PedAM
Pediatric Disease Annotations & Medicines
| Disease | multiple sclerosis |
| Phenotype | |encephalomyelitis |
| Sentences | 56 |
| PubMedID- 26384335 | Lif and cntf play a protective role in oligodendrocyte survival in vitro [48] and in vivo [49]; furthermore, in an experimental autoimmune encephalomyelitis (eae) animal model of multiple sclerosis (ms), double deletion of lif-r and gp130 to inhibit stat3 activation worsened ms-induced demyelination when compared to wild-type animals [50]. |
| PubMedID- 25881126 | In rats, experimental autoimmune encephalomyelitis (a model of multiple sclerosis) causes an increase in t cells outside leptomeningeal blood vessels in the exposed spinal cord [21], and injection of adjuvant causes an increase in w3/25+ helper t cells in the leptomeningeal layers that adhere to the cortical parenchyma [72]. |
| PubMedID- 22961543 | Persistent nav1.6 activity can trigger axonal injury within white matter axons during experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (craner et al., 2004). |
| PubMedID- 24422881 | Eae: experimental autoimmune encephalomyelitis (mouse model of multiple sclerosis); fcg: four core genotypes; mnr: maternal nutrient restriction; ms: multiple sclerosis; pev: position-effect variegation; ra: rheumatoid arthritis; sle: systemic lupus erythematosus; ssc: systemic sclerosis; xi: inactive x chromosome. |
| PubMedID- 25873897 | H4r-deficient mice or mice treated with an h4r antagonist had significantly worse disease in mouse experimental autoimmune encephalomyelitis models of multiple sclerosis (del rio et al., 2012; ballerini et al., 2013). |
| PubMedID- 23193190 | Moreover, this same study demonstrated that ptpn22 ko mice are less susceptible to the experimental autoimmune encephalomyelitis (eae) model of multiple sclerosis (15). |
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