PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | |cleft palate |
| Sentences | 332 |
| PubMedID- 25808365 | Rs1801133c>t polymorphism in mthfr is a risk factor for nonsyndromic cleft lip with or without cleft palate in the brazilian population. |
| PubMedID- 26402724 | Participants: the study sample consisted of 189 case-parent trios of nonsyndromic cleft lip with or without cleft palate (nscl+/-p), 107 case-parent trios of nonsyndromic cleft palate (nscp), 318 isolated samples of nscl+/-p, 189 isolated samples of nscp, and 599 healthy controls. |
| PubMedID- 21132229 | Results: high frequencies regional analysis showed the following significant results: pam: severe hypospadias; cen: spina bifida, microtia, cleft lip with cleft palate, polycystic kidney, postaxial polydactyly and down syndrome; cuy: postaxial polydactyly; noa: omphalocele, gastroschisis, cleft lip without cleft palate, cleft lip with cleft palate, anorectal atresia/stenosis, indeterminate sex, preaxial polydactyly and pectoral agenesis; pat: cleft lip without cleft palate. |
| PubMedID- 26507587 | Interactions between rad51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 20878909 | Stratification by type of surveillance system showed that active programs had a higher prevalence of anencephaly, anophthalmia/microphthalmia, cleft lip with or without cleft palate, reduction defect of upper limbs, and trisomy 18. |
| PubMedID- 25704602 | Identification of functional variants for cleft lip with or without cleft palate in or near pax7, fgfr2, and nog by targeted sequencing of gwas loci. |
| PubMedID- 26110153 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. |
| PubMedID- 22549767 | To demonstrate the application, we apply our method to candidate gene sequencing data from a german case-control study on nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 22363504 | Clptm1 is a candidate gene for cleft lip with or without cleft palate malformation [19], [20]. |
| PubMedID- 22471252 | The aim of this study was to assess the accuracy of prenatal diagnosis of cleft lip with or without cleft palate, and isolated cleft palate (icp), in our catchment area. |
| PubMedID- 22723972 | For haplotype analysis, we used a sliding-window approach and assessed isolated cleft lip with or without cleft palate (icl/p) separately from isolated cleft palate only (icpo). |
| PubMedID- 22345991 | Background: cleft lip with or without cleft palate (cl/p) is the most frequent craniofacial malformation seen in man. |
| PubMedID- 21381882 | Cchd, anencephaly, spina bifida, congenial diaphragmatic hernia (cdh), omphalocele, gastroschisis, limb defects, cleft lip with or without cleft palate (cl/p) and isolated cleft palate were evaluated. |
| PubMedID- 23028347 | In a recent candidate gene study carried out in two independent european population samples, we investigated a potential association between risk alleles for non-syndromic cleft lip with or without cleft palate (nscl/p) and nose width and facial width in the normal population [20]. |
| PubMedID- 21113916 | The distribution of clefts was as follows: 18 (29%) cleft lip, 25 (40%) cleft lip with cleft palate, 17 (27%) cleft palate only, one median cleft and one atypical cleft. |
| PubMedID- 23776525 | Non-syndromic cleft lip with or without cleft palate (nscl/p [omim %119530]) is one of the most common congenital defects. |
| PubMedID- 21760670 | Compared cleft palate patients with cleft lip, alveolus and palate patients, but there was no cleft lip group included. |
| PubMedID- 22090755 | Stevenson and johnson[16] stated that cleft lip with or without cleft palate is more common in males with the ratio of approximately 2:1 over females; our study correlates the above study. |
| PubMedID- 20020508 | Nonsyndromic cleft lip with or without cleft palate (clp) is a frequent craniofacial malformation caused by both genetic and environmental factors. |
| PubMedID- 23903689 | Forms of nsoc include cleft lip with or without cleft palate (cl/p)and cleft palate only (cpo) (2). |
| PubMedID- 21834038 | Moreover, the apparent protection against cleft lip with or without cleft palate (cl/p), cleft lip with cleft palate (clp), and cleft lip only (clo) was also identified in stratified analysis. |
| PubMedID- 26540672 | The aim of the investigation was to replicate previous studies reporting evidence of association between polymorphisms of folate related genes and the occurrence of non-syndromic cleft lip with or without cleft palate (nscl/p), using three independent samples of different ancestry: from tibet, bangladesh and iran, respectively. |
| PubMedID- 21781437 | Maternal c677t mthfr genotype has been identified as important factor in cleft lip with or without cleft palate (cl/p) etiology. |
| PubMedID- 21254359 | Background: nonsyndromic cleft lip with or without cleft palate (nsclp) is a common complex birth defect. |
| PubMedID- 26336015 | The prevalence of cleft lip with or without cleft palate was 0.9 per 10000 children, achondroplasia was 0.7 per 10000, and dandy-walker syndrome was 0.4 per 10000. |
| PubMedID- 24375841 | Objective: to investigate trends in prenatal diagnosis and termination of pregnancy rates in cases of fetal cleft lip with or without cleft palate (cl +/- p), before and after the introduction in the netherlands of the 20-week anomaly scan in 2007, and to assess the accuracy of this scan for the diagnosis of facial clefts. |
| PubMedID- 22415108 | Methods: in a prospective cohort of 240,244 women enrolled between 1993 and 1995 in 1 northern and 2 southern provinces in china, we examined the risk of nonsyndromic cleft lip with or without cleft palate (cl/p) and cleft palate alone (cp) in relation to maternal use of 400 mug of folic acid without other vitamins. |
| PubMedID- 20681225 | There was bilateral cleft lip with cleft palate. |
| PubMedID- 26140186 | cleft lip with or without cleft palate (cl/p) is among the most common orofacial congenital anomalies in the world 1. several epidemiological studies have reported the prevalence of cleft lip and/or palate in iran and worldwide 2–8. |
| PubMedID- 24304547 | Analyses evaluating cleft lip (with or without cleft palate) and cleft palate separately were similar to analyses evaluating both oral cleft defects combined, except the or for cleft palate and average 1st trimester tce exposure > mcl was elevated (cleft palate or = 1.4, 95% ci: 0.3-7.0 versus the combined oral clefts or = 0.8, 95% ci: 0.2-3.0), but this was based on two exposed cases. |
| PubMedID- 22565872 | Although muenke syndrome is the most common syndromic form of craniosynostosis, the frequency of oral and palatal anomalies including high-arched palate, cleft lip with or without cleft palate has not been documented in a patient series of muenke syndrome to date. |
| PubMedID- 25884320 | For non-syndromic cl ± p (cleft lip with or without cleft palate), the recurrence risk for a subsequent sibling is considered to be 3-5% [49,51]. |
| PubMedID- 24454740 | Because of suggested differences in genetic origin [1], [5], [22], we also analysed oral clefts subdivided into cleft lip with or without cleft palate (icd-10 codes q36 and q37) and isolated cleft palate (q35). |
| PubMedID- 22754157 | cleft lip with or without cleft palate occurs in approximately 0.91–2.69 in 1000 white births. |
| PubMedID- 23008150 | Expression and mutation analyses implicate arhgap29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22. |
| PubMedID- 21408183 | However, the importance of cncs in disease has been documented in several disorders including preaxial polydactyly [15], [16], [17], human nscl/p (non syndromic cleft lip with or without cleft palate) [18] holoprosencephaly [19] and pierre robin sequences (a subgroup of cleft palate) [20]. |
| PubMedID- 24531247 | cleft lip with or without cleft palate (cl/p) is a relatively common craniofacial malformation involving bony and soft-tissue disruptions of the nasolabial and dentoalveolar regions. |
| PubMedID- 24706492 | Nonsyndromic cleft lip with or without cleft palate: increased burden of rare variants within gremlin-1, a component of the bone morphogenetic protein 4 pathway. |
| PubMedID- 21612398 | On the contrary, mthfr 1298 ac and 1298 ac/cc appeared to be protective against cleft lip with cleft palate. |
| PubMedID- 20023658 | Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 22759670 | cleft lip with or without cleft palate (clp) and cleft palate only (cp) are severe disruptions affecting orofacial structures. |
| PubMedID- 26043427 | Association between polymorphisms at the grem1 locus and the risk of nonsyndromic cleft lip with or without cleft palate in the polish population. |
| PubMedID- 22754168 | cleft lip (with or without cleft palate) has been seen in nearly all cases of popliteal pterygium syndrome, whereas cleft palate is present in only 41% of multiple pterygium syndrome. |
| PubMedID- 20087401 | Isolated cleft lip with or without cleft palate and cleft palate are among the most common human birth defects. |
| PubMedID- 23055981 | cleft lip, with or without cleft palate, and isolated cleft palate occur with a frequency of 1–2 in thousand live births. |
| PubMedID- 25786657 | Replication of 13q31.1 association in nonsyndromic cleft lip with cleft palate in europeans. |
| PubMedID- 20526256 | Background: the purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip, with or without cleft palate (nscl/p), and to analyze the relationships between the type of nscl/p in the affected individual and his/her parent, looking at children in the first grade. |
| PubMedID- 22875508 | Objective: to explore the association between parental genetic polymorphism of methylenetetrahydrofolate reductase (mthfr) 677c/t and occurrence of nonsyndromic cleft lip with or without cleft palate (nscl/p) in offspring in shandong province. |
| PubMedID- 25885235 | The cleft lip (with or without cleft palate) is more common in males, whereas isolated cleft palate is more common in females. |
| PubMedID- 23395979 | Our findings suggest that the duplicated segment predisposes for cleft lip with or without cleft palate (cl/p), or any of the other phenotypic features presented by the patient. |