PedAM
Pediatric Disease Annotations & Medicines
| Disease | thalassemia |
| Phenotype | |iron overload |
| Sentences | 80 |
| PubMedID- 24919862 | Based primarily on the findings of the thalassa (assessment of exjade((r)) in non-transfusion-dependent thalassemia) trial, the approval for deferasirox has recently been expanded to include the management of chronic iron overload in patients with non-transfusion-dependent thalassaemia (ntdt) syndromes. |
| PubMedID- 25988550 | Background: mri imaging is an alternative to serum ferritin for assessing iron overload in patients with thalassaemia disease. |
| PubMedID- 24087894 | Objective: we aimed to investigate the effect of human hemochromatosis protein (hfe) polymorphisms on cardiac iron overload in patients with beta-thalassemia major. |
| PubMedID- 25197009 | iron overload in beta-thalassemia major (tm) typically results in iron-induced cardiomyopathy, liver disease, and endocrine complications. |
| PubMedID- 24460526 | Myocardial iron overload in thalassaemia major. |
| PubMedID- 25745550 | This comes in harmony with the results of a previous study that was carried out by cheung et al,28 who found that iron overloading in patients with beta-thalassemia major results in alterations of arterial structures with disruption of elastic tissue and calcification. |
| PubMedID- 23830536 | Amlodipine reduces cardiac iron overload in patients with thalassemia major: a pilot trial. |
| PubMedID- 23019522 | Moreover, a review article that addresses the mechanism of tissue damage arising from iron overload in patients with β-thalassemia major is presented. |
| PubMedID- 23966105 | Authors' conclusions: in the absence of data from randomised controlled trials, there is no evidence to suggest the need for a change in current treatment recommendations; namely that deferiprone is indicated for treating iron overload in people with thalassaemia major when desferrioxamine is contraindicated or inadequate. |
| PubMedID- 22645668 | A study done on status of thyroid function and iron overload in patients with beta thalassemia major on deferoxamine in jordan concluded that there is significantly high (p < 0.05) levels of serum ferritin, ft3, zinc, and copper in patients with beta thalassemia major as compared to controls [13]. |
| PubMedID- 20950401 | Abnormal iron regulation in patients with thalassaemia intermedia may lead to iron overload even in the absence of transfusions. |
| PubMedID- 20383704 | Augmentation of left atrial contractile function: a herald of iron overload in patients with beta thalassemia major. |
| PubMedID- 25922644 | Hepatic iron overload and fibrosis in patients with beta thalassemia major after hematopoietic stem cell transplantation: a pilot study. |
| PubMedID- 23056717 | Objective: dilated cardiomyopathy is the end result of chronic iron overload in patients with beta thalassemia major. |
| PubMedID- 20027547 | Dual-echo tfe mri for the assessment of myocardial iron overload in beta-thalassemia major patients. |
| PubMedID- 21071497 | Continued improvement in myocardial t2* over two years of deferasirox therapy in beta-thalassemia major patients with cardiac iron overload. |
| PubMedID- 21757620 | Reproductive capacity in iron overloaded women with thalassemia major. |
| PubMedID- 22287873 | Cardiac toxicity includes congestive heart failure and arrhythmias and is the leading cause of death related to iron overload in patients with thalassemia major.13 excess iron deposition in the liver leads to inflammation, fibrosis, and cirrhosis,14 which may be further exacerbated by concomitant viral hepatitis, alcohol use, and other hepatotoxins. |
| PubMedID- 21752315 | Objective: to study the effectiveness and safety of deferasirox (dfx) in the treatment of iron overload in children with beta-thalassemia major. |
| PubMedID- 23241074 | Conclusion: we conclude that the use of dfx instead of dfo represents a cost-effective use of resources for treatment of iron overload in patients with beta-thalassemia from iran's society perspective. |
| PubMedID- 20813008 | Cardiac magnetic resonance (cmr) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major. |
| PubMedID- 22035015 | Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility. |
| PubMedID- 22391807 | The objective of this review is to discuss the factors which should be considered when designing clinically useful iron chelators, to present the application of iron chelators in the treatment of iron overload associated with beta-thalassaemia major and sickle cell anaemia, and to highlight the potential applications in the treatment of neurodegenerative disorders and microbial infection. |
| PubMedID- 25161967 | Background: diabetes mellitus is a major complication of iron overload in patients with beta thalassemia major. |
| PubMedID- 21897589 | thalassemia leads to variable pituitary iron overload and, thus, hypophyseal damage. |
| PubMedID- 20711357 | The importance of nutritional immunity as it pertains to iron is exemplified by the increased susceptibility to infection of individuals with iron overload due to thalassemia and primary hemochromatosis, two of the most common genetic diseases of humans [3]. |
| PubMedID- 19744128 | The aim of this study was to measure parathormone (pth) and metabolites of vitamin d and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major. |
| PubMedID- 24044606 | In thalassemia patients with iron overload, regular assessment of bone density from puberty every 2 years if normal, and annually if abnormal, might be required. |
| PubMedID- PMC3559304 | Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report has shown no evidence of cardiac iron in a small group (n=10) of multitransfused arab patients. |
| PubMedID- 23443782 | Objective: to assess the value of magnetic resonance imaging t2* tests in the detection of myocardial and liver iron overload in patients with beta-thalassemia major (beta-tm). |
| PubMedID- 26466432 | Impaired endothelial function in pediatric hemoglobin e/beta-thalassemia patients with iron overload. |
| PubMedID- 23056768 | Objective: hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. |
| PubMedID- 21075283 | iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies. |
| PubMedID- 20631898 | Despite iron overload in patients with β-thalassemia, hepcidin levels are not increased. |
| PubMedID- 22023452 | Although the evidence for the benefits of iron chelation therapy to treat iron overload in patients with thalassaemia is unequivocal and well founded, its use in patients with mds remains controversial because of a lack of definitive evidence documenting its benefits (10). |
| PubMedID- 25252297 | Assessment of the relationship between fragmented qrs and cardiac iron overload in patients with beta-thalassemia major. |
| PubMedID- 21382180 | The value of nontransferrin-bound iron (ntbi) as an index of iron overload in patients with thalassemia has been evaluated; however, data in patients with sickle cell disease (scd) is limited. |
| PubMedID- 24934354 | The hepatic iron overload in beta-thalassemia patients is associated with haemosiderin storage both in kupffer cells and in the cytoplasm of hepatocytes. |
| PubMedID- 23868464 | While dfx has been cited as a factor in a number of treatment-related deaths across several disease areas [48], no quantitative data were published on thalassaemia patients with transfusional iron overload, and so it was conservatively assumed that dfx was not associated with excess mortality. |
| PubMedID- 25402221 | The effects of deferasirox on renal haemodynamics, including glomerular filtration rate (gfr) and renal plasma flow (rpf), were investigated in a phase i, open-label study in beta thalassaemia major patients with iron overload. |
| PubMedID- 21791471 | This study evaluates whether iron overload in patients with beta thalassemia intermedia is associated with morbidity. |
| PubMedID- 20450494 | The pathophysiology of thalassaemia is associated with iron overload that generates oxygen free radicals and oxidative tissue injury with ocular vessel alterations. |
| PubMedID- 22052662 | Electrocardiographic consequences of cardiac iron overload in thalassemia major. |
| PubMedID- 22933160 | Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia. |
| PubMedID- 21452907 | Pharmacoeconomic considerations in treating iron overload in patients with beta-thalassaemia, sickle cell disease and myelodysplastic syndromes in the us: a literature review. |
| PubMedID- 22066516 | Relation between nt-probnp levels, iron overload, and early stage of myocardial dysfunction in beta-thalassemia major patients. |
| PubMedID- 20662901 | Conclusion: transfusional iron overload in patients with thalassaemia could be reduced to normal body iron range levels using effective deferiprone/deferoxamine combinations. |
| PubMedID- 24575259 | Background: frequent blood transfusion in patients with beta thalassemia major can lead to iron overload especially in liver. |
| PubMedID- 20001472 | Background: pituitary iron overload in patients with transfusion-dependent beta-thalassemia may lead to delayed puberty. |
| PubMedID- 23687960 | iron overload in beta-thalassaemia major patients is secondary to multiple blood transfusions and increased iron absorption. |
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