PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Phenotype | |diabetes |
| Sentences | 529 |
| PubMedID- 24625012 | In addition, diabetes is associated with cardiovascular disease, which is an important contributor to the overall morbidity and mortality associated with this condition. |
| PubMedID- 25179966 | Peripheral neuropathy may be a potential risk of cardiovascular disease in diabetes mellitus. |
| PubMedID- 26221527 | Consistent with the present results, that report suggested that cd34+ cell counts might be a more useful clinical marker of cardiovascular disease progression in patients with diabetes than the number of epcs. |
| PubMedID- 23227510 | [a current model for predicting the risk of cardiovascular diseases in patients with type 2 diabetes mellitus]. |
| PubMedID- 21331374 | Current recommendations for adults state that the added cardiovascular disease risk associated with diabetes is equivalent to that of a previous myocardial infarction. |
| PubMedID- 25885892 | This may be as a direct result of a longer duration of diabetes with more micro-vascular disease and less optimal glycemic status at the start of pregnancy with only 41% having an hba1c <7% in trimester 1. micro-vascular disease has been demonstrated to compromise placental circulation and to increase risk of stillbirth and preeclampsia [9,13]. |
| PubMedID- 19875998 | The impact of obesity on cardiovascular disease (cvd) outcomes in patients with type 2 diabetes mellitus (t2dm) and established coronary artery disease (cad) is controversial; whether bmi and/or waist circumference correlate with atherothrombotic risk factors in such patients is uncertain. |
| PubMedID- 26078978 | The presence of macrovascular disease in patients with type 2 diabetes may be a confounding factor when assessing an association of vitamin d with other conditions. |
| PubMedID- 19398138 | To assess the role of diabetes in vascular disease we investigated the number and viability of circulating epcs and related this to endothelial function. |
| PubMedID- 23856609 | However, vegf therapy is not very effective in models of cardiovascular diseases associated with diabetes, and the mechanisms of this phenomenon still remain to be elucidated. |
| PubMedID- 23466101 | To determine the mechanism through which adiponectin deficiency mediates accelerated cardiovascular disease in patients with diabetes, we investigated the effects of adiponectin on macrophage cholesterol deposition. |
| PubMedID- 20020220 | Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study. |
| PubMedID- 20959955 | Non-fasting lipids and risk of cardiovascular disease in patients with diabetes mellitus. |
| PubMedID- 23031547 | The risk factors for ischemic stroke include aging, hypertension, diabetes, smoking, history of cardiovascular diseases (cvd), atrial fibrillation, and left ventricular hypertrophy[5,6]. |
| PubMedID- 23160724 | The risk of death from cardiovascular disease among people with diabetes who reported a moderate to high physical activity level was similar to inactive people without diabetes. |
| PubMedID- 23961478 | For high-risk patients, ldl-c treatment goal was ldl <100 mg/dl but an ldl-c goal of <70 mg/dl was considered a therapeutic option for very high risk patients who had recent heart attacks, cardiovascular disease with diabetes, metabolic syndrome, or severe/poorly controlled risk factors. |
| PubMedID- 24567354 | Increased white blood cell (wbc) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (nlr) is associated with metabolic syndrome. |
| PubMedID- 25019007 | Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the collaborative atorvastatin diabetes study (cards). |
| PubMedID- 26248341 | Overall, rage activation in vsmc could represent a keystone in the development of vascular diseases associated with diabetes by interfering with the contractile phenotype of vsmc through the modification of their mechanical and functional properties. |
| PubMedID- 25393017 | Advanced glycation end products (ages) are thought to contribute to the abnormal lipoprotein profiles and increased risk of cardiovascular disease in patients with diabetes and renal failure. |
| PubMedID- 25325279 | Many studies have reported postprandial hyperglycemia as a major cause of adverse cardiovascular disease in patients with diabetes mellitus [23]. |
| PubMedID- 25849783 | Background: both non-alcoholic fatty liver disease (nafld) and type 2 diabetes increase the risk of developing cardiovascular disease. |
| PubMedID- 24357694 | A novel and potentially translational finding of this investigation is the notion that the type of glucose biomarker measurement has some intrinsic relationship to metabolic memory in understanding the natural micro- and macrovascular disease progression in patients with type 1 diabetes (fig. |
| PubMedID- 24199160 | In the phase ii effect of the dual peroxisome proliferator-activated receptor-α/γagonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (synchrony) study, aleglitazar showed dose-dependent metabolic benefits, including significant dose-dependent reduction in hba1c of -0.36% (4 mmol/mol, 50 µg; p=0.048) to -1.35% (15 mmol/mol, 600 µg; p<0.0001) in 16 weeks of treatment compared to placebo. |
| PubMedID- 23029252 | Established risk predictors include age, sex, diabetes, smoking, family history of cardiovascular disease, baseline levels of nt-probnp, ck-mb, and tnt. |
| PubMedID- 26097512 | Obesity itself has been shown to predispose an individual to hypertension and cardiovascular disease [9], with diabetes predisposing to complications such as neuropathy, diabetic nephropathy, peripheral vascular disease and retinopathy [10]. |
| PubMedID- 20040043 | [37] to suggest that rosiglitazone may contribute to a decrease in the development of vascular diseases associated with type 2 diabetes mellitus through actions on pecam-1. |
| PubMedID- 20798334 | Objective: cerebral microvascular disease associated with type 2 diabetes may exacerbate the effects of aging on cognitive function. |
| PubMedID- 23922510 | Epidemiological analysis and randomized clinical trials have shown the impact of high blood pressure as risk factors for microvascular and macrovascular disease in patients with diabetes (29). |
| PubMedID- 23887188 | A similar model indicated that in the past five years; aging, diabetes duration and presence of cardiovascular disease were inversely related factors to having been vaccinated for pneumococcal disease. |
| PubMedID- 22827862 | These figures are reflected in important obesity-related complications, such as hypertension, hyperlipidemia, and type 2 diabetes, all leading causes of cardiovascular disease.2 type 2 diabetes affects 8.3% of the u.s. population (27% of u.s. residents aged 65 years and older), whereas 35% of u.s. adults have fasting glucose and glycosylated hemoglobin (hba1c) levels in the prediabetic range.3 thus, it is of great importance to characterize contributing etiological factors in order to effectively counteract the obesity and diabetes epidemics. |
| PubMedID- 25849735 | Moderately increased albuminuria, which was formerly called microalbuminuria and has been described as an early diagnostic marker of diabetic nephropathy [1], is now widely accepted as an independent predictor of cardiovascular disease in patients with diabetes [2], hypertension [3,4], and even in the general population [5–8]. |
| PubMedID- 20415560 | Vitamin e reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. |
| PubMedID- 25191571 | Dietary strategies for alleviating health complications, such as premature vascular disease,associated with type 2 diabetes (t2d) and obesity are actively being pursued as alternativesto pharmaceutical interventions(1). |
| PubMedID- 20185811 | The present study includes 740 men and 777 women with diabetes who were free of cancer and cardiovascular disease at blood draw, and who had detectable lp-pla2 activity values. |
| PubMedID- 25878764 | It is also associated with severe complications; for example, diabetes doubles the risk of developing cardiovascular diseases (cvd) that currently constitute the leading cause of mortality in developed countries [2]. |
| PubMedID- 26056618 | Accordingly, we constructed a predictive model for the appearance of cardiovascular diseases in patients with type 2 diabetes admitted via the emergency department. |
| PubMedID- PMC4484638 | Even though the exact mechanism for accelerated vascular disease in diabetes is not yet fully clear, existing research has defined numerous risk factors involved in diabetes, such as oxidative stress [5, 6], dyslipidemia [4, 5], advanced glycation [7], decline in nitric oxide production, activation of the renin-angiotensin aldosterone system, and endothelial inflammation [4]. |
| PubMedID- 25883983 | There are numerous cardiovascular diseases that occur in patients with diabetes, both type 1 or type 2. dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. |
| PubMedID- 21525477 | Minor reductions in egfr are linked to increased risk for renal and cardiovascular disease in patients with diabetes as well. |
| PubMedID- 24843460 | In contrast, the accord study showed that type 2 diabetes subjects (with cardiovascular disease or at least two risk factors for cardiovascular disease or severe atherosclerosis) who underwent intensive glycemic control (target hba1c < 6.0%) showed rather increased mortality (hazard ratio 1.22) compared with those who received standard glycemic control (target hba1c 7.0–7.9%), and thus warned of the unexpected risk of strict glycemic control7. |
| PubMedID- 23442498 | Advanced glycation end products (ages), final products of the non-enzymatic reaction between reducing sugars and amino groups in proteins, lipids and nucleic acids, promotes inflammation to accelerate the progression of vascular disease in patients with diabetes as well as other mechanisms [1]. |
| PubMedID- 24678413 | The exclusion criteria were subjects who had diabetes mellitus, history of cardiovascular disease and heart failure, presence of cerebrovascular disease, arrhythmias (atrial fibrillation), history of ophthalmic surgery, cataract which affects the corrected visual acuity, glaucoma, and vitreous and retinal diseases. |
| PubMedID- 25526505 | Although the role of glycemic control on microvascular disease in patients with type 2 diabetes was documented in the united kingdom prospective diabetes study24 and other recent studies,4,7 the role of glycemic control for reducing mortality has not yet been established for patients with type 2 diabetes.5–7 although most clinicians agree that effective glycemic control is a desirable intervention for patients with diabetes, the association with increased incidences of hypoglycemia demonstrated in accord, advance and vadt trails has limited the treatment. |
| PubMedID- 21655762 | Concomitant with the clinical improvement in cp, a reduction was observed in the serum levels of il-6 and us-crp, both of which are markers of the systemic inflammatory response, in agreement with the results of other publications.10,13,20,21 considering that chronic inflammation is a risk factor for atherosclerotic cardiovascular disease in patients with hypertension and diabetes mellitus, the main causes of ckd, it is plausible that the immediate diagnosis of cp followed by pt should constitute an important preventive measure in the course of ckd in the everyday clinic. |
| PubMedID- 26078757 | Opg is associated with poor glycaemic control and cardiovascular disease (cvd) in patients with type 1 diabetes, compatible with the hypothesis that opg is associated with the development of diabetic vascular complications [31]. |
| PubMedID- 21709299 | On the basis of our pooled analysis, we suggest prospective controlled studies are needed to test more aggressive therapeutic targets for pp glycemia in pregnancies affected by diabetes, uncomplicated by underlying vascular disease, hypertension, or smoking, and controlled for bmi and gestational age. |
| PubMedID- 24379835 | Current evidence indicates that low vegetable consumption is associated with obesity, diabetes and higher risk of cardiovascular diseases and increased rate of some cancers. |
| PubMedID- 25899686 | Cirrhosis) is higher than that for cardiovascular disease among patients with diabetes [1,2]. |
| PubMedID- 26003174 | The pathophysiology of vascular disease in diabetes involves abnormalities in endothelial and vsmcs, and alterations in platelet function [14,15]. |