PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | |cleft palate |
| Sentences | 332 |
| PubMedID- 25220223 | Objectives: nonsyndromic cleft lip with or without cleft palate (nscl/p) is a common birth defect which is strongly associated with genetic factors. |
| PubMedID- 24582076 | 83% of the cases (n = 44) involved some form of cleft lip with or without cleft palate. |
| PubMedID- 20507242 | The overall prevalence of cleft lip with or without cleft palate was 9.92 per 10,000. |
| PubMedID- 21112484 | Genome-wide and interaction linkage scan for nonsyndromic cleft lip with or without cleft palate in two multiplex families in shenyang, china. |
| PubMedID- 25471993 | cleft lip with or without cleft palate (clp and cl, respectively) and isolated cleft palate (cp) represent one of the most common human birth defects, with a prevalence of approximately 1 in 300-2500 depending on the population. |
| PubMedID- 24131571 | In addition, we observed modest increases in the risk for spina bifida, cleft lip with or without cleft palate, and limb reduction defects in offspring of women who showered >/=15 compared to <15 minutes. |
| PubMedID- 24252547 | Summary non-syndromic oral clefts comprising cleft lip with and without cleft palate (cl/p) and cleft palate only (cpo) are common birth defects worldwide. |
| PubMedID- 22490406 | Background: the receptor tyrosine kinase-like orphan receptor 2 (ror2) gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in humans. |
| PubMedID- 26424980 | Single nucleotide polymorphism of bmp4 gene: a risk factor of non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 20544801 | Background: cleft lip with or without cleft palate (cl/p) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. |
| PubMedID- 23132150 | The fact that the rrr for cleft palate with cleft lip was highest in the present study supports their results. |
| PubMedID- 24382704 | Evaluating eight newly identified susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a mesoamerican population. |
| PubMedID- 25613075 | cleft lip with or without cleft palate is one of the most common birth defects of unknown etiology. |
| PubMedID- 20081540 | Maternal passive smoking and risk of cleft lip with or without cleft palate. |
| PubMedID- 21980401 | Understanding these processes has considerable importance for human health, as failure of the facial prominences to fuse is often the underlying cause of midfacial clefting defects including cleft lip with or without cleft palate - the most common form of human craniofacial birth defect [8], [9], [10]. |
| PubMedID- 25339627 | Association between noggin and spry2 polymorphisms and nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 21434540 | The eec syndrome, consisting of ectrodactyly (e), ectodermal dysplasia (e) and cleft lip (c) with or without cleft palate, is the prototype of these syndromes with the presence of heterozygote mutation in the p63 gene in most of the patients. |
| PubMedID- 21290562 | Results: risk of all clefts combined, including cleft lip with or without cleft palate (cl/p) and cleft palate only (cp), was 65% lower in the highest versus lowest pf quartile (odds ratio [or], 0.35; 95% confidence interval [ci], 0.23-0.53; p-trend < 0.001). |
| PubMedID- 24838934 | Nucleotide variants of the cancer predisposing gene cdh1 and the risk of non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 22044123 | Case-control and family-based association studies of novel susceptibility locus 8q24 in nonsyndromic cleft lip with or without cleft palate in a southern han chinese population located in guangdong province. |
| PubMedID- 21565678 | Objective: convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate (nscl/p) and low intake of folic acid by the mother during pregnancy. |
| PubMedID- 24380661 | The aim of our study was to determine whether there is any association between the susceptibility to nonsyndromic cleft lip with or without cleft palate (nscl/p) amongst the variations of mthfr genotypes in south indian population. |
| PubMedID- 25721952 | We stratified the descriptive results by cleft type [cleft lip with cleft palate, cleft lip, and cleft palate] and by isolated versus nonisolated ofc (accompanied by other coded major birth defects). |
| PubMedID- 23551076 | Background: cleft lip, with or without cleft palate (cl+/-p), is the most common craniofacial anomaly in newborns. |
| PubMedID- 22674314 | Results: in the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. |
| PubMedID- 22438645 | Found a positive association between systemic corticoids use and the occurrence of cleft lip with or without cleft palate. |
| PubMedID- 26204535 | Background: nat genes are considered candidate genes for the genetic predisposition to non-syndromic cleft lip with or without cleft palate (nsclp), since they codify for n-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. |
| PubMedID- 25711982 | The highest elevations in sex ratios (i.e., male preponderance) among isolated non-cardiac defects were for craniosynostosis (2.12), cleft lip with cleft palate (2.01), and cleft lip without cleft palate (1.78); the lowest sex ratios (female preponderance) were for choanal atresia (0.45), cloacal exstrophy (0.46), and holoprosencephaly (0.64). |
| PubMedID- 25713581 | Models were run on cleft lip with or without cleft palate families amongst (a) asians and caucasians, (c) asians only, (e) caucasians only, as well as cleft palate only families amongst (b) asian and caucasians, (d) asians only, (f) caucasians only. |
| PubMedID- 22487822 | Objective: to assess the association between polymorphism of interferon regulatory factor 6 (irf6) gene rs2235371 locus and nonsyndromic cleft lip with or without cleft palate in chinese population. |
| PubMedID- 23017738 | Results: forty-three cases of fetal cleft lip with or without cleft palate were reviewed. |
| PubMedID- 20572780 | cleft lip associated with cleft palate (clp) was the most common type of anomaly (53.5%), followed by isolated cleft lip (cl; 28.7%) and isolated cleft palate (cp; 17.8%). |
| PubMedID- 25577202 | However, the following prevalences were higher in norway: transposition of great vessels (0.21/1000), cleft lip with or without cleft palate (1.36/1000), down syndrome (1.34/1000), and lower for congenital hydrocephalus (0.43/1000) [21]. |
| PubMedID- 22125225 | The practical relevance of the approach is illustrated by an application to a sequencing dataset for nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 23577250 | cleft lip with cleft palate amounted to 198 (53.5%), cleft palate to 99 (26.8%), and cleft lip to 73 (19.7%) cases. |
| PubMedID- 23385809 | Lower incidence of nonsyndromic cleft lip with or without cleft palate in females: is homocysteine a factor. |
| PubMedID- 22514733 | As the lip and primary palate have distinct developmental origins from the secondary palate, clefts of these areas can be further subdivided into cleft lip with or without cleft palate and cleft palate alone to maximize homogeneity of cleft phenotype [8]. |
| PubMedID- 23555592 | Data analyzed include number of live births, stillbirths, nationality of mother and spouse, gender of neonate, gestational age at birth (in weeks), birth weight (g), parity (first child, second, other) and congenital defects (cl/p (cleft lip with or without cleft palate: [code 0203]; cp (no cleft lip): [code 0204]; other congenital anomalies). |
| PubMedID- 25250270 | Also, canfiled et al (2005) from the national birth defects prevention network using data from multiple state registries found a 5% decline in cleft lip with or without cleft palate post-fortification (29). |
| PubMedID- 21792966 | Objectives/hypothesis: cleft lip with or without cleft palate (cl/p) is a common birth defect throughout the world. |
| PubMedID- 22984993 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common of all congenital malformations and has a multifactorial etiology. |
| PubMedID- 25496823 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is a common birth defect results from the genetic factors alone or interactions with environmental changes. |
| PubMedID- 19860507 | Filipino explanatory models of cleft lip with or without cleft palate. |
| PubMedID- 25163644 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is a common birth defect of complex etiology. |
| PubMedID- 23893927 | Methods: data on 6045 nonsyndromic isolated oral cleft cases (3915 cleft lip with or without cleft palate [cl +/- p] and 2130 nonsyndromic isolated cleft palate [cp] cases) delivered between 1999 and 2008 were obtained from the texas birth defects registry. |
| PubMedID- 23181832 | The overall goal of this randomized, double-blinded study is to reduce the recurrence of non-syndromic cleft lip with or without cleft palate (nscl/p) in a high-risk group of women supplemented with folic acid from preconception and continuing throughout the first three months of pregnancy. |
| PubMedID- 22492558 | Investigation of sumo pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 23679094 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is the most common orofacial birth defect with a wide range prevalence among different populations. |
| PubMedID- 22404957 | Objective : to evaluate the long-term maxillomandibular changes after maxillary distraction osteogenesis in growing children having cleft lip with or without cleft palate. |
| PubMedID- 26313826 | Prenatal ultrasound diagnosis of cleft lip with or without cleft palate has received little attention in the plastic surgery literature despite its initial description more than 30 years ago. |