PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | |cleft palate |
| Sentences | 332 |
| PubMedID- 20436469 | A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near mafb and abca4. |
| PubMedID- 19737740 | Background: non-syndromic isolated cleft lip with or without cleft palate (ncl/p) is a common congenital anomaly in humans, the aetiology of which is complex and associated with both genetic and environmental factors. |
| PubMedID- 25745610 | cleft lip associated with cleft palate (clp) was the most prevalent type of cleft (50%), followed by isolated cleft lip (35.2%) and isolated cleft palate (14.8%). |
| PubMedID- 22182590 | Nonsyndromic cleft lip with or without cleft palate (nsclp [mim 119530]) is one of the most common human craniofacial birth defects, with both genetic and environmental components involved in its etiology [1]. |
| PubMedID- 22286446 | Having a cleft lip together with cleft palate was associated with fistula formation, whereas surgeon nationality and older age at surgery were not. |
| PubMedID- 23091646 | cleft lip with or without cleft palate (clp) and cleft palate only (cpo) are among the most frequent birth defects in humans, affecting 1–2 per thousand newborns [1], [2], [3], [4]. |
| PubMedID- 20210635 | Objective: to delineate inherent differences in the microbial milieu in cleft palate patients compared with cleft lip patients and to document changes in microbial flora before and after cleft lip and palate repair. |
| PubMedID- 21254358 | Background: nonsyndromic cleft lip with or without cleft palate (nsclp) is a common birth defect that has a multifactorial etiology. |
| PubMedID- 21989583 | Nonsyndromic cleft lip with or without cleft palate or isolated cleft palate show an incomplete separation of the oral cavity and the nasal space without any additional malformations. |
| PubMedID- 23799041 | Crispld2 plays a role in the development of rat lung and mouse kidney and is also involved in the development of nonsyndromic cleft lip with or without cleft palate [24]–[28]. |
| PubMedID- 21781438 | In the present investigation tfap2a has been considered a good candidate gene for nonsyndromic cleft lip with or without cleft palate (nsclp) aetiology, basing on a sum of considerations. |
| PubMedID- 21728810 | Introduction: branchio-oculo-facial syndrome (bofs) is a rare autosomal dominant congenital disorder defined by branchial defects, ocular anomalies and craniofacial malformations, including variable degrees of cleft lip with or without cleft palate. |
| PubMedID- 20924451 | [1] the prevalence per 1000 total birth of cleft lip and/or with cleft palate ranges from around two in mongoloid populations to about 0.5 in negroid groups, and in caucasian populations the prevalence is about 1.2 per 1000 total birth. |
| PubMedID- 22138420 | Background: peri-conceptional use of folic acid contributes to protection against congenital malformations, such as neural tube defects and cleft lip with or without cleft palate (cl/p). |
| PubMedID- 23304489 | All new cases of cleft lip, with cleft palate associated and cleft palate isolated from patients under one year of age, were included in this study. |
| PubMedID- 20103790 | Detection rates between both health insurance schemes (public and nonpublic) did not show significant differences, but anencephaly, spina bifida, renourinary defects, and cleft lip with or without cleft palate were detected earlier in patients from nonpublic rather than in public hospitals. |
| PubMedID- 20815715 | Unilateral cleft lip with cleft palate (41%) was the most frequent cleft subtype, followed by cleft lip and/or cleft alveolus (33%); isolated submucous cleft palate (1%) was the least frequent. |
| PubMedID- 23162980 | cleft palate in the absence of a cleft lip (i.e. |
| PubMedID- 24800624 | Findings from random effects meta-analyses suggest no relationship between prenatal alcohol consumption and the occurrence of ofcs {pooled odds ratios for any alcohol intake and binge level drinking respectively: cleft lip with or without cleft palate 1.00 [95% confidence interval (ci) 0.86, 1.16] from 18,349 participants in 13 studies, 1.04 [95% ci 0.87, 1.24] [8763 individuals, 4 studies]; cleft palate only 1.05 [95% ci 0.92, 1.21] [21,459 individuals, 17 studies], 0.94 [95% ci 0.74, 1.21] [7730 participants, 4 studies]}. |
| PubMedID- 25535458 | Results: the difference in median cleft lip with or without cleft palate among the three groups was significant. |
| PubMedID- 21536809 | Main outcome measures: pnd and birth prevalence of selected congenital anomaly groups/subtypes (anencephaly, spina-bifida, serious cardiac, diaphragmatic hernia, gastroschisis, exomphalos, bilateral renal agenesis, lethal/severe skeletal dysplasia, cleft lip with or without cleft palate [cl + /- p]). |
| PubMedID- 26023668 | [1], the estimated incidence of cleft lip with cleft palate (clp) in the united states was 10.5 per 10,000 live births and that of cpo was 6.4 per 10,000 live births. |
| PubMedID- 23031822 | The only exception was associations between heat waves and cleft lip with or without cleft palate that varied significantly by ethnicity: hispanic (aor = 3.02; 95% ci: 1.44, 6.33) versus non-hispanic (aor = 0.83; 95% ci: 0.67, 1.05). |
| PubMedID- 22737550 | Background: non-syndromic cleft lip with or without cleft palate (cl/p) or cleft palate only (cpo) are orofacial clefts with multifactorial etiology. |
| PubMedID- 23642423 | Objective: cleft lip with or without cleft palate (cl+/-p) or cleft palate (cp) are groups of malformations named orofacial clefts (oc), which are the second leading cause of birth defects. |
| PubMedID- 23150817 | cleft lip with or without cleft palate is major structural birth defect that represents a serious public health problem. |
| PubMedID- 24339768 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is the most common congenital craniofacial defect [3], [16], [17]. |
| PubMedID- 20662919 | Non-syndromic cleft lip with or without cleft palate (nsclp) is the most common craniofacial birth defect. |
| PubMedID- 22682069 | cleft lip with or without cleft palate (clp), or cleft palate alone (cp) are the most frequent cranio-facial malformations in humans. |
| PubMedID- 20723211 | The risk of a cleft lip with or without cleft palate was increased by a factor of almost two. |
| PubMedID- 22288914 | Genotype and haplotype analysis of wnt genes in non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 20500065 | Results: we report the second case of 3q29 microdeletion syndrome including cleft lip with or without cleft palate and the first case of this microdeletion syndrome inherited from a phenotypically normal mosaic parent. |