PedAM
Pediatric Disease Annotations & Medicines
| Disease | colorectal cancer |
| Phenotype | |liver metastases |
| Sentences | 110 |
| PubMedID- 20569442 | liver metastases of 6 colorectal cancers (20.7%) had a mean pmr of 39.23% (range 25.18 to 52.18%). |
| PubMedID- 22096485 | We investigated the effect of this protease on cell migration and angiogenesis in vitro and studied the expression of meprin-alpha mrna, protein and proteolytic activity in primary tumors at progressive stages and in liver metastases of patients with colorectal cancer, as well as inhibitory activity towards meprin-alpha in sera of cancer patient as compared to healthy controls. |
| PubMedID- 24953371 | Objective: to investigate the association between expression of hepatocyte growth factor(hgf) and its receptor c-met and primary colorectal cancers with synchronous liver metastases. |
| PubMedID- 25456112 | Backgrounds: the prognostic value of biomarkers in metastatic colorectal cancer (mcrc) patients with liver metastases remains unclear. |
| PubMedID- 23442595 | The fact that liver metastases of colorectal cancer do not take up lipid pet tracers has already been published [11]. |
| PubMedID- 24452736 | Leggett et al (14) reported that the use of ctp in colorectal cancer patients with simultaneous liver metastases revealed that the hepatic arterial blood flow was significantly increased and the portal blood flow was decreased. |
| PubMedID- 21159103 | Laparoscopic combined resection in primary colorectal cancer with synchronous liver metastases has been reported but there are no specific data for major liver resections. |
| PubMedID- 21937374 | Methodology: we randomly selected 114 colorectal cancer patients with liver metastases and 114 patients without liver metastasis. |
| PubMedID- 23203441 | Case no.1: a 67-year-old caucasian male was diagnosed of colorectal cancer with liver metastases without severe cardiovascular disease in history. |
| PubMedID- 26452624 | Conclusions: haic was effective in some systemic chemotherapy-resistant colorectal cancers with liver metastases and should be considered as an effective palliative therapy. |
| PubMedID- 25253940 | colorectal cancer with liver metastases: neoadjuvant chemotherapy, surgical resection first or palliation alone. |
| PubMedID- 20544397 | Impact of resection for primary colorectal cancer on outcomes in patients with synchronous colorectal liver metastases. |
| PubMedID- 21764578 | Conclusions: cd133 and cd44 proteins were highly co-expressed in colorectal cancer with early liver metastases, and may be a potential biomarker for the early liver metastases. |
| PubMedID- 25469725 | Ten colorectal cancer patients with liver metastases received between one and five doses of oncolytic reovirus prior to surgical resection of their tumour. |
| PubMedID- 20728416 | Further studies are needed to better delineate innovative therapeutic strategies that may lead to an improved outcome for colorectal cancer patients with surgically resectable liver metastases. |
| PubMedID- 25319712 | Purpose: the first aim of the review (aim 1) was to obtain the diagnostic performance values of (18)f-fdg pet for the detection and staging of liver metastases in patients with colorectal cancer (crc), the second aim (aim 2) was to compare pet and conventional imaging modalities, and the third aim (aim 3) was to evaluate the impact of pet on patient management. |
| PubMedID- 20412096 | Aim: this study compared the sensitivity and specificity of contrast-enhanced ultrasound (ceus) and multidetector-computed tomography (mdct) in the detection of liver metastases in patients with colorectal cancer. |
| PubMedID- 22874690 | Background: the laparoscopic resection of colorectal cancer (crc) along with synchronous liver metastases has been attempted and reported in multiple single series. |
| PubMedID- 25992208 | Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. |
| PubMedID- 20841952 | Both were advanced colorectal cancer cases with liver metastases, so we started chemotherapy with modified folfox6+bevacizumab. |
| PubMedID- 24693879 | Nine male patients with liver metastases of colorectal cancer were included retrospectively (age 48 to 76 years (mean 62.8), weight 73 to 100 kg (mean 85.5)). |
| PubMedID- 22202333 | In this study, we retrospectively analyzed the efficacy of mfolfox6 in colorectal cancer patients with synchronous unresectable liver metastases and compared the prognosis between before and after the administration of mfolfox6. |
| PubMedID- 23010733 | colorectal cancer with synchronous resectable liver metastases: monocentric management in a hepatobiliary referral center improves survival outcomes. |
| PubMedID- 25040974 | Materials and methods: ninety-nine patients who underwent metastasectomy for liver metastases due to colorectal cancer at the department of medical oncology, 9 eylul university hospital between 1996 and 2010 were evaluated in this study. |
| PubMedID- 23611316 | The cost-effectiveness of ceus was modelled separately for the three main clinical applications considered [characterisation of flls detected on ultrasound surveillance of cirrhosis patients, detection of liver metastases in patients with colorectal cancer (crc), characterisation of incidentally detected flls]. |
| PubMedID- 24091673 | Although 5-fu has been reported to induce apoptosis via the fas pathway in liver metastases of colorectal cancer patients,56 and stimulate p-jnk in colorectal cancer cells,57 our current results suggest the probable existence of a fas/jnk-independent mechanism in chemotherapy of 5-fu, as well as the importance of fas/jnk pathway in protection against apoptosis by adma. |
| PubMedID- 24292449 | Likewise, stromal angiopoietin-2, which is currently tested as a target for antitumour in clinical trials (mita et al, 2010; karlan et al, 2012), shows an approximately four-fold increase in colorectal liver metastases compared with primary colorectal cancer, and a two-fold upregulation in liver metastases vs lung metastases. |
| PubMedID- 22437957 | The purpose of this study was to evaluate totally laparoscopic strategies in the management of colorectal cancer with synchronous liver metastases. |
| PubMedID- 22966429 | Reported that the 2-year local control and 2-year survival rates in colorectal cancer patients with liver metastases (i.e., mostly colorectal cancer) were 74% and 83%, respectively, after treatment with sbrt using mainly 37.5 gy/3 fr [43]. |
| PubMedID- 22862882 | Furthermore the surgical indications for liver metastases of colorectal cancer have been expanded to include all technically resectable metastases numbering 4 or more [10]. |
| PubMedID- 25596059 | Although the first-line treatment for liver metastases arising from colorectal cancer is surgery, it is unknown whether this treatment is equally effective for liver metastases with peritoneal dissemination. |
| PubMedID- 24142639 | For western blot analysis, tissue samples were obtained from 10 colorectal cancer patients with synchronous liver metastases, who underwent surgical resection at the national cancer center, korea. |
| PubMedID- 25580640 | Cxcr2, cxcr4, and their chemokine ligands were evaluated in liver metastases of colorectal cancer in order to study their correlation with overall and disease-free survival of patients having received, or not received, a neoadjuvant chemotherapy regimen. |
| PubMedID- 23927554 | Extensive experience with the technique has been gained in patients with isolated liver metastases of colorectal cancer (crc). |
| PubMedID- 23116727 | The goal of this study is to assess the value of positron emission tomography/computed tomography with 18f-fluorodeoxyglucose (18f-fdg pet/ct) in the decision making whether to perform rfa or surgical resection of liver metastases in patients with metastatic colorectal cancer. |
| PubMedID- 25915155 | Objective: in this study, we evaluate the frequency of her-2 and her-3 expression in liver metastases from patients with colorectal cancer (crlm). |
| PubMedID- 24959270 | No significant differences were observed in the liver metastases of colorectal cancer with regard to gender, age, number of lesions, lesion size and pathological differentiation (p>0.05). |
| PubMedID- 26094113 | Aims: the purpose of this meta-analysis is to assess the value of peri-operative chemotherapy for patients who have resectable colorectal cancer with liver metastases (crclm). |
| PubMedID- 23241814 | [liver-first management for colorectal cancer with simultaneous liver metastases. |
| PubMedID- 25815009 | This retrospective study reports a single institution's experience of tace for metastatic colorectal cancer (mcrc) patients with unresectable liver metastases in a real-life setting. |
| PubMedID- 24652674 | Background: the optimal management of colorectal cancer with synchronous liver metastases has not yet been elucidated. |
| PubMedID- 22082538 | Objective: the objectives of the study were to determine whether perfusion computed tomography (ct-p) and magnetic resonance diffusion-weighted imaging (mr-dwi) can allow evaluation of the effects of chemotherapy combined with antiangiogenetic treatment on liver metastases in patients with advanced colorectal cancer and to determine if changes in ct-p and mr-dwi correlate with the response to therapy as assessed by conventional response evaluation criteria in solid tumors (recist). |
| PubMedID- 20154497 | Such a strategic multidisciplinary treatment can lead to a better prognosis for colorectal cancer with liver metastases. |
| PubMedID- 22403631 | [25] investigated the influence of the egf 61*a/g polymorphism on the recurrence of liver metastases in patients with colorectal cancer and was excluded. |
| PubMedID- 26055754 | Of these patients, 12 patients had hepatocellular carcinoma, while seven patients had liver metastases of colorectal cancer (crc). |
| PubMedID- 23075717 | Folfox4 regimen administered through combined hepatic arterial and systemic infusion for treatment of colorectal cancer with unresectable liver metastases. |
| PubMedID- 26203228 | In secondary cancer in liver (for instance, liver metastases of colorectal cancer), expression of nuclear cxcr4 is associated with better survival, whereas the expression of cytoplasmic cxcr4 with worse prognosis. |
| PubMedID- 26056460 | The process of liver regeneration and tumor recurrence after partial hepatectomy performed in colorectal cancer patients with liver metastases is associated with an increase in the intrahepatic levels of ace in mouse models. |
| PubMedID- 25666309 | liver metastases in colorectal cancer patients decreases the expected 5 year survival rates by a factor close to nine. |
| PubMedID- 24889770 | Management of colorectal cancer presenting with synchronous liver metastases. |