mucosa) 2. blue nevus, epithelioid blue nevus (multiple)myxomas 1. myxoma (cutaneous and mucosal) 2. cardiac myxoma 3. breast myxomatosis or fat-suppressed magnetic resonance imaging findings suggestive of this diagnosis 4. osteochondromyxomaendocrine tumors/overactivity 1. ppnad or paradoxical positive response of urinary glucocorticosteroids to dexamethasone administration during liddle’s test 2. acromegaly due to gh-producing adenoma 3. lccsct or characteristic calcification on testicular ultrasonography 4. thyroid carcinoma or multiple, hypoechoic nodules on thyroid ultrasonography, in a young patient 5. psammomatous melanotic schwannoma 6. breast ductal adenoma (multiple)supplemental criteria1.
PubMedID- 25238988	Background: despite the wide spectrum of adenoma behavior in patients with acromegaly, the ability of most pathological markers to predict clinical and radiological behavior remains controversial.
PubMedID- 25210615	The association of conn's adenoma with acromegaly has been interpreted in two lines: as a component of multiple endocrine neoplasia type (men1) syndrome or as a direct mitogenic effect of hyperactivated gh-igf1 axis.
PubMedID- 26354069	Endocrine manifestations of cnc include pituitary adenoma with acromegaly, thyroid tumors, testicular large cell calcifying sertoli cell tumors (lccscts), ovarian lesions, and primary pigmented nodular adrenal disease (ppnad).
PubMedID- 21744088	Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: sstr5 polymorphism and pkd1 mutation.
PubMedID- 22029034	acromegaly with no pituitary adenoma and no evidence of ectopic source.
PubMedID- 24558895	Transsphenoidal surgery is the treatment of choice for acromegaly due to pituitary adenoma but it is not always possible to reduce or control tumor growth, inhibit gh hypersecretion and normalize igf-i.
PubMedID- 23315333	Differential diagnosis includes syndromes that present with multiple endocrine neoplasias, like men syndromes (thyroid, pituitary and adrenal involvement), or with similar manifestations from skin, bones and other tissues, like peutz-jeghers syndrome (lentigines), mccune-albright syndrome (cafe-au-lait spots, bone tumours, pituitary and adrenal involvement) and others.table 1diagnostic criteria for cnc (from [5] with written permission)diagnostic criteria for cnc• spotty skin pigmentation with a typical distribution (lips, conjunctiva and inner or outer canthi, vaginal and penile mucosa)• myxoma (cutaneous and mucosal)a• cardiac myxomaa• breast myxomatosisa or fat-suppressed mri findings suggestive of this diagnosis• ppnadaor paradoxical positive response of urinary glucocorticosteroids to dexamethasone administration during liddle’s test• acromegaly due to gh-producing adenomaa• lccsctaor characteristic calcification on testicular ultrasonography• thyroid carcinoma (at any age)aor multiple, hypoechoic nodules on thyroid ultrasonography in a prepubertal child• psammomatous melanotic schwannomaa• blue nevus, epithelioid blue nevus (multiple)a• breast ductal adenoma (multiple)a• osteochondromyxomasupplemental criteria:1. affected first-degree relative2.

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