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PedAM

Pediatric Disease Annotations & Medicines




Disease pancreatic cancer
Phenotype |diabetes
Sentences 59
PubMedID- 22792091 pancreatic cancer patients with diabetes were predominantly females, while diabetes was equally prevalent among sexes in the control group.
PubMedID- 24254337 The us food and drug administration (fda) [35] and recent literature [36, 37] have highlighted controversies about the possible risks of pancreatitis and pancreatic cancer associated with some diabetes treatments.
PubMedID- 22960655 Methods: using microarray analysis, we identified adrenomedullin as a potential mediator of diabetes in patients with pancreatic cancer.
PubMedID- 25576058 Metformin treatment is associated with a decreased risk and better prognosis of pancreatic cancer (pc) in patients with type 2 diabetes, but the mechanism of metformin's pc growth inhibition in the context of a prediabetic state is unknown.
PubMedID- 25061491 The occurrence of pancreatic cancer is associated with diabetes and impaired glucose metabolism.
PubMedID- 21416856 [pancreatic cancer--association with diabetes mellitus and smoking].
PubMedID- 25673969 In the follow-up study, in which we assessed biomarkers in pancreatic cancer patients with diabetes after surgical resection, we found that the intensities of m/z at 1,465, 1,206, and 1,020 became comparable with those of diabetes-only patients.
PubMedID- 21416850 [pancreatic cancer--association with diabetes mellitus and smoking].
PubMedID- 24708788 As shown in figure 5, the serum levels of mif in the following five group patients were examined: pancreatic cancer patients without diabetes, pancreatic patients with more than two years history of diabetes, pancreatic patients with less than two years history of diabetes (new-onset diabetes), healthy subjects with normal fasting glucose, and t2dm patients (without any other immune diseases or tumor) diagnosed within in two years.
PubMedID- 22520674 Risk factors examined included: age, body mass index, smoking status, alcohol, deprivation, diabetes, pancreatitis, previous diagnosis of cancer apart from pancreatic cancer, dysphagia, abdominal pain, abdominal distension, appetite loss, weight loss, diarrhoea, constipation, tiredness, itching, and anaemia.
PubMedID- 24748867 It is possible that new-onset diabetes associated with pancreatic cancer is due to a combination of beta cell dysfunction and an increased insulin resistance [1, 3].
PubMedID- 23401773 One hundred and twenty-six sera form pancreatic cancer patients (84 with diabetes) were examined by seldi-tof in comparison to 61 sera from chronic pancreatitis (32 with diabetes), 24 from type 2 diabetes mellitus patients, and 12 from healthy controls.
PubMedID- 22982797 pancreatic cancer patients with coexisting diabetes had better overall survival than pancreatic cancer patients without diabetes (hazard ratio, 0.60; 95% confidence interval 0.44 to 0.80; p<0.001).
PubMedID- 25556126 As pancreatic cancer induces diabetes in about 40% of patients,313233 we excluded retrospective and cross sectional studies to avoid reverse causality.
PubMedID- 21274445 diabetes mellitus was associated with greater pancreatic cancer incidence [5, 6], although there is limited data supporting the theory that sugars or sweets are pathogenetically implicated [7].
PubMedID- 25877316 Objective: to investigate the changes of blood glucose in pancreatic cancer patients associated with diabetes mellitus (dm) after radiotherapy and analyze the related factors.
PubMedID- 25000673 Information on the clinical profile of pancreatic cancer (pc) associated with diabetes mellitus (dm) is limited.
PubMedID- 22920886 An additional study in americans analyzed a total of 1,172,496 case and control subjects and found that the frequency of pancreatic cancer in subjects with diabetes was 0.9% in comparison to subjects without diabetes (0.3%) [14].
PubMedID- 26273663 In literature, diabetes is associated with pancreatic cancer in 80% cases.
PubMedID- 24786605 In this prospective cohort-based study, we observed that participants who reported having diabetes before being diagnosed with pancreatic cancer had worse survival compared with those who did not have diabetes.
PubMedID- 22517654 Consistent with this possibility, epidemiological studies indicate that almost 1% of adults over age 50 with new-onset diabetes will be diagnosed with pancreatic cancer within 3 years (14).
PubMedID- 22015968 Objectives: type 2 diabetes is associated with increased pancreatic cancer risk; however, the nature of this relationship is not clear.
PubMedID- 20601806 Clinical outcome of pancreatic cancer patients with diabetes mellitus: is diabetes a poor prognostic factor.
PubMedID- 23667692 Recently, epidemiologic data revealed that metformin, but not other antidiabetic drugs, decreases the incidence of pancreatic cancer in patients with diabetes mellitus [8], [9].
PubMedID- 23669472 Conclusions: diabetes is associated with pancreatic cancer risk and this is similar across different duration categories.
PubMedID- 24574842 Several studies have found an increased incidence of pancreatic cancer in patients with diabetes mellitus (dm); however, other studies have shown that pancreatic cancer may cause glucose intolerance.
PubMedID- 22456038 With long-standing type 2 diabetes, the risk of pancreatic cancer is increased by up to 50% (30,31).
PubMedID- 23053420 This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a taiwanese population.
PubMedID- 23571023 Studies have revealed that pancreatic cancer (pc) may lead to diabetes mellitus (dm).
PubMedID- 24224094 Type 1 diabetes is associated with pancreatic cancer.
PubMedID- 25275365 We observed greater magnitude of hazard ratios (hrs) of pancreatic cancer for patients with type 2 diabetes along with acute alcoholic hepatitis, acute pancreatitis, cholecystitis, and gastric ulcer compared with patients without type 2 diabetes or counterpart comorbidity (hr: 1.36, 95% confidence interval (ci): 1.19-1.56; 1.74, 1.23-2.45; 9.18, 7.44-11.33; and 2.31, 1.98-2.70, respectively).
PubMedID- 26439801 Furthermore, the integrated optical density (iod) of sod2 and upa stainings is higher in the tumor tissues of pancreatic cancer patients with diabetes compared with pancreatic cancer patients with euglycemia.
PubMedID- 25856529 In addition, diabetes may be associated with pancreatic cancer risk or it may be an early indicator of disease [15–17].
PubMedID- 24136929 Genetic factors that modify the associations of obesity and diabetes with pancreatic cancer have previously not been examined at the genome-wide level.
PubMedID- 26391180 The limitations of the study are its retrospective design, the associated bias and the small number of samples in the study in pancreatic cancer patients with diabetes who underwent pancreatic cancer resection.
PubMedID- 21412116 Recent-onset diabetes associated with pancreatic cancer likely represents secondary or type 3 diabetes.
PubMedID- 23835106 The significant, positive association remained after excluding pancreatic cancer cases with recent-onset diabetes (or=1.92; 95%ci: 1.20–3.08).
PubMedID- 19844672 A possible underlying mechanism to account for an increased risk of pancreatic cancer in people with obesity and/or diabetes is chronically increased pancreatic duct cell replication.
PubMedID- 26074965 Similar survival benefits were seen in diabetes patients with pancreatic cancer on metformin [12].
PubMedID- 24454807 As bmi increased, mean age of the participants at baseline decreased, proportion of women increased, level of education displayed an inverse u-shaped curve, as did physical activity, diabetes was not associated with pancreatic cancer in the study, hr 1.384 (95% ci: 0.889–2.153).
PubMedID- 23393682 Damaged pancreatic tissue, secondary to pancreatic cancer, leads to diabetes as islet cells and beta cells are taken over by malignancy.
PubMedID- 25641178 In addition, the serum levels of opg were significantly higher in pancreatic cancer patients with new-onset diabetes than other groups including pancreatic patients without diabetes, new-onset type 2 diabetes and healthy controls.
PubMedID- 22750971 New-onset diabetes with a history of dyslipidemia predicts pancreatic cancer.
PubMedID- 22084685 diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases.
PubMedID- 24837144 Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
PubMedID- 22735942 Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age.
PubMedID- 23565475 [24] association of diabetes with pancreatic cancer is controversial with some studies, suggesting a two-fold increase in patients of diabetes of >5 years duration and others suggesting diabetes to be protective against pancreatic cancer.
PubMedID- 24058443 The risk factors considered were smoking, heavy alcohol intake, high bmi, diabetes, family history of pancreatic cancer, abo non-o blood group and three common genetic variants identified by gwas.
PubMedID- 25806358 Reports also indicate the association of diabetes with pancreatic cancer [33] hence it is important to address the problem and to evaluate the relationship between them.
PubMedID- 23400555 However, diabetes as a result of pancreatic cancer development is not infrequent, and chronic pancreatitis explains only less than 3% of pancreatic cancer cases.

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