PedAM
Pediatric Disease Annotations & Medicines
| Disease | severe combined immunodeficiency |
| Phenotype | |severe combined immunodefic |
| Sentences | 174 |
| PubMedID- 23150174 | Six-week-old severe combined immunodeficient (scid) male mice (n = 30) were injected with hek293 cd133high and cd133low transfectants subcutaneously into the right and left flanks of the same mouse, respectively (5 × 103, 1 × 105, or 5 × 106 cells per injection in 100 μl medium and 100 μl matrigel, bd pharmingen). |
| PubMedID- 22745542 | Thirteen 8-week-old male nonobese diabetic severe combined immunodeficient gamma mice were purchased from jackson laboratory (indianapolis, in) and used to generate the orthotopic model. |
| PubMedID- 22843486 | severe combined immunodeficient (scid) mice (seven per group) were grafted with human synovium and skin on either side of the animal subcutaneously in a dorsal position distal to the shoulder joints. |
| PubMedID- 21637808 | Four to six week old female c3h/he, c57bl/6 and severe combined immunodeficient c57bl/b6.c-prkdcscid (scid) mice were obtained from the jackson laboratory, bar harbor, me, and maintained at uc davis in isolator cages under conventional housing conditions. |
| PubMedID- 23900689 | Immunodeficient non-obese diabetic (nod)/severe combined immunodeficient (scid) (nod/scid) mice (5- to 6-week-old) were purchased from harlan laboratories (harlan laboratories, indianapolis, in, usa). |
| PubMedID- 20298547 | T cells or b cells, transferred from arthritic balb/c mice to severe combined immunodeficient (scid) mice, are detectable by in vivo imaging in the popliteal lymph nodes (lns) but not in the joints of the recipient mice. |
| PubMedID- 24592361 | [91011] these vectors are used for the treatment of a number of diseases such as β-thalassemia, hemophilia, severe combined immunodeficiency (scid), cystic fibrosis, and muscular and neurodegenerative diseases in animal models. |
| PubMedID- 26440411 | Eight-week-old male severe combined immunodeficient (scid) mice were used in all experiments. |
| PubMedID- 23135762 | Because chimeric mice have the characteristic of severe combined immunodeficiency, the viral kinetics in chimeric mice sera during ifn treatment could be contributed by the innate immune response of hcv-infected human hepatocytes. |
| PubMedID- 25283340 | severe combined immunodeficiency (scid) mice were bred and maintained in the animal facility of the department of dermatology (university of debrecen) in accordance with the animal-welfare ordinance. |
| PubMedID- 26046360 | severe combined immunodeficiency (scid) female mice (harlan, indianapolis, in) received orthotopic pancreatic injections of s2-vp10 metastatic pancreatic adenocarcinoma cells expressing luciferase, resulting in pancreatic tumors within 7 days. |
| PubMedID- 24375628 | Six-week-old female nonobese diabetic/severe combined immunodeficient (nod/scid) mice (jackson laboratory, bar harbor, me, usa) were implanted with 2.5 × 106 cells in 50 μl of a 1:1 dilution of matrigel (cb-40230a; bd biosciences, san jose, ca, usa) and dmem medium, in the fourth inguinal mfp. |
| PubMedID- 24076575 | severe combined immunodeficiency due to adenosine-deaminase defect (ada-scid) is usually deadly in childhood because of severe recurrent infections. |
| PubMedID- 23122694 | Characterised traits range from severe combined immunodeficiency syndromes, with specific defects in cellular and humoral immunity, to defects in innate immunity such as impaired tlr signalling (box 1, figure 2). |
| PubMedID- 23100393 | Male cb-17 severe combined immunodeficient (scid) mice (6- to 8-weeks old; harlan laboratories,inc., indianapolis) were housed and monitored in our animal research facility. |
| PubMedID- PMC3552307 | Similarly, severe combined immunodeficient (scid) mice were almost completely protected against murine cytomegalovirus infection by poly (iclc), and poly (iclc) was able to induce ifn and nk cell cytotoxicity in these mice [141]. |
| PubMedID- 26234182 | Reproductive age (8-week-old) female non-obsese diabetic, severe combined immunodeficient, interleukin 2 receptor gamma null (nsg) mice from jackson laboratories were housed in accordance with university of california, los angeles (ucla) division of laboratory animal medicine guidelines. |
| PubMedID- 23152004 | Eight-week-old female immunodeficient nude and cb-17 severe combined immunodeficient (scid) mice (charles river laboratories, wilmington, ma, usa) were maintained in a pathogen-free environment, and all in vivo procedures were approved by the synta pharmaceuticals corp. institutional animal care and use committee in accordance with the guide for care and use of laboratory animals. |
| PubMedID- 25962155 | All animal studies with female severe combined immunodeficient (scid) mice (c.b.-17/icrhsd-prkdcscid lystbg; harlan laboratories) were conducted with approval from, and in accordance with, the mayo clinic institutional animal care and use committee, accredited by the american association of laboratory animal care, which meet or exceed the standards set by the u.s. department of agriculture animal welfare act, public health service policy on humane care and use of animals, and the nih guide on laboratory animal welfare. |
| PubMedID- 24573252 | (1991) who showed that severe combined immunodeficient mice, deficient in dsb repair, were hypersensitive to direct dsb inducing ionising radiation or bleomycin treatment but normally sensitive to mitomycin c and uv light, which cause dna inter- and intra-strand crosslinks [29]. |
| PubMedID- 24216290 | Female severe combined immunodeficient (scid) mice at 4 to 6 weeks of age were used in the orthotopic tumor-xenograft model. |
| PubMedID- 19934002 | Showed that severe combined immunodeficient patients who successfully received a transplant of hla-mismatched hematopoietic stem cells have circulating host-reactive t-cell clones producing high levels of il-10 in the absence of il-4. |
| PubMedID- 23651628 | Specific-pathogen-free, 3 to 5 week old c3h/hen (c3h) and severe combined immunodeficient (scid) c3h/smn.cicrhsd-prkdcscid (c3h-scid) mice were obtained from frederick cancer research center (frederick, md) and harlan sprague dawley, inc. (indianapolis, in), respectively. |
| PubMedID- 24062996 | The use of athymic nude mice and severe combined immunodeficient mice serve to avoid graft rejection but the former mice develop new histological changes not seen in psoriasis while the latter mice continue to manifest rejection of the xenogeneic tissue due to presence of nk cells [35]. |