PedAM
Pediatric Disease Annotations & Medicines
| Disease | liver disease |
| Phenotype | |cirrhosis |
| Sentences | 175 |
| PubMedID- 24786290 | Liver cirrhosis is a result of advanced liver diseases. |
| PubMedID- 24281095 | Hepatitis b and c viral infection is the most common underlying cause of chronic liver disease leading to liver cirrhosis, and aflatoxin b1 and alcohol are also well-known risk factors. |
| PubMedID- 24905107 | Background: chronic liver disease leads to fibrosis and cirrhosis of the liver. |
| PubMedID- 24719131 | The diagnosis of liver fibrosis and cirrhosis in patients with chronic liver disease is critical, as cirrhotic patients are at higher risk of developing end stage liver disease, portal hypertension, and hepatocellular carcinoma (hcc).1,2 these sequelae are important causes of morbidity, mortality, and increasing health care costs.3,4 the cumulative incidence of hcc is significantly higher in patients with severe fibrosis than in those with no or mild fibrosis.5 thus, the early detection and accurate staging of hepatic fibrosis or cirrhosis has become a critical issue in practice. |
| PubMedID- 21694865 | The mean metavir score was 3.8 ± 0.8 (n = 30, minimum 3, maximum 4), consistent with advanced cirrhosis, a typical feature of end-stage liver disease due to ba. |
| PubMedID- 23243430 | Hepatic fibrosis is a common response to most chronic liver diseases, which may lead to cirrhosis, and cause liver failure as well as increase the risk for hepatocellular carcinoma. |
| PubMedID- 23192205 | Objective: the objective of this study was to determine whether arterial enhancement fraction (aef) is associated with the degree of liver fibrosis and cirrhosis in patients with chronic liver disease. |
| PubMedID- 26215812 | Ccl4 is a potent hepatotoxin commonly used to induce cirrhosis in mouse models of liver disease [29,30], while cisplatin is a chemotherapeutic agent with strong nephrotoxic side effects [31] utilized in mouse models of acute kidney injury (aki) [26,32]. |
| PubMedID- 25635922 | Easl guidelines state that the primary goal of hcv therapy is to cure the infection, which is generally associated with resolution of liver disease in patients without cirrhosis [5]. |
| PubMedID- 20164779 | We assessed the accuracy of liver stiffness measurement, aspartate aminotransferase-to-platelet ratio index (apri) score, 13c-aminopyrine breath test, and indocyanine green plasma clearance for the diagnosis of cirrhosis in patients with chronic liver disease and for the prediction of severe complications in cirrhotic patients. |
| PubMedID- 26473801 | Conclusions: hyperhomocysteinemia is frequently present in patients with cirrhosis and is associated with severe liver disease and reduced graft and patient survival after liver transplantation. |
| PubMedID- 22967278 | Liver cirrhosis, the end-stage of various liver diseases, has a poor prognosis, which is determined by deterioration of hepatic functional capacity and consecutive development of hepatic complications. |
| PubMedID- 24901158 | Background/aims: liver cirrhosis is the end-stage of various liver diseases, which has a poor prognosis and determined by deterioration of hepatic functional capacity and consecutive development of hepatic complications. |
| PubMedID- 21181919 | Multivariate analysis revealed that t1762/a1764 double mutation, hbv/a, age >/=25 years, c1753 and a1899 were critical factors for clinical advancement while age >/=25 years and c1753 as significant predictor for cirrhosis in comparison with chronic liver disease. |
| PubMedID- 24392025 | cirrhosis, the final stage of chronic diffuse liver disease, is histologically defined as the presence of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, resulting in the distortion of the hepatic vasculature and consecutive portal hypertension [1]. |
| PubMedID- 22801423 | Hepatitis c virus (hcv) is the main agent of acute and chronic liver diseases leading to cirrhosis and hepatocellular carcinoma. |
| PubMedID- 25633908 | Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation. |
| PubMedID- 21372348 | Exclusion criteria were previous history of ear disease, active auditory symptoms at the time of recruitment, decompensated cirrhosis, other causes of liver disease, autoimmune disorders and other severe comorbidities such as neoplastic, cardiac, hematologic and psychiatric diseases. |
| PubMedID- 22277039 | C p < 0.0001), indication for surgery [prevention of bleeding recurrence differed from refractory ascites (p = 0.0001) and the indication to stop acute bleeding (p = 0.026)]; aetiology of the liver disease [patients with alcoholic cirrhosis differed from patients with budd-chiari syndrome (p < 0.0001) and from patients with chronic viral hepatitis (p = 0.024)]. |
| PubMedID- 25945106 | Liver fibrosis represents the final common pathway of chronic liver diseases and eventually leads to cirrhosis and its complications including liver failure and hepatocellular carcinoma [1, 2]. |
| PubMedID- 25191479 | Significant reductions in serum and tissue aat levels in human beings are associated with chronic obstructive pulmonary disease (copd) especially pulmonary emphysema and liver disease which can lead to cirrhosis, necrotizing panniculitis and vasculitis (3, 4). |
| PubMedID- 26117383 | Severe mdr3 deficiency typically presents during the first year of life or early childhood, often progressing to chronic liver disease with cirrhosis and portal hypertension, requiring liver transplantation. |
| PubMedID- 22848732 | However, te and arfi (right liver lobe) distinguished between liver cirrhosis and earlier stages of liver disease in cfld patients. |
| PubMedID- 26473344 | Nonalcoholic fatty liver disease (nafld) can lead to cirrhosis, hepatocellular carcinoma, and ultimately death. |
| PubMedID- 24490061 | Most patients had cirrhosis due to alcoholic liver disease (table 1). |
| PubMedID- 25849950 | Fatty liver disease can lead to steatohepatitis, fibrosis, cirrhosis, and even cancer, which is associated with various complications. |
| PubMedID- 24282628 | Nash, but not simple steatosis, is a potentially progressive liver disease leading to cirrhosis and hepatocellular carcinoma [31]. |
| PubMedID- 23819582 | Hcc is often complicated by cirrhosis, so treatment of the underlying liver diseases is also necessary to improve the prognosis. |
| PubMedID- 26441244 | Non-alcoholic steatohepatitis (nash), as an extreme form of nafld, is associated with progressive liver disease and can lead to cirrhosis and ⁄ or hepatocellular carcinoma [1,2]. |
| PubMedID- 25089192 | Obesity is associated with dyslipidemias, hyperinsulinemia and hypertension, increasing risks for premature heart disease and stroke, many cancers, bone and joint problems, sleep apnea, asthma and other breathing problems, gall bladder disease, liver disease leading to cirrhosis, depression and eating disorders, genitourinary problems, pregnancy complications, central nervous system problems and more, many of which are now starting to be seen in children and adolescents.3 these trends are already showing up as increased medical care costs for children and adolescents.4 the overall medical care costs of obesity in the united states already exceed $140 billion per year.5 as a result, the obesity epidemic may be one of the most challenging and serious medical and public health problems of the twenty-first century. |
| PubMedID- 21697972 | Our patient had an ill-defined chronic liver disease with no cirrhosis on biopsy, was on a low and tapering dose of steroids for a short period of time, and was taking 6-mp. |
| PubMedID- 26362514 | The diagnosis requires the exclusion of cirrhosis, common causes of chronic liver disease and venous obstruction of the portal and hepatic veins. |
| PubMedID- 23577631 | About 20-30% of patients could develop a progressive liver disease leading to cirrhosis and hcc [5,7]. |
| PubMedID- 20174556 | The hepatitis c virus (hcv) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma [1]. |
| PubMedID- 23449255 | Chronic alcohol consumption is a leading cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. |
| PubMedID- 20600032 | Background & aims: autoimmune hepatitis (aih) is a chronic liver disease associated with cirrhosis and liver failure. |
| PubMedID- 22567408 | Until recently, transplantation was considered the only viable treatment option for cirrhosis and severe forms of liver disease [55]. |
| PubMedID- 22052005 | Recent studies have shown that the pathogenetic pathways of chronic fibrotic liver disease leading to cirrhosis are identical in man and dog (ijzer et al. |
| PubMedID- 21852972 | The associations with hepatocellular carcinoma (pon1) and cholangiocellular carcinoma (pon3) also seem to be plausible as paraoxonases have a protective effect against oxidative stress, which plays an important role in chronic liver diseases leading to liver cirrhosis and the development of carcinomas (camps et al., 2009). |
| PubMedID- 22412837 | Exclusion criteria included cirrhosis, the presence of other liver diseases, diabetes, pregnancy, significant clinical co-morbidities, and the inability to provide informed consent. |
| PubMedID- 25821463 | Patients were excluded if they had hcv genotype other than type 1 infection (i.e., hcv types 2–6), biopsy-proven cirrhosis, other causes of liver disease, hepatitis b virus infection, human immunodeficiency virus infection, autoimmune disorders, clinically significant cardiac or cardiovascular abnormalities, organ grafts, systemic infections, clinically significant bleeding disorders, evidence of malignant neoplastic diseases, concomitant immunosuppressive medication, fasting glucose levels >7 mmol/l or glucose levels >11.1 mmol/l at 2 hours after an oral intake of 75 grams of glucose (oral glucose tolerance test) or glycosylated hemoglobin > 48 mmol/mol (6.5%) or antidiabetic treatment, or any alcohol intake or drug abuse within the six months prior to study entry. |
| PubMedID- 25175670 | Case presentation: a 76-year-old caucasian man with liver cirrhosis due to non-alcoholic fatty liver disease, and type-2 diabetes was cognitively impaired and had reduced vigilance presumably caused by hepatic encephalopathy and/or alzheimer dementia. |
| PubMedID- 26076199 | Liver fibrosis is a common feature of almost all causes of chronic liver disease, and eventually leads to cirrhosis [1, 2]. |
| PubMedID- PMC4070603 | So, marked increase in serum levels are noted in liver diseases, especially in patients with cirrhosis, when the clearance is impaired. |
| PubMedID- 26274335 | Nafld was also defined by clinical diagnosis (cryptogenic cirrhosis, obese-diabetics with cryptogenic liver disease). |
| PubMedID- 24008520 | Other possible reasons include differences in the causes of the underlying liver diseases, and patients with cirrhosis tending to have higher afp levels than those with chronic hepatitis [36,41]. |
| PubMedID- 26188836 | Abnormal liver function test results and alterations in serum liver enzyme markers (eg, alanine and aspartate transaminases) may suggest cirrhosis in patients with chronic liver disease; however, they are not definitive. |
| PubMedID- 20070500 | Different from western countries where alcoholic cirrhosis constitutes 50–70% of all underlying liver diseases in china, hepatitis b-related aclf (hb-aclf) cases account for more than 80% of aclf cases as a result of the high incidence of chronic hbv infection [4,5]. |
| PubMedID- 22645408 | Exclusion criteria: hcv-infected patients treated with interferon α in the past six months or less, liver cirrhosis, other types of hepatitis or liver disease of different etiology, other infectious diseases, overt cardiovascular disease (based on documented history and ecg examination), endocrine diseases, lung disease, renal dysfunction (serum creatinine level >2.0 mg/dl), presence or history of neoplastic diseases, pregnant or postpartum women, and present or past history of alcohol or drug abuse. |
| PubMedID- 23178709 | Background & aims: autoimmune hepatitis is a chronic inflammatory liver disease that leads to liver cirrhosis and corresponding complications, if left untreated. |