PedAM
Pediatric Disease Annotations & Medicines
| Disease | maturity-onset diabetes of the young |
| Phenotype | |maturity-onset diabetes |
| Sentences | 137 |
| PubMedID- 20886378 | This new knowledge means that patients who were previously categorized clinically as having maturity-onset diabetes of the young (mody), permanent neonatal diabetes mellitus, or transient neonatal diabetes mellitus can now usually be classified by genetic subgroup. |
| PubMedID- 22162806 | Moreover, rare cel gene defects in this region are responsible for a monogenically derived diabetes condition called maturity-onset diabetes of the young type 8 (mody8), also known as diabetes and pancreatic exocrine dysfunction (dped), which causes a defect in insulin secretion [31, 32]. |
| PubMedID- 23803251 | Hnf1a: hepatocyte nuclear factor-1alpha; hnf4a: hepatocyte nuclear factor-4alpha; mody: maturity-onset diabetes of the young; psp/reg: pancreatic stone protein / regenerating protein; hscrp: high-sensitivity c-reactive protein; dn: dominant-negative; elisa: enzyme-linked immunosorbent assay; glut-2: glucose transporter 2; ins-1: insulinoma cell line-1; roc: receiver operating characteristic (roc); lda: linear discriminant analysis. |
| PubMedID- 23110382 | Lada (latent autoimmune diabetes in adults), mody (maturity-onset diabetes of the young), pre-diabetes, diabetes in remission. |
| PubMedID- 20938745 | Pndm, permanent neonatal diabetes mellitus; tndm, transient neonatal diabetes mellitus; mody, maturity-onset diabetes of the young; t1bdm, type 1b diabetes mellitusfig. |
| PubMedID- 21390319 | The decreased serum apom level in maturity-onset diabetes of the young subjects as compared to the controls could be explained by the hnf-1 alpha mutations in these patients [28]. |
| PubMedID- 21625646 | It is worth to highlight here the maturity-onset diabetes of the young (mody) and the neonatal diabetes case, as a case study of successful treatment. |
| PubMedID- 22309939 | Kinases in the figure: cdc2l1, cell-division cycle 2-like 1 (pitslre proteins); chek1, chk1 checkpoint homologue (s. pombe); cdc2, cell-division cycle 2, g1 to s and g2 to m; csnk2a2, casein kinase 2, alpha prime polypeptide; dguok, deoxyguanosine kinase; gck, glucokinase (hexokinase 4, maturity-onset diabetes of the young 2); irak1, interleukin-1 receptor-associated kinase 1; map3k4, alpha mitogen-activated protein kinase kinase kinase 4; pdgfra, platelet-derived growth factor receptor, alpha polypeptide; pfkfb2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; pik3c2g, phosphoinositide-3-kinase, class 2, gamma polypeptide; pik4cb, phosphatidylinositol 4-kinase, catalytic, beta polypeptide; phkg2, phosphorylase kinase, gamma 2 (testis); pftk1, pftaire protein kinase 1; plau, plasminogen activator, urokinase; plk1, polo-like kinase 1 (drosophila); prkcd, protein kinase c, delta; skp2: s-phase kinase-associated protein 2 (p45); rps6ka2, ribosomal protein s6 kinase, 90 kda, polypeptide 2; ttk, ttk protein kinase; vrk2, vaccinia-related kinase 2; ihpk1, inositol hexaphosphate kinase 1; pkig, protein kinase (camp-dependent, catalytic) inhibitor gamma; mapk8ip3, mitogen-activated protein kinase 8-interacting protein 3; prkd2, protein kinase d2; pi4k2b, phosphatidylinositol 4-kinase type-ii beta; uck1, uridine-cytidine kinase 1; loc392265, similar to cell-division protein kinase 5 (tau protein kinase ii catalytic subunit) (tpkii catalytic subunit) (serine/threonine-protein kinase pssalre). |
| PubMedID- 23419424 | Patients with normal c-peptide levels, those who were considered to have maturity-onset diabetes of the young (mody) based on the family history and clinical findings, those with t2dm, and those with a chronic disease (such as thalassemia, cystic fibrosis, drug-induced types) were excluded from the study. |
| PubMedID- 20056949 | Subjects who tested positive for anti-gad antibodies and those with mitochondrial disease (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) or maturity-onset diabetes of the young (mody) were not included. |
| PubMedID- 21829439 | maturity-onset diabetes of the young (mody) [28]. |
| PubMedID- 21193628 | They are referred to as maturity-onset diabetes of the young (mody) and are characterized by impaired insulin secretion with minimal or no defects in insulin action. |
| PubMedID- 26442106 | Tested against kegg database, enriched pathways unique to the tumors included abc transporters, lysine degradation, mody (maturity-onset diabetes of the young), pantothenate and coa biosynthesis, cell cycle, and cell adhesion as well as olfactory receptors (table 3). |
| PubMedID- 23282078 | We reported that psmd9 may rarely cause t2d by unique mutations [12] and that is linked to t2d [13], maturity-onset diabetes of the young 3 (mody3) [14], t2d-microvascular [15-18] and t2d-macrovascular complications [19], hypercholesterolemia [20], hypertension [21], carpal tunnel syndrome [22], and depression [23]. |
| PubMedID- 23032149 | Loss-of-function hnf4a mutations cause maturity-onset diabetes of the young type 1 (mody1), which is characterized by progressive β-cell destruction and failure of glucose-induced insulin secretion (70,71). |
| PubMedID- 24497937 | Among these pathways, six (glycolysis/gluconeogenesis, fatty acid metabolism, tyrosine metabolism, pyrimidine metabolism, peroxisome and maturity-onset diabetes of the young) were focused on metabolic pathways. |
| PubMedID- 21324932 | For example, point mutations in the gck gene give rise to maturity-onset diabetes of the young 2 (gck-mody2) in humans and to a similar phenotype in the mouse (e.g. |
| PubMedID- 24023612 | The sequence variations in or near the blk gene have been shown to cosegregate with maturity-onset diabetes of the young (mody) in familial studies. |
| PubMedID- 25598768 | Using wes in the maturity-onset diabetes of the young (mody) patients, the same research group found one mutation (p.glu227lys) in kcnj11, indicating that such mody patients can be ideally treated with oral sulfonylureas [51]. |
| PubMedID- 20226046 | Gad: glutamic acid decarboxylase; gdm: gestational diabetes mellitus; ins: insulin gene; mody: maturity-onset diabetes of the young; pndm: permanent neonatal diabetes mellitus. |
| PubMedID- 23264425 | They are referred to as maturity-onset diabetes of the young (mody) and are characterized by impaired insulin secretion with minimal or no defects in insulin action. |
| PubMedID- 26417406 | Patients who have diabetic conditions other than type 2 diabetes, such as diabetes associated with chronic pancreatitis49, maturity-onset diabetes of the young with hepatocyte nuclear factor-1α (hnf1α) mutation51 and gestational diabetes52, also have the decreased incretin effect. |
| PubMedID- 25619391 | Liraglutide is effective in patients with maturity-onset diabetes of the young (mody) 3, and produces lower hypoglycemic risk than glimepiride9. |
| PubMedID- 22028181 | We tested the hypothesis that gk mutants that cause maturity-onset diabetes of the young (gk-mody) show compromised activity and posttranslational regulation in β-cells. |
| PubMedID- 24586696 | Heterozygous inactivating gck mutations cause maturity-onset diabetes of the young (mody), homozygous or compound heterozygous inactivating mutations cause permanent neonatal diabetes mellitus (pndm), and heterozygous activating mutations cause congenital hyperinsulinism (chi) [10]. |
| PubMedID- 23346354 | Our data is consistent with clinical investigation, in which a dramatic reduction in sp1 binding to gck promoter sequence corresponds to gck-mody (maturity-onset diabetes of the young) cases33. |
| PubMedID- 20571754 | However, it is worth noting that not all glucose-raising loci appear to influence type 2 diabetes risk [11], possibly because some loci may cause modest elevations in glucose concentrations that do not worsen over time, as observed in maturity-onset diabetes of the young [17]. |
| PubMedID- 23610083 | Hepatocyte nuclear factor-1a maturity-onset diabetes of the young (hnf1a-mody) is a monogenic form of non-insulin-dependent diabetes caused by heterozygous mutations in the hnf1a gene (1). |
| PubMedID- 25723573 | In addition to cell-compartmental differences, pathways/processes such as “maturity-onset diabetes of the young (kegg pathways)”, “adipocytokine signalling pathway (kegg pathways)”, and processes involved in pancreas biology and development were found to be significant for the production of sappα but not for sappβ (see s10 supplementary information). |
| PubMedID- 20181263 | Patients with clinical or autoimmune type 1 diabetes and families with known maturity-onset diabetes of the young or mitochondrial dna nucleotide 3243 a > g mutations were excluded. |
| PubMedID- 26417411 | maturity-onset diabetes of the young (mody) is a monogenic form of diabetes that arises from one or more mutations in a single gene, and 13 disease genes for mody have been identified1; for example, the disease gene of mody5 is hnf1b1. |
| PubMedID- 26384018 | Dominant genetic forms that become symptomatic during adolescence or early adulthood are also referred to as maturity-onset diabetes of the young (mody), while neonatal diabetes generally manifests in the first 6 months of life, and can result from dominant as well as recessive mutations24. |
| PubMedID- 23251491 | However, only the maturity-onset diabetes of the young (mody) gene hnf4a[36] and the t2d gene cdkn2a[37] in sat had significant permutation adjusted p-values. |
| PubMedID- 21700917 | maturity-onset diabetes of the young (mody) is a rare monogenic form of diabetes and is often misdiagnosed as type 1 diabetes or type 2 diabetes (1,2). |
| PubMedID- 24734255 | The maturity-onset diabetes of the young (mody) is a familial monogenic form of early-onset type 2 diabetes, which usually develops in childhood, adolescence, or young adulthood [105]. |
| PubMedID- 23033245 | We planned to exclude any autoantibody-negative children with diabetes occurring in three successive generations as suspected mody (maturity-onset diabetes of the young) cases. |
| PubMedID- 21189947 | Mutations in the genes encoding hnf-1β produce an autosomal dominant disorder maturity-onset diabetes of the young, type 5 (mody5), also known as renal cysts and diabetes (rcad), because affected individuals present with severe cystic kidney disease40). |
| PubMedID- 23846810 | Thus patients with maturity-onset diabetes of the young or other specific types of diabetes may have been erroneously diagnosed as having type 2 diabetes and enrolled in this study. |
| PubMedID- 23519111 | Monogenic diabetes, also called maturity-onset diabetes of the young (mody), accounts for about 2%–5% of all diabetic patients [4]. |
| PubMedID- 22355214 | Additionally, mutation in the gene is associated with maturity-onset diabetes of the young type iii (mody3) [16,17], indicating the important biological role of hnf-1α in glucose metabolism. |
| PubMedID- 21709279 | In a separate model, mice exposed to tcdd had reduced glucokinase gene expression (33), predicting a rise in blood glucose levels analogous to that seen in maturity-onset diabetes of the young type 2. others have suggested that the diabetogenic effects of tcdd are mediated through an antagonism of peroxisome proliferator–activated receptor-γ (pparγ) action (34) or through upregulation of the inflammatory adipokine tumor necrosis factor-α (tnf-α) in adipocytes (35). |
| PubMedID- 25621134 | The following were excluded: (i) patients with diabetes undergoing thiazolidinedione therapy; (ii) patients with diagnosed diabetic nephropathy or neuropathy; (iii) patients with acute or chronic inflammatory disease; and (iv) patients with type 1 diabetes, maturity-onset diabetes of the young or mitochondrial diabetes. |
| PubMedID- 22187472 | They are referred to as maturity-onset diabetes of the young (mody) and are characterized by impaired insulin secretion with minimal or no defects in insulin action. |
| PubMedID- 24476040 | Thus, patients previously categorized clinically as having maturity-onset diabetes of the young (mody), permanent neonatal diabetes mellitus (ndm), or transient ndm, can now be classified by genetic sub grouping. |
| PubMedID- 24606082 | maturity-onset diabetes of the young (mody) accounts for approximately 5% of all diabetes cases diagnosed before the age of 45 years (1). |
| PubMedID- 23342076 | Subjects who tested positive for anti-glutamic acid decarboxylase (gad) antibodies and those diagnosed with mitochondrial disease (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes [melas]) or maturity-onset diabetes of the young (mody) were not included. |
| PubMedID- 22065581 | We screened 18 diabetic probands with unelucidated maturity-onset diabetes of the young (mody). |
| PubMedID- 23761103 | By using bioinformatic analysis combined with luciferase-based promoter activity assays and quantitative real-time pcr assays, we identified two maturity-onset diabetes of the young (mody) genes as direct targets of mir-24. |
| PubMedID- 26139844 | 2014), maturity-onset diabetes of the young (johansson et al. |
| PubMedID- 26464794 | Mutations in the hnf1β gene cause maturity-onset diabetes of the young type 5 (mody5), renal cysts, genital malformations, and pancreas atrophy. |