PedAM
Pediatric Disease Annotations & Medicines
| Disease | c syndrome |
| Phenotype | |obesity |
| Sentences | 377 |
| PubMedID- 24071981 | In recent years the literature has shown an increasing interest in paediatric obesity and the onset of diabetes and the metabolic syndrome in adulthood. |
| PubMedID- 24816278 | Hepatic manifestations of the metabolic syndrome (hmms) are associated with obesity, type 2 diabetes/insulin resistance, non-alcoholic fatty liver disease (nafld), and progression to non-alcoholic steatohepatitis (nash) [1]. |
| PubMedID- 26379783 | The objective of this study was to determine whether severe obesity in women with metabolic syndrome leads to functional remodeling of arterial wall and change in the corresponding markers. |
| PubMedID- 21593202 | obesity is the hallmark of the metabolic syndrome and represents a major global health problem that frequently associates with the development of chronic diseases, including type 2 diabetes and cardiovascular disease (1). |
| PubMedID- 20514047 | In this regard the ability of adipose tissue to expand and match the storage needs of energy surplus may be a key determinant of the susceptibility to developing metabolic syndrome associated with obesity (1-4). |
| PubMedID- 22694047 | The prevalence of the metabolic syndrome with attendant morbid obesity continues to increase nationwide. |
| PubMedID- 22723994 | Some hypothesized that sua mediates obesity and other features of metabolic syndrome by reducing endothelial nitric oxide and decreasing insulin-mediated glucose uptake in skeletal muscle [8]. |
| PubMedID- 24205128 | Nafld is a common feature of metabolic syndrome being often associated with obesity, dyslipidemia and diabetes and mostly closely linked to insulin resistance. |
| PubMedID- 26024889 | Several cardiovascular risk factors are known to affect platelet aggregation in healthy individuals including age, sex, obesity, and the presence of metabolic syndrome [6–10]. |
| PubMedID- 25659889 | Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. |
| PubMedID- 26183621 | As pparγ is a significant drug target for metabolic syndrome associated with obesity-induced insulin resistance and hyperglycemia3132, we used the db/db diabetic mouse model and their littermates to determine whether chelerythrine has the ability to improve glucose homeostasis in these mice. |
| PubMedID- 21834955 | The relationship between depression and waist circumference or abdominal obesity as a component of metabolic syndrome has been explored previously in studies examining the associations of metabolic syndrome with mental illness [39-43]. |
| PubMedID- 26063458 | Metabolic syndrome is linked with obesity and is often first identified clinically by elevated bmi and elevated levels of fasting blood glucose that are generally secondary to insulin resistance. |
| PubMedID- 22392186 | In this study, we sought to assess the association between brachial artery fmd, high-sensitive c-reactive protein (hs-crp) and cardiovascular risk factors including obesity in patients with cardiac syndrome x. |
| PubMedID- 25755863 | Methods: total of 94 patients were divided into obesity with metabolic syndrome (ms) (n=30), obesity without ms (n=33), and control (n=31) groups. |
| PubMedID- 21176200 | Results from the multiple regression analysis showed that insulin resistance and obesity were associated with the metabolic syndrome. |
| PubMedID- PMC4055882 | Erα undoubtedly plays a role in the estrogenic reduction in ingestive behavior—as evidenced by the fact that the erα agonist ppt decreases food intake and meal size in ovariectomized rats [45], and erα silencing in the vmn results in obesity associated with metabolic syndrome [46]. |
| PubMedID- 26064924 | Young rats that received the cafeteria diet for 8 weeks developed metabolic syndrome along with obesity, higher hepatic weight, increased plasma levels of glucose, insulin and triglycerides, and insulin resistance [57]. |
| PubMedID- 22937748 | Reported cutoff points for waist circumference and their predictive value for abdominal obesity and risk of metabolic syndrome (mets) in the chinese population [13]. |
| PubMedID- 20835560 | Da-paz-filho et al.13 described a decrease in leptin production by adipose tissue in obesity associated with severe metabolic syndrome, suggesting a state of relative leptin deficiency in obesity that is associated with advanced stages of the syndrome. |
| PubMedID- 24847618 | Background: obesity-induced metabolic syndrome is a multiple risk factor for cardiovascular (cv) risk factors and type 2 diabetes, and ethnic minorities seem to have unfavourable medical risk factors in general more frequently than majority populations. |
| PubMedID- 26092037 | These include obesity and components of metabolic syndrome, with the specific systems affected determined by the type and timing of developmental exposure. |
| PubMedID- 23515973 | The great increase in type 2 diabetes has been due to environmental changes, many of which have resulted in obesity associated with the metabolic syndrome and all of its consequences. |
| PubMedID- 21645344 | It has become clear that obesity and features of the metabolic syndrome, which encompass glucose dysregulation, dyslipidemia and hypertension, are key risk factors for the development and progression of nafld [1]. |
| PubMedID- 25527815 | Background: obesity is the hallmark of the metabolic syndrome representing a major global health problem. |
| PubMedID- 25591987 | Taken together, it is clear that baff unites obesity with metabolic syndrome. |
| PubMedID- 26213922 | Indeed, inheritance-oriented investigations concerning gene-nutrient interactions on energy homeostasis processes and metabolic cell functions are extending to all clinically chronic relevant diseases, such as type 2 diabetes, cardiovascular events, obesity and associated features of metabolic syndrome. |
| PubMedID- 26016481 | Nzo/hlltj is a common laboratory strain used as a model of metabolic syndrome because of its extreme obesity and hyperglycemic phenotype [84]. |
| PubMedID- 23435016 | In mice, a two to three-fold elevation of 11β-hsd1 selectively in adipose tissue phenocopies the metabolic syndrome, with central obesity, insulin resistance, dyslipidaemia and hypertension [115,116] whereas similar transgenic expression of 11β-hsd2 in adipocytes (it is not normally expressed in adipocytes), presumably lowering intra-adipose glucocorticoid action, causes insulin sensitisation in high fat fed mice [117]. |
| PubMedID- 23648313 | obesity is closely associated with the metabolic syndrome (mets) and subsequent low-grade inflammation links to endothelial dysfunction (ed) and cardiovascular disease. |
| PubMedID- 23460844 | The abdominal obesity component of the metabolic syndrome was not adjusted by bmi. |
| PubMedID- 23949560 | This attenuation may arise from causal biological correlations between insulin sensitivity, obesity, and clinical definitions of metabolic syndrome. |
| PubMedID- 25621503 | It is well known that an increase in adipokine production can influence glucose metabolism, insulin sensitivity and inflammation, and this finding could represent a molecular link between obesity and the development of diabetes mellitus, metabolic syndromes and cardiovascular diseases [77]. |
| PubMedID- 23696677 | Some studies have suggested that the metabolic syndrome (including obesity) may be associated with dkd in type 1 diabetes. |
| PubMedID- 24111227 | Ultrasonography-based visceral fat estimation is a promising method to assess central obesity, which is associated with metabolic syndrome. |
| PubMedID- 19863955 | Background: in obese patients, positioning of the bioenterics intragastric balloon (bib) proved beneficial for weight loss, but the effect of the device on ameliorating some components of the metabolic syndrome associated with obesity remains uncertain. |
| PubMedID- 23805900 | Associations of cardiorespiratory fitness, physical activity, and obesity with metabolic syndrome in hong kong chinese midlife women. |
| PubMedID- 24270951 | These transitional nutrition regions are very relevant to this type of research because these areas contain a large number of children with low birth weights who are further exposed to diets containing foods of low cost, high caloric value, and low nutrient quality, which may increase the incidence of obesity and diseases associated with metabolic syndrome (9). |
| PubMedID- 23819808 | Background: it has been well documented that obesity is closely associated with metabolic syndrome (mets). |
| PubMedID- 24396679 | The crucial components that may link abdominal obesity to other features of the metabolic syndrome and end-organ damage are presumably the presence of insulin resistance and elevated insulin levels, increased inflammation with macrophage infiltration in fat tissues with concomitant release of proinflammatory cytokines, and endothelial dysfunction, which all may lead to sht. |
| PubMedID- 22777542 | According to skilton et al.,35 adjusting for bmi, in this case, will produce findings that address the association between macronutrient composition and the non-obesity components of the metabolic syndrome. |
| PubMedID- 25922847 | Thus, the ability of adipose tissue to expand and match the storage needs of energy surplus may be a key determinant in protection against the metabolic syndrome associated with obesity [72]. |
| PubMedID- 23354399 | Cardiometabolic syndrome occurs with obesity and consists of pathophysiological factors that increase the risk for cardiovascular events. |
| PubMedID- 24489111 | High-fat diet is considered to be one of the main stressors that can induce negative effects in animals such as metabolic syndrome with obesity, insulin resistance, and fatty liver. |
| PubMedID- 26110103 | obesity is closely associated with metabolic syndrome, type 2 diabetes mellitus (t2dm) and cardiovascular diseases. |
| PubMedID- 22691241 | Logistic regression (backward selection) was further performed to calculate odds ratios (ors) for high versus low homa-ir according to demographic and lifestyle (gender, age, tobacco use), metabolic (obesity, hypertension, use of statins, metabolic syndrome), and clinical parameters, including the das28, health assessment questionnaire (haq), crp, and ra treatment modality (glucocorticoids, methotrexate). |
| PubMedID- 23930111 | Background: obesity in accordance with metabolic syndrome (mets) confronts populations at the higher risk of morbidity and mortality of chronic diseases including, chronic kidney diseases (ckd). |
| PubMedID- 22396222 | Taken together, these findings indicate that inhibiting adipogenic differentiation of hamscs by artemisinic acid occurs primarily through reduced expression of c/ebp delta, which is mediated by the inhibition of jnk and suggest that aremisinic acid may be used as a complementary treatment option for obesity associated with metabolic syndrome. |
| PubMedID- 22809366 | In addition, fatty liver is a manifestation of metabolic syndrome, and is associated with obesity, type 2 diabetes mellitus (t2dm), and hypertriglyceridemia [11]. |
| PubMedID- 23714599 | Background: opinions differ over the exercise modalities that best limit cardiovascular risk (cvr) resulting from visceral obesity in individuals with metabolic syndrome (mets). |