PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | |cleft palate |
| Sentences | 332 |
| PubMedID- 24613087 | Objective: nonsyndromic cleft lip with or without cleft palate (ns-cl/p) is one of the most common craniofacial malformations determined by the interaction between multiple genes and environmental risk factors. |
| PubMedID- 22405490 | cleft lip with palate and cleft palate alone have sizable effects on hospitalizations during both childhood and late adulthood. |
| PubMedID- 22863734 | We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (nscl/p) using data from the two largest genome-wide association studies published to date. |
| PubMedID- 25798845 | Nonsyndromic orofacial clefts, notably cleft lip (cl) with or without cleft palate (cl/p) and isolated cleft palate (cp), are the most common craniofacial birth defects in humans and represent a substantial personal and societal burden. |
| PubMedID- 21425073 | Of all patients, 40 persons (22.6%) had isolated cp, 45 (25.4%) had cleft lip without cleft palate, and 92 (52%) had cleft lip with cleft palate (cl+p). |
| PubMedID- 25760440 | Data extracted from these studies included:passive smoking definition;study design and setting;sample size, description and base population;prevalence and intensity of maternal passive smoking prior to pregnancy and in the first trimester for cases and controls;the frequency of maternal passive smoking for cleft lip with or without cleft palate (cl/p) and cleft palate (cp). |
| PubMedID- 22346195 | There was micro-ophthalmia and oral cavity showed cleft lip with cleft palate. |
| PubMedID- 24206222 | Our analysis provides evidence that defection of cell cycle may result in the common etiology of oral cancer and cleft palate with cleft lip in the view of high activity of cell proliferation both in cancer cell and embryonic palatal shelf. |
| PubMedID- 20880515 | cleft lip with or without cleft palate, cleft lip only, cleft lip with cleft palate and cleft palate only), interestingly, we found that rs16260 overall genotype frequencies in cleft palate only (cpo) groups were significantly different with those in the controls (p=0.004) and rs16260 aa genotype significantly increased the risk of cpo by 5.90-fold (or=6.90, 95% ci=1.47-32.40), providing the first evidence of cdh1 genetic variation in the etiology of cpo. |
| PubMedID- 22956956 | Observed in approximately 1 in 700 live births, cleft lip (with or without cleft palate) is the most common congenital craniofacial birth defect in humans [1–3]. |
| PubMedID- 20662561 | Nonsyndromic cleft lip with or without cleft palate (nscl/p) has a complex etiology, which involves both genetic and environmental factors. |
| PubMedID- 20635363 | Based on association and sequencing studies, investigators have postulated muscle segment homeobox 1 (msx1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (nsclp). |
| PubMedID- 25257647 | Background: the heritable multifactorial etiology of human nonsyndromic cleft lip with or without cleft palate (cl +/- p) is not understood. |
| PubMedID- 22917484 | Objective: the objective of this study was to evaluate the association between the use of monotherapy topiramate in pregnancy and cleft lip with or without cleft palate (cl/p) in the offspring. |
| PubMedID- 21244519 | Non-syndromic cleft lip with or without cleft palate (nsclp) is a malformation with variable phenotypes, resulting from a mixture of genetic and environmental factors. |
| PubMedID- 26505415 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is a common birth defect. |
| PubMedID- 25059012 | Genetic risk score for nonsyndromic cleft lip with or without cleft palate for a chilean population. |
| PubMedID- 24474681 | Identified birth outcomes were a) oral cleft, including cleft lip with and without cleft palate as well as cleft palate [international classification of diseases, ninth revision, clinical modification (icd-9-cm) code 749.xx] (national center for health statistics 2011); b) ntd, including anencephalus, spina bifida without anecephaly, and encephalocele (icd-9-cm 740.xx, 741.xx, and 742.0); c) chd, including transposition of great vessels, tetralogy of fallot, ventricular septal defect, endocardial cushion defect, pulmonary valve atresia and stenosis, tricuspid valve atresia and stenosis, ebstein’s anomaly, aortic valve stenosis, hypoplastic left heart syndrome, patent ductus arteriosis, coarctation of aorta, and pulmonary artery anomalies (codes 745.xx, 746.xx, 747.xx, excluding 746.9, 747.5); d) preterm birth (< 37 weeks completed gestation); e) term low birth weight (≥ 37 weeks completed gestation and birth weight < 2,500 g); and f) term birth weight as a continuous measure. |
| PubMedID- 21358192 | Genetic causes of nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 20082468 | Our previous results indicated a moderate association between the methylenetetrahydrofolate reductase (mthfr) gene 677c-t variant and an increased risk of non-syndromic cleft lip with or without cleft palate (nscl/p) among the northern but not southern population in china, suggesting possible genetic heterogeneity in the etiology of nscl/p between these two populations. |
| PubMedID- 20499406 | Isolated or associated cleft lip, with or without cleft palate (cl/p), or cleft palate (cp) were diagnosed in 18 chromosomally normal fetuses (an incidence of 2.2 per 1000). |
| PubMedID- 25780529 | Background: the methylenetetrahydrofolate reductase (mthfr) is thought to be involved in the development of nonsyndromic cleft lip with or without cleft palate (nscl/p). |
| PubMedID- 23023602 | Transforming growth factor-beta3 intron 5 polymorphism as a screening marker for non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 20828271 | This rose to 28% when only the cases of cleft lip with or without cleft palate (cl +/- p) were considered. |
| PubMedID- 25171615 | Aim of study: the aim of this study was to investigate the contribution of reported candidate genes: vax1 (rs7078160) and bmp4 (rs762642) to the risk of cleft lip with or without cleft palate in the polish population. |
| PubMedID- 21679965 | A relatively high prevalence of cleft lip, with or without cleft palate, was observed. |
| PubMedID- 21039911 | cleft lip with or without cleft palate, cleft palate, cardiovascular cas, oesophageal atresia/stenosis, hypospadias and multiple cas showed a higher risk in the offspring of pregnant women with epilepsy treated with different antiepileptic drugs, explained mainly by polytherapy. |
| PubMedID- 26198054 | Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a brazilian population with high african ancestry. |
| PubMedID- 20811522 | Objectives: cleft lip with or without cleft palate, is the most common serious congenital anomaly that affects the orofacial regions. |
| PubMedID- 22090774 | [15] also cleft lip, with or without cleft palate, is more common than in tcs and some patients may exhibit congenital heart defects. |
| PubMedID- 24634360 | Nonsyndromic cleft lip with or without cleft palate in arab populations: genetic analysis of 15 risk loci in a novel case-control sample recruited in yemen. |
| PubMedID- 23355017 | Objective: this study aims to evaluate the use of fetal brain magnetic resonance imaging (mri) following an antenatal sonographic diagnosis of isolated cleft lip with or without cleft palate (cl/p). |
| PubMedID- 23961635 | Results: among the 27 male and 27femalepatients, 51.85% had cleft lip with cleft palate. |
| PubMedID- 22781422 | Data from a previous study of the association between mthfr c677t and cleft lip with or without cleft palate (cl/p) was analyzed, in order to investigate the maternal effect, fetal effect and their interaction, using a series of log-linear models. |
| PubMedID- 20826065 | The prevalence of cleft lip with or without cleft palate (cl/p) at birth varied from 3.4-22.9 per 10000 births according to different geography and ethnic groups. |
| PubMedID- 23738843 | Teratogenicity data derived from epidemiologic studies and claims data in women using immediate-release topiramate for approved migraine and epilepsy indications showed an increased risk of cleft lip with or without cleft palate in infants exposed to topiramate during the first trimester of pregnancy [31]. |
| PubMedID- 20078200 | (3) the pattern of expression of the phenotypic features identified to date supports the contention that there are differences in the inheritance of cleft lip with or without cleft palate and isolated cleft palate. |
| PubMedID- 21045959 | On the basis of this data, we conclude that irf6 should be screened when any doubt rises about the normality of the lower lip and also if a non-syndromic cleft lip patient (with or without cleft palate) has a family history suggestive of autosomal dominant inheritance. |
| PubMedID- 22499695 | Candidate pathway based analysis for cleft lip with or without cleft palate. |
| PubMedID- 21044801 | Objective: studies in mice and humans have suggested that sumo1, which codes for the small ubiquitin-related modifier 1 (sumo1), is a promising candidate gene for non-syndromic cleft lip with or without cleft palate (nscl/p). |
| PubMedID- 26080863 | Objective: to explore the association between 10 candidate genes on transforming growth factor-beta (tgfb) signaling pathway and non-syndromic cleft lip with or without cleft palate (nscl/p) among chinese populations, and to study the gene-environment interaction. |
| PubMedID- 23774909 | Objective: to explore the association between 18 candidate genes encoding enzymes on the folate/homocysteine metabolism pathway and non-syndromic cleft lip with or without cleft palate (nscl/p) in chinese populations. |
| PubMedID- 24038802 | Nonsyndromic cleft lip with or without cleft palate (nscl/p), the most common type of orofacial clefting, is one of the most frequent congenital defects. |
| PubMedID- 20196142 | Background: nonsyndromic cleft lip with or without cleft palate is a common birth defect. |
| PubMedID- 21781440 | The approach was a family based association study involving a total of 512 italian patients and their parents, 401 having cleft lip with or without cleft palate (cl/p) and 111 with cleft palate only (cpo). |
| PubMedID- 23226815 | Objective: cleft lip with or without cleft palate is the most common orofacial congenital anomaly among live births. |
| PubMedID- 23167473 | Non-syndromic cleft lip with or without cleft palate (cl/p) is a common birth defect with a complex etiology. |
| PubMedID- 25303326 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is a common disorder with complex etiology. |
| PubMedID- 25300891 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common defects in the human facial structure. |
| PubMedID- 21197815 | Results: the calculated incidence of non-syndromal orofacial clefts was 1.69 per thousand live births, comprising 0.85 for cleft lip with or without cleft palate (cl[p]) and and 0.84 for isolated cleft palate (cp). |