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PedAM

Pediatric Disease Annotations & Medicines




Disease multiple sclerosis
Phenotype |encephalomyelitis
Sentences 56
PubMedID- 23437178 Here we demonstrate that the small tyrosine kinase inhibitor imatinib enhances bbb integrity in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (ms).
PubMedID- 25992667 Previously it was shown that swi detects hypointensities in the experimental autoimmune encephalomyelitis (eae) model of multiple sclerosis (ms), most of which are due to intravascular deoxyhemoglobin, with a small proportion being due to iron deposition in the central nervous system parenchyma and demyelination.
PubMedID- 25954276 Cell internalized socs1-kir is a potent therapeutic in the experimental allergic encephalomyelitis (eae) mouse model of multiple sclerosis and showed promise in a psoriasis model and a model of diabetes-associated cardiovascular disease.
PubMedID- 24244457 In addition to presumably microbial product-associated diseases such as experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis [74], the involvement of tlr4 has also been reported in apparently noninfectious disorders such as neuropathic pain caused by transection of the spinal nerves [75] and ischemic brain injury [76], [77].
PubMedID- 21387369 Recent findings in experimental autoimmune encephalomyelitis, an animal model of human multiple sclerosis, suggest that altering certain bacterial populations present in the gut can lead to a proinflammatory condition that may result in the development of autoimmune diseases, in particular human multiple sclerosis.
PubMedID- 22566901 Likewise, mast cells were found to accumulate in brain lesions in experimental allergic encephalomyelitis (eae), a model of multiple sclerosis induced by immunizing mice with myelin or myelin-derived peptides.
PubMedID- 24454481 The experimental autoimmune encephalomyelitis (eae) model of multiple sclerosis (ms) provided the first clues to the possibility that other t cell effector functions, beyond those attributed to the th1 and th2 subsets, could be contributing to the onset and progression of autoimmune disorders.
PubMedID- 22208359 In addition, irf3 is critical in neuroprotection mediated by lps preconditioning [22], as well as in limiting injury in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
PubMedID- 26173397 In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, the administration of β-lap ameliorates the development of eae by inhibiting the production of il-12 family cytokines [37].
PubMedID- 25959684 Here we studied the autoantibody specificity elicited by proteolipid protein (plp) in mp4-induced experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis (ms).
PubMedID- 26236190 Interestingly, in the relapse/remitting experimental autoimmune encephalomyelitis (eae) animal model of multiple sclerosis (ms), a condition of continuous inflammation, the same attenuated response was been observed (marques et al., 2012).
PubMedID- 22156784 This case demonstrates that stem cell transplantation may provoke life-threatening encephalomyelitis in patients with multiple sclerosis.
PubMedID- 20042183 Previously we have shown that dab(389)il-2, a recombinant fusion toxin targeting il-2r bearing cells, suppressed disease in the rat experimental autoimmune encephalomyelitis (eae) model of acute multiple sclerosis (ms).
PubMedID- 26111002 In a murine experimental autoimmune encephalomyelitis model of multiple sclerosis, this liposomal glucocorticoid was more efficient than a five times higher dose of non-liposomal glucocorticoid [179].
PubMedID- 26259611 However, in vivo cd300f has shown to be mainly an inhibitory receptor, as shown in cd300f knockout animals using the experimental autoimmune encephalomyelitis (eae) model of multiple sclerosis [39] and very recently in several models of allergy [40] and systemic lupus erythematosus [36].
PubMedID- 25938431 Using the experimental autoimmune encephalomyelitis model of human multiple sclerosis and an acute inflammation model, we found that the administration of viola reduced the inflammation through the down-modulation of inflammatory mediators in the central nervous system as well as the systemic release of inflammatory cytokines.
PubMedID- 25738751 In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type i interferons restrict disease severity.
PubMedID- 24416655 Further, the type i ifn mimetics provide therapeutic protection against experimental allergic encephalomyelitis (eae), a model of multiple sclerosis, without the side effects.
PubMedID- 24727948 In murine experimental autoimmune encephalomyelitis (eae), a model of multiple sclerosis, ephrem et al.
PubMedID- 25750613 In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, fasudil reduced inflammation and demyelination.
PubMedID- 21325623 Mast cells (mcs) exert a significant pathologic influence on disease severity in c57bl/6 (b6) strain-dependent experimental allergic encephalomyelitis (eae), a model of primary progressive multiple sclerosis (ms).
PubMedID- 22007171 The scn2b null mutation is neuroprotective in the experimental allergic encephalomyelitis mouse model of multiple sclerosis (o’malley et al., 2009).
PubMedID- 24244694 To demonstrate this methodology we have simulated the prototypic murine t cell-mediated autoimmune disease experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
PubMedID- 23506036 In addition, perivascular macrophages (which express cd163)have been reported to increase in numbers in eae (experimental autoimmune encephalomyelitis), ananimal model of multiple sclerosis (zhang et al., 2011), andappear to be required for regeneration of nerve grafts (dahlin, 1995) and in the recovery phase of eae (almolda et al., 2010).
PubMedID- 22161544 In an experimental allergic encephalomyelitis model of multiple sclerosis, rodents that received an intraventricular infusion of msc were found to have almost twice the number of axons as control animals [25].
PubMedID- 24744610 Haecs have been examined for the therapeutic effect in an eae (experimental autoimmune encephalomyelitis) mouse model of multiple sclerosis.32,70 mcdonald et al reported that intraperitoneal injection of haecs suppressed symptoms and decreased cns inflammation, demyelination, and axonal degeneration in the spinal cord and brain of a mouse model of multiple sclerosis.32 they also found that haecs reduced proliferation of t cells and decreased their secretion of proinflammatory cytokines.32 more recently liu et al reported that intravenously administered haecs reduced cd3+ t cell and f4/80(+) monocyte/macrophage infiltration and demyelination within the cns of an eae mouse.70 haecs immunosuppression was mediated by pge2 and tgf-β, as it was demonstrated by the neutralization of tgf-β or pge2 in splenocyte proliferation assays.
PubMedID- 23844272 When tested in an experimental autoimmune encephalomyelitis (eae) murine model of multiple sclerosis, 1 mg/kg oral diazoxide ameliorated eae clinical signs but did not prevent disease.
PubMedID- 24130809 Studies using c57bl/10 and c57bl/6 (cnr2tm1zim) cb2 cannabinoid receptor knockout mice have demonstrated an immune-augmenting effect in experimental autoimmune encephalomyelitis (eae) models of multiple sclerosis.
PubMedID- 24625696 Here we show that during experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, the expression of darc is upregulated at the blood–brain barrier.
PubMedID- 24376447 A third study providing additional evidence that pre-mnk cells play a protective role in autoimmune diseases exploited the murine experimental autoimmune encephalomyelitis (eae) model of multiple sclerosis (66).
PubMedID- 26579520 This neo-antigen causes disease in experimental autoimmune encephalomyelitis (the mouse model of multiple sclerosis) (zhou et al., 1995).
PubMedID- 23991103 Extracellular ph also falls during autoimmune encephalomyelitis, a mouse model of multiple sclerosis, and loss of asic1a in asic1a−/− mice was neuroprotective [41].
PubMedID- 22417924 Other pparγ antagonists are implicated in neurotoxicity, bisphenol a diglycidyl ether (badge) worsens clinical scores in the experimental allergic encephalomyelitis model of multiple sclerosis (raikwar et al., 2005).
PubMedID- 22094132 In experimental autoimmune encephalomyelitis (eae), a model of multiple sclerosis, epo inhibits pro-inflammatory responses of antigen-specific t cells and induces immune tolerance [35,36].
PubMedID- 24252604 We report that dab2 is up-regulated in lesional macrophages/microglia in the spinal cord in murine experimental autoimmune encephalomyelitis, a model of multiple sclerosis.
PubMedID- 21573157 Their epidemiology and aetiology remain poorly understood [10], [11], but experimental studies in mice suggest that infections with parasitic helminths such as schistosoma mansoni can protect against auto-immune diseases including experimental auto-immune encephalomyelitis, the experimental model of multiple sclerosis [12], graves hyperthyroidism [13], type 1 diabetes and experimental colitis [14], [15], [16].
PubMedID- 25879435 Experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, is a demyelinating disease of the cns that progressively results in escalating degrees of ascending paralysis with inflammation primarily targeting the spinal cord.
PubMedID- 22437532 Furthermore, mscs have been reported to ameliorate experimental murine autoimmune encephalomyelitis in a model of multiple sclerosis [28], prolong the survival of baboon skin in an allotransplation model [2], and control lethal graft vs. host complications [14].
PubMedID- 23613717 We chose experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, to induce chronic inflammation to the central nervous system (cns).
PubMedID- 23125525 Unexpectedly, in experimental autoimmune encephalomyelitis (eae, a model of multiple sclerosis), cd73-deficiency resulted in resistance to the disease [53].
PubMedID- 24107995 Here we show that among the most effective compounds identifed was benztropine, which significantly decreases clinical severity in the experimental autoimmune encephalomyelitis (eae) model of relapsing-remitting multiple sclerosis when administered alone or in combination with approved immunosuppressive treatments for multiple sclerosis.
PubMedID- 21886606 In vivo chronic lithium treatment also markedly suppressed eae (experimental autoimmune encephalomyelitis), an animal model of multiple sclerosis that involves substantial neuroinflammation, and the production of inflammatory th17 cells that contribute to eae pathogenesis (de sarno et al., 2008; beurel et al., 2011a).
PubMedID- 20504283 In the experimental autoimmune encephalomyelitis murine model of multiple sclerosis, mscs were shown to decrease the clinical signs associated with demyelinization when injected before or at the onset of the disease, demonstrating the therapeutic efficacy of mscs [34].
PubMedID- 24053384 We studied the immune response to the axonal protein neurofilament light (nf-l) in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.
PubMedID- 23175609 We recently reported that a single-stranded dna aptamer (ljm-3064) selected for affinity to crude murine myelin induces remyelination after intraperitoneal injection in the theiler’s murine encephalomyelitis virus (tmev) model of multiple sclerosis (1).
PubMedID- 23235422 We present clinical and laboratory differential diagnostic criteria of chronic borrelial encephalomyelitis in comparison with multiple sclerosis.
PubMedID- 25912039 Th1 and th17 cells cause experimental autoimmune encephalomyelitis (eae, murine model of multiple sclerosis), inflammatory bowel disease and type-1 diabetes.
PubMedID- 24456642 Fty720 also accumulates in the cns, and its administration in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, did not reduce disease symptoms in mice that lacked s1p1 expression in astrocytes, indicating that the drug acts directly on astrocytes to block neuroinflammation [31].
PubMedID- 22747898 Most prominently, atorvastatin application in experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis, leads to reduced disease severity due to effects on antigen presentation and t-cell activation and phenotype [3].
PubMedID- 26300850 Similarly, phage displaying an immunodominant peptide epitope derived from myelin oligodendrocyte glycoprotein depleted pathogenic demyelinating antibodies in brain tissue in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis (rakover et al., 2010).

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