PedAM
Pediatric Disease Annotations & Medicines
| Disease | lung cancer |
| Phenotype | |nsclc |
| Sentences | 62 |
| PubMedID- 22164285 | Among the several pathologies currently treated with cddp, non-small cell lung carcinoma (nsclc), a subtype of lung cancer, is one of the most challenging, due to the high ratio of refractory patients to the current therapy (for a review see [2]). |
| PubMedID- 26035298 | nsclc accounts for ~85% of all lung cancer cases (30) and remains the leading cause of cancer-related death worldwide (31). |
| PubMedID- 24212667 | One particular mirna family, the mir-29 family (comprising mir-29a, -29b, and -29c) has been shown to directly target dnmt3a and -3b and indirectly dnmt1 [25-27], in this regard, the mir-29 family was found to be downregulated in nsclc and enforced expression of mir-29s in lung cancer cell lines restored normal patterns of dna methylation, induced reexpression of methylation-silenced tumor suppressor genes, and inhibited tumorigenicity in vitro and in vivo [25] (table 1). |
| PubMedID- 24695790 | nsclc is any type of epithelial lung cancer other than small cell lung carcinoma (sclc), so we used 16hbe-t which is an immortalized human bronchial epithelial cell line to serve as control for nsclc cell lines. |
| PubMedID- 22263075 | Non small cell lung cancer (nsclc) accounts approximately 80-85% of all lung cancer diagnosis; the majority of patients will be diagnosed with non operable, advanced-stage disease. |
| PubMedID- 25730907 | As for nsclc, about 22%–64% of advanced lung cancer patients will eventually develop bone metastasis [35]. |
| PubMedID- 25709440 | Non-small cell lung carcinoma (nsclc), accounting for 80% of all lung cancers, is a lethal lung disorder because of uncontrollable tumor cell growth and consequent metastasis, invasion of adjacent tissue, and loss of lung function.1–3 according to a recent report, nsclc is expected to cause more than 30% of all cancer-related deaths throughout the world in the near future.4 the conventional therapeutic regimen for nsclc is combined application of surgery and chemotherapy.5 although the majority of solid tumors are able to be removed surgically, chemotherapy is still of great importance for the destruction of residual tumor cells in the body. |
| PubMedID- 26147394 | The nsclc, account for 85% of the lung cancer incidence, and can be further subdivided into three groups: adenocarcinoma, squamous cell carcinoma and large cell carcinoma. |
| PubMedID- 26285137 | nsclc accounts for 80% of lung cancer. |
| PubMedID- 23441611 | nsclc represents the majority of human lung cancers (8). |
| PubMedID- 23833645 | Non-small cell lung carcinoma (nsclc) accounted for ∼85% of the all lung cancer cases (2). |
| PubMedID- 23585862 | While surgical resection is the most effective therapy in nsclc, 75% of patients with lung cancer present with unresectable disease. |
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