PedAM
Pediatric Disease Annotations & Medicines
| Disease | schizophrenia |
| Phenotype | |cognitive deficits |
| Sentences | 145 |
| PubMedID- 25142099 | Objective: cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (ache). |
| PubMedID- 20544314 | Thus, modeling cognitive deficits associated with schizophrenia in animals is generally believed to be a very useful strategy, and substantial effort is being expended to refine existing animal tests and develop novel ones that have validity for domains of cognitive performance identified by matrics [21, 22]. |
| PubMedID- 24919170 | cognitive deficits in schizophrenia are important predictors of impairment in most functional domains and are a critical therapeutic target. |
| PubMedID- 21629446 | Positive allosteric modulators (pams) of mglur5 receptor function were originally designed to indirectly increase nmda receptor function, and therefore possibly alleviate some of the cognitive deficits associated with schizophrenia in accordance with the nmda receptor hypofunction model of this disorder [105-107, 149-151]. |
| PubMedID- 25827398 | Alpha7 nicotinic acetylcholine receptors (nachrs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associated with schizophrenia and alzheimer's disease (ad). |
| PubMedID- 22659472 | The cognitive deficits associated with schizophrenia are recognized as a core component of the disorder, yet there remain no available therapeutics to treat these symptoms of the disease. |
| PubMedID- 25109501 | Purpose: cognitive deficits in schizophrenia mainly affect memory, attention and executive functions. |
| PubMedID- 25773225 | Fourthly, neurological side effects of antipsychotic drugs and their treatment are reviewed; and lastly, we discuss neurocognitive deficits in patients with schizophrenia and their treatment. |
| PubMedID- 21084390 | The alpha(7) nicotinic acetylcholine receptor (nachr) is a potential therapeutic target for the treatment of cognitive deficits associated with schizophrenia, alzheimer's disease, parkinson's disease, and attention-deficit/hyperactivity disorder. |
| PubMedID- 25139002 | Conclusion: altogether, these findings point to deficits in a specific thalamo-cortical circuitry in schizophrenia, which is associated with some cognitive deficits commonly reported in those patients. |
| PubMedID- 21779401 | A behavioural procedure to potentially model cognitive deficits associated with schizophrenia concerns the use of mk-801 during extinction of a learned response. |
| PubMedID- 20571978 | Its activity against the cognitive deficits associated with schizophrenia has to be carefully investigated. |
| PubMedID- 23847468 | cognitive deficits in individuals with schizophrenia (scz) are considered core symptoms of this disorder, and can manifest at the prodromal stage. |
| PubMedID- 22708598 | Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions. |
| PubMedID- 20661811 | cognitive deficits in patients with schizophrenia constitute a limiting factor to the chances of rehabilitation of daily living abilities, like personal and relational autonomy and working ability. |
| PubMedID- 24345263 | Much of this literature has focused on animal models of neuropathology and cognitive deficits associated with schizophrenia and other human conditions. |
| PubMedID- 23346419 | Npas, a bhlh transcription factor that is broadly expressed in the developing neuroepithelium, was identified as a risk factor for schizophrenia and associated with cognitive deficits in an affected mother and her daughter [89, 90]. |
| PubMedID- 20701825 | Classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (da) function. |
| PubMedID- 20889653 | Objective: certain cognitive deficits in individuals with schizophrenia have been linked to disturbed gamma-aminobutyric acid (gaba) and glutamate neurotrans-mission in the prefrontal cortex. |
| PubMedID- 25552433 | Although a link between prefrontal gaba hypofunction and cognitive deficits associated with schizophrenia has been proposed, until recently there has been surprisingly little preclinical research investigating the contribution of the gaba transmission to cognitive functions governed by the frontal lobes. |
| PubMedID- 23818944 | Deficits in executive function and sustained attention are two well-studied neurocognitive deficits in patients with schizophrenia, which are robustly linked to the genetic predisposition for schizophrenia [24]. |
| PubMedID- 19732482 | Background: cognitive deficits in schizophrenia are well established and are known to be present during the first episode of a psychotic disorder. |
| PubMedID- 26089815 | Oxt is likely to also contribute to the cognitive deficits associated with schizophrenia, such as impaired spatial memory and cognitive flexibility (3, 174). |
| PubMedID- 23161113 | cognitive deficits are prevalent in patients with schizophrenia (scz) and worsen with old age. |
| PubMedID- 24782733 | Although the underlying mechanisms require further investigation, our data suggest that valproate has great potential for improving cognitive deficits in patients with schizophrenia, especially males with nrg1 haploinsufficiency. |
| PubMedID- 22982201 | Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at mir-137. |
| PubMedID- 19665142 | Neurocognitive deficits in schizophrenia are associated with alterations in blood levels of neurosteroids: a multiple regression analysis of findings from a double-blind, randomized, placebo-controlled, crossover trial with dhea. |
| PubMedID- 20846272 | Conclusion: cognitive deficits in schizophrenia might be driven by abnormal fronto-posterior communication. |
| PubMedID- 21669462 | schizophrenia is associated with many neurocognitive deficits, some of which are improved by nicotine and cigarette smoking. |
| PubMedID- 22038534 | The efficacy but not the motoric side effects of antipsychotics was enhanced, suggesting that adjunctive therapy of alpha7 nachr agonists not only could be useful for the treatment of cognitive deficits associated with schizophrenia but also could enhance the efficacy against positive symptoms. |
| PubMedID- 22053182 | cognitive deficits of patients with schizophrenia have been largely recognized as core symptoms of the disorder. |
| PubMedID- 22405729 | Background: the heterogeneity of symptoms and cognitive deficits in schizophrenia can be explained by abnormal connectivity between brain regions. |
| PubMedID- 23847557 | An impressive number of studies have actually shown that the development of schizophrenia may be associated with these cognitive deficits and that these cognitive deficits could be stage-specific (heaton et al., 1994; niendam et al., 2006; fusar-poli et al., 2007; lysaker et al., 2007; langdon and ward, 2008; picard et al., 2009; barlati et al., 2012). |
| PubMedID- 23308105 | Our study replicates the findings of numerous studies that demonstrated the presence of neurocognitive deficits in patients with schizophrenia on most domains tested, including attention, vigilance, and immediate memory, working memory, delayed memory and executive function [1]. |
| PubMedID- 22654380 | This also holds true for mirtazapine which, in addition, showed favorable effects on cognitive deficits usually associated with schizophrenia in several rcts (stenberg et al., 2011[27]). |
| PubMedID- 20050718 | Conclusions: the rbans highlighted the cognitive deficits in schizophrenia and bd patients compared to controls and also each other. |
| PubMedID- 22408449 | It is a compound found in pacific nemertine paranemertes peregrina and currently tested for treatment of alzheimer’s disease and cognitive deficits associated with schizophrenia [107]. |
| PubMedID- 22666197 | Recent research suggests that the cerebral correlates of cognitive deficits in schizophrenia are nested in the activity of widespread, inter-regional networks rather than being restricted to any specific brain location. |
| PubMedID- 25553979 | Conclusions: aberrant theta-band connectivity may represent a trait characteristic of schizophrenia associated with neurocognitive deficits. |
| PubMedID- 22701481 | schizophrenia is associated with cognitive deficits [141]. |
| PubMedID- 19945256 | Efforts to identify differential or core cognitive deficits in schizophrenia have been made for several decades, with limited success. |
| PubMedID- 23330829 | Not surprisingly, such drugs have been utilized to treat cognitive deficits in patients with schizophrenia in a handful of clinical trials. |
| PubMedID- 24391602 | Furthermore, chronic cannabis use has been associated with gray matter volume changes and cognitive deficits reminiscent of those in schizophrenia (144–147). |
| PubMedID- 24050963 | The importance of cognitive deficits in schizophrenia is emphasized by reports indicating that the severity of cognitive deficits is predictive of treatment compliance, adherence, and risk of relapse among first-episode individuals. |
| PubMedID- 21632647 | Objective: cognitive deficits in schizophrenia are associated with altered activity of the dorsolateral prefrontal cortex, which has been attributed to lower expression of the 67 kda isoform of glutamic acid decarboxylase (gad67), the major gamma-aminobutyric acid (gaba)-synthesizing enzyme. |
| PubMedID- 23778581 | Impairment of the gamma-aminobutyric acid (gaba) signaling system is believed to partially account for behavioral and cognitive deficits associated with schizophrenia and mood disorders.1, 2 reduction of gabaa mediated signal transmission has also been associated with anxiety, panic, impaired learning and memory.3, 4, 5 gabaa receptors are responsible for mediating the fast inhibitory action of gaba,6 and are important sites for clinical action of a number of drugs including benzodiazepines, barbiturates and anesthetics. |
| PubMedID- 23785309 | To date, however, there has been limited success in clinical trials of treatments aiming to reverse cognitive deficits in patients with schizophrenia (javitt et al., 2012; keefe et al., 2013). |
| PubMedID- 20048021 | Objective: premorbid cognitive deficits in schizophrenia are well documented and have been interpreted as supporting a neurodevelopmental etiological model. |
| PubMedID- 22407730 | Trait-related cognitive deficits in schizophrenia and bipolar disorder may share major phenotypic similarity in later life. |
| PubMedID- 23630632 | In addition, negative symptoms such as social withdrawal are related to cognitive deficits in patients with schizophrenia [49]. |