PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Phenotype | |obesity |
| Sentences | 117 |
| PubMedID- 21772329 | The increase in risk of postmenopausal breast cancer associated with obesity may be largely explained by the relatively high circulating concentrations of free oestradiol in obese postmenopausal women (endogenous hormones and breast cancer collaborative group, 2003a; rinaldi et al, 2006), but it is unclear to what extent the effects of other risk factors may be mediated by their associations with circulating sex hormones. |
| PubMedID- 22268396 | Regardless of menopausal status, obesity is associated with breast cancers that exhibit aggressive biological characteristics at the time of diagnosis and have a poor prognosis; a similar relationship is emerging for type 2 diabetes. |
| PubMedID- 21467202 | Greater bmi and obesity are associated with decreased breast cancer risk in studies of premenopausal women (friedenreich, 2001; berstad et al., 2010) while both current and former oc users have an increased risk of breast cancer in recent studies (lund et al., 2007; hunter et al., 2010). |
| PubMedID- 26385214 | Thus, it seems surprising that we did not find a significant effect of obesity on survival in patients with breast cancer of the hormone receptor-positive luminal a and luminal b subtype. |
| PubMedID- 25339024 | Relation of serum adiponectin levels and obesity with breast cancer: a japanese case-control study. |
| PubMedID- 24375928 | Pooled analysis yielded a summary risk ratio of 0.78 (95% confidence interval (ci): 0.67, 0.92) for hormone receptor-positive premenopausal breast cancer associated with obesity (body mass index (weight (kg)/height (m)(2)) >/=30 compared with <25). |
| PubMedID- 25884832 | Association of high obesity with pam50 breast cancer intrinsic subtypes and gene expression. |
| PubMedID- 25583948 | Background: although obesity is associated with breast cancer incidence and prognosis, the underlying mechanisms are poorly understood. |
| PubMedID- 22562122 | Evidence regarding associations of obesity with breast cancer-specific survival (bcss) and overall survival (os) in relation to hormone receptor status, or bcss in relation to menopausal status has not been evaluated in a previous meta-analysis. |
| PubMedID- 23570924 | [development of overweight and obesity in breast cancer patients and its significance for diagnosis and clinical management: results of the basel breast cancer database 1990-2009]. |
| PubMedID- 26487401 | Multiple mechanisms are likely to account for the link between obesity and increased risk of postmenopausal breast cancer. |
| PubMedID- 20129610 | Accuracy of body mass index to determine obesity in women with breast cancer: an observational study of taiwanese sample. |
| PubMedID- 26359358 | Leptin, a major adipocytokine produced by adipocytes, is emerging as a key molecule linking obesity with breast cancer therefore, it is important to find effective strategies to antagonize oncogenic effects of leptin to disrupt obesity-cancer axis. |
| PubMedID- 24155680 | Recent studies have indicated an association of obesity with breast cancer progression. |
| PubMedID- 25793921 | obesity is associated with poor breast cancer (bc) prognosis. |
| PubMedID- 21311773 | Since experimental studies have demonstrated that adipocytes play a supportive role in breast growth [48], [49], [50], and as clinical studies have shown that obesity increases the incidence of breast cancer [1], [2], [3], we will analyse the role of cath-d up-regulation in obese adipocytes with regard to cancer. |
| PubMedID- 26286584 | More specifically, recent studies suggest that obesity increases the incidence of breast cancer [5, 6]. |
| PubMedID- 22121495 | A recent study has shown that fabp4 levels could be a novel and obesity-independent prognostic factor in patients with breast cancer [86]. |
| PubMedID- 25125682 | obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (cox-2) expression and activity in adipose-infiltrating macrophages. |
| PubMedID- 23374911 | obesity is increasingly associated with postmenopausal breast cancer risk [34], whereas, in premenopausal women there is an inverse relation between bmi and breast cancer risk [35,36]. |
| PubMedID- 24292402 | Purpose: obesity increases the risk of all-cause and breast cancer mortality. |
| PubMedID- 26552431 | The inverse association between obesity and risk of premenopausal breast cancer is less well understood mechanistically. |
| PubMedID- 24834284 | Mediators such as cytokine-like proteins, adipokines, particularly leptin and adiponectin, have been indentified to be obesity with breast cancer related factors (31). |
| PubMedID- 22800711 | Whereas obesity is positively associated with breast cancer risk after menopause, it is inversely associated with risk before menopause [21,22]. |
| PubMedID- 22992276 | Decreasing parity and increasing obesity are determinants of increasing breast cancer incidence among iranian women. |
| PubMedID- 24218051 | obesity is associated with basal-like breast cancer (bbc), an aggressive breast cancer subtype. |
| PubMedID- 22186408 | obesity is frequently associated with breast cancer. |
| PubMedID- 25866757 | Together, these data demonstrate a link between ovarian sex steroids, obesity, and inflammation with postmenopausal breast cancer. |
| PubMedID- 20941806 | Thus, hyperinsulinaemia may be one of the factors in the increased breast cancer risk seen with obesity and type 2 diabetes. |
| PubMedID- 22826466 | Clinical correlation studies have clearly shown that obesity is associated with breast cancer risk and patient survival. |
| PubMedID- 26182172 | Conclusions and relevance: obesity is associated with increased invasive breast cancer risk in postmenopausal women. |
| PubMedID- 21305540 | obesity is associated with breast cancer in african-american women but not hispanic women in south los angeles. |
| PubMedID- 23041473 | Although the underlying mechanisms are not clearly defined, aromatase is thought to play a pivotal role in connecting obesity-associated inflammation with postmenopausal breast cancer. |
| PubMedID- 26335225 | A high-fat, high calorie diet and sedentary lifestyle in some asian countries also contributed to the rising incidence of obesity, which is associated with breast cancer [33, 34]. |
| PubMedID- 24693452 | Most studies report that obesity is correlated with breast cancer in postmenopausal women; however, study from population-based sample of 1,360 australian women with breast cancer indicated that obesity is independently associated with poorer outcomes in premenopausal women, as it is in postmenopausal women [48]. |
| PubMedID- 23497298 | In this study, the major findings were as follows 1) bmi, an index of obesity, was significantly associated with female breast cancer. |
| PubMedID- 23346172 | The purpose of this study was to evaluate the predictive or prognostic value of obesity in breast cancer receiving neoadjuvant chemotherapy. |
| PubMedID- 23833528 | A single-stop approach, especially in high risk women (obesity, diabetes, family history of endometrial, ovarian or breast cancer) as well as in women with endometrial hyperplasia of combining the office hysteroscopy, directed biopsy in presence of a focal lesion, and vacuum sampling of endometrium in normal looking endometrium, all without anesthesia is the most minimally invasive and yet accurate approach in current practice. |
| PubMedID- 19898898 | Background: obesity is associated with poorer breast cancer-specific survival. |
| PubMedID- 24665149 | Observed that these two factors separately or in combination influence the body weight and obesity increases the risk of breast cancer in post-menopausal women.7 dumitrescu and cotarla supported this observation in their paper and noted that breast cancer risk is particularly evident among obese women who do not use hormone replacement therapy (hrt), and for each 5 kg of weight gain, breast cancer risk increases by 8%.1 this is explained by the fact that fat in adipose tissue is an important source of oestrogens, which are synthesised from cholesterol. |
| PubMedID- 20670865 | Background: obesity is strongly associated with endometrial and breast cancers; further, obese women are less likely to undergo recommended cancer screening. |
| PubMedID- 21194473 | The one unexpected observation was that obesity was not associated with breast cancer risk in women aged 55 years and older (or = 0.96, 95% ci 0.88 to 1.04). |
| PubMedID- 21198265 | Results: there was an increased risk of breast cancer associated with overweight or obesity in adulthood in chinese women. |
| PubMedID- 23835331 | Therefore, this animal model has allowed us to determine the effects of hyperinsulinemia in isolation from many of the other factors reported to contribute to breast cancer growth with obesity, t2d, and the mets (10). |
| PubMedID- 21750966 | obesity in breast cancer patients appears to impact the gene expression patterns of the tumor (perhaps as a result of altered body chemistry). |
| PubMedID- 22328885 | This observation has been confirmed in a recent prospective study which demonstrated that insulin resistance and obesity significantly influence risk of breast cancer development and progression [15]. |
| PubMedID- 23764995 | Environmental exposures, namely parity and obesity modified the effect of both snps on breast cancer risk in ea. |
| PubMedID- 24392267 | It confirmed that obesity at diagnosis of early-stage breast cancer is an independent prognostic factor for the development of distant metastases and death after the diagnosis of breast cancer [37]. |
| PubMedID- 24512931 | Background: obesity has been associated with breast cancer risk in the caucasian population but the association remains unclear in the hispanics. |
| PubMedID- 24829560 | The obesity-associated increased risk of post-menopausal breast cancer might be explained by higher rates of peripheral conversion of androgenic precursors to estradiol due to an increased aromatase enzyme activity in adipose tissue (48). |