PedAM
Pediatric Disease Annotations & Medicines
| Disease | c syndrome |
| Phenotype | |obesity |
| Sentences | 377 |
| PubMedID- 25490708 | Elevated ggt can signal liver injury generally, and non-alcoholic fatty liver disease associated with abdominal obesity and other features of the metabolic syndrome [39]. |
| PubMedID- 20418190 | After excluding patients with potential monogenic syndromes or diseases associated with obesity, we evaluated the association of the single nucleotide polymorphisms (snps) rs1861868 and rs9939609 of the fat-mass and obesity-associated fto gene with an inherited predisposition to morbid obesity. |
| PubMedID- 20230058 | When ep was given at low, medium, and high dosages (94, 188, and 470 mg/kg) to sucrose water-treated wistar rats for four weeks, alleviation of symptoms associated with metabolic syndrome, including obesity, insulin resistance, hypertriglyceridemia, and hypertension, accompanied by hepatic acc inactivation, was seen in the low dosage group. |
| PubMedID- 20224753 | It is also recognized that many subjects with osa have central obesity and other features of metabolic syndrome [39], which is most widely accepted as being comprised of hyperinsulinemia, glucose intolerance, dyslipidemia, central obesity, and hypertension [58]. |
| PubMedID- 20852030 | The risk of diabetes was higher in the overweight and obesity categories and with prevalent metabolic syndrome compared with that for normal-weight individuals without the metabolic syndrome in both crude and multivariable models with adjustment for age at baseline, smoking status, and physical activity (table 3). |
| PubMedID- 22998770 | However, annotated functional classifications might provide an important reference resource to understand the pathogenesis of obesity associated with the metabolic syndrome. |
| PubMedID- 24204674 | obesity is strongly associated with metabolic syndrome, hypertension, dyslipidemia and hyperglycemic tendencies that are represented at the molecular level by insulin resistance (ir) [1]. |
| PubMedID- 21351667 | obesity is a part of the metabolic syndrome and an independent mortality risk factor in all age categories, however, this relation is twice as strong in individuals under fifty years of age. |
| PubMedID- 24410812 | Lactoferrin (lf), a multifunctional glycoprotein in mammalian milk, is reported to exert a modulatory effect on lipid metabolism and improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. |
| PubMedID- 22905200 | The specific questions we set out to address in this report were: (1) what are the major gut microbial subpopulations in this population and how does their distribution vary in obesity and with metabolic syndrome phenotypes? |
| PubMedID- 24674634 | Results from screenings identified high obesity rates, high prevalence of metabolic syndrome, low fruit and vegetable consumption, and low use of preventive medical therapies as interventions for priority risk factors (12,13). |
| PubMedID- 22075986 | More recently, jurg introduced the critical new concept of the metabolic inflammasome, which senses metabolic stress and contributes to the onset of the metabolic syndrome associated with obesity and type 2 diabetes. |
| PubMedID- 25965509 | Fructose has been confirmed to induce several obesity-related complications associated with the metabolic syndrome. |
| PubMedID- 21250778 | Genetic variation at the cd36 loci have been associated with obesity and lipid components of the metabolic syndrome, with risk of heart disease and type 2 diabetes. |
| PubMedID- 22125461 | Hbot has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress. |
| PubMedID- 23942780 | Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associated with increased systemic and tissue levels of ang ii. |
| PubMedID- 22301857 | In rodents, a high-fat and high-fructose diet has been shown to result in metabolic syndrome with obesity and changed body composition64, 65. in a study by shapiro et al, it was shown that feeding sd rat with fructose caused leptin resistance, which led to an exacerbated weight gain when also given a high-fat diet, suggesting that fructose increases the propensity for obesity development66. |
| PubMedID- 26078820 | Nafld, as a hepatic manifestation of metabolic syndrome, is associated with dyslipidemia, obesity, insulin resistance, and type 2 diabetes mellitus [1, 2]. |
| PubMedID- 21396586 | This review describes the genetic syndromes associated with obesity and overgrowth. |
| PubMedID- 23903497 | Results: multiple logistic regression analysis revealed that visceral obesity was independently associated with metabolic syndrome, platelet count, high-density lipoprotein level, and serum viral load in elderly patients (>/=65 years). |
| PubMedID- 25648511 | Fibre is the largest component of the seaweed biomass [10,11] and therefore may be present in sufficient amounts when included in the diet to prevent metabolic syndrome associated with obesity, type 2 diabetes and cardiovascular complications [12]. |
| PubMedID- 23900353 | Hyperuricemia and its association with obesity and various components of metabolic syndrome have been documented in previous studies. |
| PubMedID- 24217719 | Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic syndrome. |
| PubMedID- 25760026 | Insulin resistance is a common pathological state found in the metabolic syndromeassociated with obesity and type 2 diabetes mellitus, in which target tissues fail torespond properly to physiologic insulin levels (5,7). |
| PubMedID- 26317527 | Dysregulated glucose homeostasis and obesity are key components of the metabolic syndrome (mets). |
| PubMedID- 24741661 | [2] metabolic syndrome is associated with overweight and obesity and on the other hand is a risk factor for cardiovascular disease and diabetes too. |
| PubMedID- 21756079 | Objective: based on the role of polycystic ovary syndrome as a cause of metabolic syndrome with chronic anovulation, obesity, hyperinsulinemia and hyperandrogenism, development of effective treatment for its obesity is a priority. |
| PubMedID- 23610524 | Interestingly, in the study by forest et al5 aimed to determine a potential relationship between the onset of gestational hypertension and the presence of metabolic syndrome, with obesity and diabetes being the two main entities of this syndrome. |
| PubMedID- 22029024 | [40] truncal obesity is associated with metabolic syndrome and insulin resistance. |
| PubMedID- 24843681 | We recruited 204 healthy reference individuals with normal glucose tolerance without obesity, any component of metabolic syndrome or elevated alanine aminotransferase. |
| PubMedID- 26295946 | obesity is the hallmark of metabolic syndrome and predisposes patients to the development of major chronic metabolic disease including type 2 diabetes. |
| PubMedID- 26558010 | Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic–pituitary–testicular axis, leading to diminished testosterone production. |
| PubMedID- 23173761 | Pcos is a hyperinsulinemic syndrome strongly associated with obesity and type 2 diabetes mellitus and has also been associated with high blood pressure, dyslipidemia and cardiovascular disease[2]. |
| PubMedID- 22360800 | Although insulin resistance is a key component of several chronic syndromes associated with obesity such as type 2 diabetes mellitus and metabolic syndrome, the involved factors and their underlying mechanisms linking excessive adiposity to insulin resistance were not completely elucidated yet [2-5]. |
| PubMedID- 22967456 | In addition, it has been reported that prenatally undernourished rats nursed by control mothers exhibit a rapid catch-up growth and are more susceptible to developing obesity and features of metabolic syndrome [58]. |
| PubMedID- 22518352 | [2] the prevalence of the metabolic syndrome is increasing because of the ‘obesity epidemic.’[3] the increased prevalence of obesity has been accompanied by a parallel increase in the prevalence of the metabolic syndrome. |
| PubMedID- 22744625 | The aim of our study was to investigate if vitamin d deficiency without diabetes mellitus and metabolic syndrome is associated with obesity and abdominal obesity. |
| PubMedID- 22315154 | Aim: the aim of this study was to determine the prevalence of erectile dysfunction (ed), testosterone deficiency syndrome (tds), and metabolic syndrome in patients with abdominal obesity (ao) and the prevalence of morbidity at different levels of testosterone (tst). |
| PubMedID- 26464753 | The pathogenesis of nafld associated non-cirrhotic hcc is distinct from that of cirrhotic hcc because the metabolic syndrome (ms) along with obesity and insulin resistance (ir) underlie several unique mechanisms that promote tumorigenesis. |
| PubMedID- 23133447 | Metabolic syndrome is strictly associated with morbid obesity and leads to an increased risk of cardiovascular diseases and related mortality. |
| PubMedID- 20302640 | In addition, cerebellar degeneration can be caused by systemic diseases such as diabetes mellitus [74], chronic alcoholism [75], or obesity with metabolic syndrome [45,46]. |
| PubMedID- 22125453 | A second hypothesis is that obesity, being associated with metabolic syndrome, results in increased circulating levels of insulin and insulin-like growth factor (igf), which, by acting as mitogens for epithelial breast cells, stimulate their growth and neoplastic degeneration. |
| PubMedID- 21147557 | Conclusions: the high prevalence of biochemical and physiological factors of metabolic syndrome, associated with overweight and obesity in mexico city adolescents, increases the risk of premature development of coronary atherosclerosis and diabetes mellitus in this population. |
| PubMedID- 26167390 | Metabolic syndrome, mainly obesity, plays an important role, both as an independent risk factor and in the pathogenesis of nafld. |
| PubMedID- 23374911 | This aim of this study was to further examine adipocytokines and other metabolic and immune biomarkers of metabolic syndrome linked with obesity in patients with early breast cancer prior to therapy initiation. |
| PubMedID- 24416020 | Here we investigated the effects of chronic treatment with the novel selective oxr-1 antagonist act-335827 in a rat model of diet-induced obesity (dio) associated with metabolic syndrome (mets). |
| PubMedID- 23227310 | Atypical or second-generation antipsychotics are especially associated with obesity and other components of metabolic syndrome, particularly abnormal glucose and lipid metabolism [9]. |
| PubMedID- 22115311 | Interestingly, mice genetically deficient in tlr-5 have an altered gut microbiota composition that correlates with obesity and several features of the metabolic syndrome including hyperlipidemia, hypertension, and insulin resistance, which could at least in part be attributed to increased food consumption [59]. |
| PubMedID- 24170999 | In our previous study, the serum bmp-4 level was associated with obesity and the presence of metabolic syndrome [4]. |
| PubMedID- 20532017 | In female cases, the incidence of metabolic syndrome associated with obesity after menopause increases rapidly, primarily because of the accumulation of abdominal body fat due to the sudden reduction in estrogen secretion caused by menopause [27]. |