PedAM
Pediatric Disease Annotations & Medicines
| Disease | proteinuria |
| Phenotype | |hypertension |
| Sentences | 94 |
| PubMedID- 25242974 | The term preeclampsia describes the development of hypertension ≥140/90 mmhg with proteinuria ≥300mg/24h after 20th week of gestation (1). |
| PubMedID- 21629798 | proteinuria may occur with or without hypertension (any grade, 4%–36%) and should be monitored during treatment. |
| PubMedID- 20962438 | There was no significant difference in the glomerular filtration rate (gfr) between patients with and without hypertension, whereas gfr in patients with proteinuria was significantly lower than in those without proteinuria (p<0.05). |
| PubMedID- 24753937 | Preeclampsia, defined as pregnancy-induced hypertension with de novo proteinuria, is a serious pregnancy disorder affecting 7 to 10% of all pregnancies together with a high morbidity and mortality for both mother and child (sibai and stella, 2009; reece, 2010). |
| PubMedID- 23002161 | In analogy with hypertension, the higher prevalence of microalbuminuria and proteinuria was found within subjects who were male, older than 60 years, or who had a history of dm or cvd. |
| PubMedID- 24060899 | Preeclampsia, new onset hypertension with proteinuria during pregnancy, is associated with chronic inflammation and placental oxidative stress (ros). |
| PubMedID- 25298602 | The presence of proteinuria in association with hypertension is known to increase the risk of intrauterine growth restriction and prematurity, probably this could be one of the reasons for the low birth weight in the preeclamptic patients. |
| PubMedID- 21802215 | Preeclampsia is a disorder of pregnancy characterized by hypertension with proteinuria after twenty weeks gestation. |
| PubMedID- 24260037 | When hypertension is associated with proteinuria, it can progress to end-stage renal disease (esrd) and requires aggressive treatment [71]. |
| PubMedID- 23226061 | 2-me inhibits hif-1α by possibly destabilizing microtubules in trophoblasts.64 during pregnancy the concentration of maternal circulatory 2-me immediately increases and peaks at term.64,65 the plasma concentration of 2-me is decreased in pre-eclampsia.64 comt-deficient mice (comt−/−) display a pre-eclampsia-like phenotype, including pregnancy-induced hypertension with proteinuria.64 administration of exogenous 2-me ameliorates the hypertension, proteinuria, placental defects, acute atherosis, and glomerular and placental endothelial damage present in pregnant comt−/− mice. |
| PubMedID- 25679511 | A diagnosis of preeclampsia was defined as two or more episodes of hypertension (>140/90 mmhg) with proteinuria after the 20th week of pregnancy. |
| PubMedID- 22498426 | Background: preeclampsia (pe), new-onset hypertension with proteinuria during pregnancy, is associated with increased reactive oxygen species, the vasoactive peptide endothelin-1 (et-1), t and b lymphocytes, soluble antiangiogenic factors sflt-1 and sendoglin (sflt-1 and seng), and agonistic autoantibodies to the angiotensin ii type i receptor (at1-aa). |
| PubMedID- 23308096 | Of interest, pregnancy hypertension, including hypertension with and without proteinuria (preeclampsia), was associated with increased risk among all children diagnosed with an id, but was protective in children with asd only. |
| PubMedID- 24283180 | In this study, pre-eclampsia, proteinuria, and edema associated with hypertension in pregnancy were assessed at the dicle university school of medicine department of obstetrics and gynecology clinic. |
| PubMedID- 23429288 | Pe is defined by the occurrence of gestational hypertension associated with proteinuria after 20 weeks of gestation in a previously normotensive woman.30 impaired trophoblast invasiveness/migration, which results in poor spiral arterial remodeling and consequently inadequate placental perfusion, is believed to cause pe.31, 32 in this study, we found that the level of cul1 is relatively lower in the placentas from pe patients as compared with their matched controls (figure 7; supplementary figure s3, which may suggest that cul1 is disrupted under pathological condition. |
| PubMedID- 25628568 | The disease is clinically manifested and defined as de novo hypertension with proteinuria after 20 gestational weeks (redman, 2011). |
| PubMedID- 26347650 | The classical definition of pre-eclampsia is new-onset hypertension during gestation with proteinuria; however, newer guidelines from the american congress of obstetricians and gynecologists suggest criteria of hypertension coupled with either proteinuria or a broader array of symptoms (thrombocytopenia, renal insufficiency, impaired liver function, pulmonary edema, or cerebral and visual symptoms) could increase the diagnosis of this disorder in the population (american college of obstetricians and gynecologists and task force on hypertension in pregnancy, 2013). |
| PubMedID- 21331165 | It is generally defined as new onset hypertension with proteinuria during pregnancy, although the term is also used to describe worsening blood pressure and proteinuria in women with a history of chronic prepregnancy hypertension [5]. |
| PubMedID- 22934185 | These guidelines defined preeclampsia as new onset hypertension with proteinuria in women who are beyond 20 weeks of gestation. |
| PubMedID- 24733364 | In the nchs multiple birth database, it is impossible to distinguish between gestational hypertension (without proteinuria) and preeclampsia (gestational hypertension with proteinuria). |
| PubMedID- 20426852 | hypertension with proteinuria (pre-eclampsia) was significantly increased in the preterm group. |
| PubMedID- 21789387 | The data collected included patient demographics, antenatal corticosteroid use (two 12 mg intramuscular injections of betamethasone given 24 hours apart), pre-eclampsia (development of new-onset hypertension with proteinuria after 20 weeks gestation), chorioamnionitis (defined as the presence of fever with one or more of the following: maternal leukocytosis >15.000/mm3, uterine tenderness, fetal tachycardia, and foul-smelling amniotic fluid)18, surfactant therapy, survival without bpd at 36 weeks gestational age (as determined by the last menstrual period),19,20 the presence of an air leak (pneumothorax, pneumomediastinum, or pulmonary interstitial emphysema), a papile' grade 3 or above intraventricular hemorrhage (ivh), necrotizing enterocolitis (nec) requiring surgery, a patent ductus arteriosus (pda) requiring surgical closure, stage 3 or greater retinopathy of prematurity (rop) (using the international classification of rop) and mortality. |
| PubMedID- 23418441 | Preeclampsia was defined as gestational hypertension (≥140/90 mmhg) with proteinuria (≥500 mg in a 24-hour period) after the 20th gestational week. |
| PubMedID- 21858206 | Preeclampsia was defined as new-onset hypertension (>140×90 mmhg) associated with proteinuria >0.3 g/24 h. in addition, all patients in this study had early-onset preeclampsia (<34 gestational weeks) and proteinuria was higher than 1 g/24 h in all cases. |
| PubMedID- 26394310 | Preeclampsia usually develops after 20 weeks of gestation and is characterized by chronic or gestational hypertension combined with proteinuria [3], which results from defective placentation eliciting inadequate uteroplacental blood perfusion and ischemia [4, 5]. |
| PubMedID- 25879207 | The associations were similar in the sensitivity analyses (with uacr or upcr within a year as the outcome of interest) except that female gender and hypertension were independently associated with timely proteinuria testing.figure 3proportion of people with uacr and upcr testing within a year by year of joining the cohort.table 3cox regression analysis of uacr testing within 12 months (2229 events of total n = 12,988)variablecategoryunivariatemultivariable*hr(95%ci)phr(95%ci)psex (female vs. male)1.42(1.31-1.54)<0.0011.09(1.00-1.19)0.438age (continuous)0.99(0.98-0.99)<0.0010.99(0.99-1.00)0.028imd quintile (vs. least deprived)1 (most deprived)1.20(1.03-1.40)<0.0010.88(0.75-1.02)0.13521.29(1.13-1.46)1.05(0.92-1.19)31.13(1.01-1.27)0.98(0.87-1.10)40.97(0,86-1.09)0.91(0.81-1.02)cardiovascular disease at baseline (vs. no cvd)1.27(1.16-1.39)<0.0010.948(0.86-1.04)0.260diabetes at baseline(vs. n diabetes)10.24(9.41-11.14)<0.0019.32(8.54-10.18)<0.001hypertension at baseline (vs. no hypertension)1.46(1.34-1.59)<0.0011.06(0.97-1.16)0.215baseline egfr (continuous)1.01(1.01-1.02)<0.0011.01(1.00-1.01)0.014year of joining cohort (vs. 2007)20081.08(0.75-1.56)<0.0011.24(0.86-1.79)<0.00120092.09(1.46-2.99)2.56(1.78-3.68)20102.30(1.60-3.30)2.65(1.84-3.82)20112.34(1.63-3.38)2.73(1.89-3.94)20122.65(1.83-3.83)2.54(1.75-3.69)ckd registration within a year (vs. not)2.94(2.69, 3.22)<0.0012.79(2.55-3.06)<0.001*adjusted for age, sex, index of multiple deprivation, cardiovascular disease, hypertension, diabetes, baseline egfr, year of joining cohort, ckd registration within 1 year.abbreviations in table 3: ckd chronic kidney disease, imd index of multiple deprivation, bp blood pressure, egfr estimated glomerular filtration rate, cvd cardiovascular disease. |
| PubMedID- 24632840 | Nevertheless, the risk for developing hypertension also exceeds that of developing proteinuria in patients treated with different doses of the vegf-antibody bevacizumab. |
| PubMedID- 22838249 | During expectant management 6 patients displayed hypertension with proteinuria, representing preeclampsia, by the 2nd trimester (11-24 weeks) and the other 9 did not (nonpreeclamptic). |
| PubMedID- 26030414 | Hypertensive disorders of pregnancy (hdp) is a pregnancy-specific syndrome defined clinically as hypertension with or without proteinuria after 20 weeks gestation [1]. |
| PubMedID- 25351721 | Pe is pregnancy-induced hypertension in association with proteinuria (>0.3 g in 24 h) with or without oedema (royal college of obstetricians and gynaecologists, 2006). |
| PubMedID- 22728575 | Pre-eclampsia is defined as new onset hypertension with proteinuria during pregnancy. |
| PubMedID- 25955715 | The disease is characterized by de novo hypertension with proteinuria manifesting after 20 gestational weeks [3]. |
| PubMedID- 23976997 | Preeclampsia was defined as gestational hypertension with proteinuria (the presence of blood pressure values ≥140/90 mm hg on 2 measurements at least 6 hours apart; 24 hour urinary protein ≥300 mg or urine dipstick protein≥+) after the 20th week of pregnancy in a previously normotensive and non-proteinuric woman [14]. |
| PubMedID- 23780717 | Here we report a case of a 16-year-old chinese male who was found to have severe hypertension with proteinuria for 2 years. |
| PubMedID- 26539418 | In case group, there was no history of type 1 diabetes, proteinuria with other reasons, hypertension more than 140/90, dialysis, transplantation, arf (acute renal failure), malnutrition and use of supplementary such as zn or other evaluated elements in mineral or purified water. |
| PubMedID- 25531716 | The risk of grade 3/4 thrombocytopenia, hypertension, bleeding, proteinuria, rash, diarrhea, fatigue, headache, anorexia, and febrile neutropenia was significantly increased in the antiangiogenic agent combination groups as compared with the chemotherapy groups. |
| PubMedID- 22995171 | By contrast, chronic infusion of aldosterone induces hypertension with massive proteinuria and glomerular podocyte injury in uninephrectomized (surgical excision of one kidney) rats[69]. |
| PubMedID- 26132137 | Impaired fmd was also associated with proteinuria in patients with diabetes or hypertension [8,9]. |
| PubMedID- 26379126 | Preeclampsia is defined as pre-existing or gestational hypertension concurring with significant proteinuria (>300 mg protein in 24 hour urine sample). |
| PubMedID- 24347821 | Preeclampsia usually develops after 20 weeks of gestation and is characterized by chronic or gestational hypertension combined with proteinuria, which results from defective placentation eliciting inadequate uteroplacental blood perfusion and ischemia [8, 11, 12]. |
| PubMedID- 24156559 | The adulthood version consists of persisting proteinuria with or without hypertension, and a slowly progressing renal impairment. |
| PubMedID- 21099607 | Primary outcomes were the incidence of preeclampsia or gestational hypertension (with and without proteinuria) in the third trimester. |
| PubMedID- 19876819 | Placentas from pregnancies complicated by hypertension without proteinuria had a reduced surface area, with short lesser and maximal diameters. |
| PubMedID- 22738421 | Chronic nephritis syndrome was defined as proteinuria or hematuria with hypertension or edema. |
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