PedAM
Pediatric Disease Annotations & Medicines
| Disease | acute pancreatitis |
| Phenotype | C1565489|renal insufficiency |
| Sentences | 1 |
| PubMedID- 24644425 | Metformin, the first-line oral therapies for type 2 diabetes, has been used in clinical application since 1950s 1. metformin functions mainly in insulin-targeted tissues such as liver, muscle, and adipose tissues, and activation of the amp-activated protein kinase (ampk) by metformin suppresses hepatic glucose production and increases glucose utilization 1. in addition to regulation of metabolism, metformin exerts a protective effect on cardiovascular disease 2 and various cancers 3. however, metformin induces acute pancreatitis specifically in patients with renal insufficiency 4. in addition, overactivation of ampk by metformin impairs the ability of neurons to grow output stalks or axons in animal models 5 thus may exert in alzheimer's disease 6. thus, further research is warranted to understand the complex nature of metformin action and the drug safety. |
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