PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | |cleft palate |
| Sentences | 332 |
| PubMedID- 24941352 | Results and conclusions : rates for cleft lip with or without cleft palate and cleft palate only have been very stable over the 33-year period (1980 through 2011). |
| PubMedID- 20587169 | cleft lip (with or without cleft palate) has been documented in several species of nonhuman primates, which in general are susceptible at similar doses and stages of gestation to the same teratogens as humans. |
| PubMedID- 25135242 | Background: cleft lip with or without cleft palate is one of the most common congenital anomalies that affect the oro-facial region. |
| PubMedID- 24563486 | The most frequent forms are nonsyndromic cleft lip with or without cleft palate (nscl/p) and nonsyndromic cleft palate only (nscpo). |
| PubMedID- 20946971 | Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (cl/p) in europe. |
| PubMedID- 20418035 | Fetal cleft lip with and without cleft palate: comparison between mr imaging and us for prenatal diagnosis. |
| PubMedID- 21423016 | Probandwise concordance rates and heritability for twins were estimated for 2 phenotypes--cleft lip with or without cleft palate (cl/p) and cleft palate (cp). |
| PubMedID- 24606907 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is a common structural malformation with a complex and multifactorial aetiology. |
| PubMedID- 21834040 | Contribution of variants in and near the irf6 gene to the risk of nonsyndromic cleft lip with or without cleft palate in a malay population. |
| PubMedID- 24400297 | Reported etiologies of non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 20738159 | However, rarely studies have linked sumo1 to nonsyndromic cleft lip with or without cleft palate in humans. |
| PubMedID- 24743817 | Objective: to analyze the minor allele frequencies (mafs), haplotype block and haplotype frequencies for single nucleotide polymorphisms (snps) in sumo1 using hapmap data and perform association analysis between snps in sumo1 and non-syndromic cleft lip with or without cleft palate (nscl/p) using 183 trios recruited from shandong province. |
| PubMedID- 25155265 | Recently, the jumoji at-rich interaction domain 2 (jarid2) had been reported to be a novel candidate gene for non-syndromic cleft lip with or without cleft palate (cl/p). |
| PubMedID- 24303408 | The study by vallino-napoli and colleagues in australia between 1983 and 2000 reported that when cleft lip with and without cleft palate was considered as one group, the data showed a significantly increased adjusted odds ratio (or=51.63, 95% ci [51.1, 2.5]) for women who were 40 years old, compared with all other ages (26). |
| PubMedID- 23081944 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is one of the most common of all congenital anomalies, and has a multifactorial etiology involving both environmental and genetic factors. |
| PubMedID- 25444729 | cleft lip with or without cleft palate is the most common congenital malformation of the head and neck. |
| PubMedID- 23664420 | There is increasing evidence that dietary folic acid deficiency in utero may increase the risk of developing the 'cleft lip with or without cleft palate' (cl+/-p) variant of orofacial cleft. |
| PubMedID- 20932509 | Objective: non-syndromic cleft lip with or without cleft palate (nsclp) is one of the most common birth defects all over the world. |
| PubMedID- 24799419 | Evidence from biological and human studies strongly supports a role for mmp and mp genes as candidate genes for non-syndromic cleft lip with or without cleft palate (nscl/p). |
| PubMedID- 25768737 | Orofacial clefts are broadly divided into cleft lip with or without cleft palate and cleft palate only [8]. |
| PubMedID- 26082386 | Dental anomalies were more prevalent in cleft lip with cleft palate than other cleft types. |
| PubMedID- 20531946 | Four congenital birth defects were diagnosed in neonates born from mother reporting ili during pregnancy, one in the pdm flu group (ventricular septal defect, n = 1), three in the non pdm ili group (cleft lip without cleft palate, n = 1, cleft lip with cleft palate, n = 1, hypospadias, n = 1). |
| PubMedID- 25662552 | The 50% concordance rate of mono zygotic twins for cleft lip with or without cleft palate (cl/p) and cleft palate (cp) showed that both genetic and environmental exposures could alter susceptible risk of nsocs, while the probandwise concordance rate was higher for cl/p and cp for mono zygotic twins than dizygotic twins, implied a strong genetic component, which promoted the discovery of the candidate genes (4-9). |
| PubMedID- 23056376 | In addition to spina bifida, previous studies found significant associations between antiepileptics exposure and cardiac defects, cleft lip with or without cleft palate, hypospadias, anomalies of brain, anomalies of circulatory system, limb reduction defects, and hypertelorism [14]; and between antiepileptics exposure and hypospadias, cleft lip with or without cleft palate, polydactyly, cardiac outflow tract defects, cleft palate, limb deficiency, atrial septal defect, and craniosynostosis using oeca design [11]. |
| PubMedID- 19536562 | These heterogeneous defects comprise cleft lip (cl), cl with cleft palate (cl/p), and cleft palate, sometimes observed in recognizable syndromes, with mendelian, chromosomal, or environmental pathogenesis. |
| PubMedID- 24524080 | Abnormal metabolism of hcy is related to many diseases, such as congenital heart disease [5], cleft lip with or without cleft palate [4], and ntds [6]. |
| PubMedID- 21431856 | Our aim was to evaluate whether the transcription factor hand2 could be implicated in non-syndromic cleft lip with or without cleft palate (cl/p) aetiology. |
| PubMedID- 22302702 | Patients were classified in two distinct groups: cleft lip with or without cleft palate (cl +/- p) and isolated cleft palate (cp). |
| PubMedID- 19691087 | cleft lip with or without cleft palate showed a different pattern by gender, urban-rural classification, and geographic location when compared to cleft palate, particularly for nonsyndromic cases. |
| PubMedID- 26034714 | The face revealed low set ears, hazy corneas, and bilateral complete cleft lip with complete cleft palate (fig. |
| PubMedID- 21911986 | Almost two-thirds of craniofacial patients had associated deformities of cleft lip with or without cleft palate (clp). |
| PubMedID- 23371247 | Risk for birth defects was substantially increased among some obese mothers (bmi >/=30) (e.g., spina bifida, tetralogy of fallot, cleft lip with or without cleft palate, hypospadias, and epispadias). |
| PubMedID- 24652124 | Association between palatal index and cleft palate repair outcomes in patients with complete unilateral cleft lip and palate. |
| PubMedID- 24710215 | Further inclusion criteria were 1) cleft lip with or without cleft palate; 2) sample size larger than 10 for at least one cleft type; 3) patients 5 years of age or older; and 4) publications with quantitative assessment. |
| PubMedID- 26215833 | The purpose of the study was to analyse polymorphic variants of the gch1 gene as risk factors for non-syndromic cleft lip with or without cleft palate (nscl/p). |
| PubMedID- 22346004 | The major symptoms include palmoplantar hyperkeratosis, sparse, coarse, wiry hair, small, sparse eyelashes, malformed nails, missing teeth (anodontia/oligodontia), cleft palate, sometimes with cleft lip and lid adhesions/ankyloblepharon. |
| PubMedID- 20815724 | Crispld2 variants including a c471t silent mutation may contribute to nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 22879780 | cleft lip (with or without cleft palate) is the most commonly reported congenital anomaly requiring surgery, occurring at a rate of 79.1 per 100,000 live births.1 in california, the incidence of cleft lip (with or without cleft palates) is 74.1 per 100,000 live births.2 this congenital malformation is referred to pediatric plastic surgeons and requires early repair for functional, esthetic, and psychosocial reasons. |
| PubMedID- 26451072 | Methods: we used a population-based sample of 377 case-parent trios of cleft lip with or without cleft palate (cl/p) and 762 control-parent trios from norway (1996-2001) to investigate whether variants in gabbr2, ddc and chrna4 are associated with maternal first-trimester smoking and with clefting risk. |
| PubMedID- 23136939 | There was a statistically significant adjusted exposure-response relationship for cleft lip with or without cleft palate (ptrend = .02). |
| PubMedID- 25793997 | Orofacial clefts (ofcs), including cleft lip with or without cleft palate (cl/p) and cleft palate only (cpo), are commonly occurring human birth defects that cause significant morbidity and require extensive medical intervention. |
| PubMedID- 23514444 | Orofacial clefts included cleft lip without cleft palate, cleft lip with cleft palate, cleft palate, and cleft lip with or without cleft palate. |
| PubMedID- 20949503 | Clinical features include short stature, hypertelorism, low set ears, cleft lip with cleft palate, short neck, truncus arteriosus, micropenis, clubfoot, over riding toes on right foot, four digits on left foot and growth delay. |
| PubMedID- 22851992 | [10] for the role of pvrl1 in cleft lip with or without cleft palate. |
| PubMedID- 25593972 | Second, to conduct a similar analysis per cleft type: cleft lip with or without cleft palate (cp), cp (including robin sequence). |
| PubMedID- 22887353 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is one of the most common congenital anomalies, with a complex and still not fully understood etiology. |
| PubMedID- 26064247 | Gfa taq i polymorphism and cleft lip with or without cleft palate (cl/p) risk. |
| PubMedID- 22750566 | We have applied a gwas to 40 consanguineous families segregating cases of non-syndromic cleft lip with or without cleft palate (ns cl/p) (a total of 160 affected and unaffected individuals) in order to trace potential recessive loci that confer susceptibility to this common facial malformation. |
| PubMedID- 22223055 | The arizona birth defects monitoring program (abdmp) is mandated to collect data on several birth defects including oro-facial clefts such as cleft lip with and without cleft palate (cl) and cleft palate without cleft lip (cp). |
| PubMedID- 23166094 | Nonsyndromic cleft lip with or without cleft palate (nscl/p) is one of the most common craniofacial malformation in humans. |