PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Phenotype | |diabetes |
| Sentences | 65 |
| PubMedID- 24260287 | Obesity and diabetes are associated with increased breast cancer risk and worse disease progression once cancer is diagnosed; however, the exact etiology behind these observations remains to be fully elucidated. |
| PubMedID- 20077000 | In conclusion, type 2 diabetes is associated with poor breast cancer prognosis. |
| PubMedID- 23401790 | The combined evidence overall supported a modest association between type 2 diabetes and the risk of breast cancer, which was found to be more prevalent among postmenopausal women. |
| PubMedID- 26185535 | Most studies for the identification of risk factors for breast cancer among women with diabetes have concentrated on type 2 dm and have failed to discriminate between types 1 and 2. therefore, any correlations to type 1 dm remain dubious 15. we conducted a general female population-based cohort study to assess the implications of type1/2 diabetes mellitus in breast cancer development. |
| PubMedID- 25866823 | In the taiwan study, breast cancer patients with diabetes had a significantly increased mortality with a hazard ratio (hr) of 1.57 (95% ci: 1.15–2.15) [118]. |
| PubMedID- 23244125 | Objective: the aim was to investigate indicators related to dna damage and cancer pathogenesis in type ii diabetes cases with breast cancer. |
| PubMedID- 26171401 | Studies also suggested a higher risk of breast cancer in women with prediabetes [23] and type 2 diabetes [24], both are characterized by endogenous hyperinsulinemia resulting from insulin resistance. |
| PubMedID- 22996614 | The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. |
| PubMedID- 21972408 | Previous epidemiologic research suggests a modestly elevated risk of breast cancer in women with type 2 diabetes (t2d), particularly after menopause (1). |
| PubMedID- 22296353 | Methods: 105 breast cancer patients with type-2 diabetes mellitus (dm) presenting from january 2005 to december 2010 were enrolled in this study. |
| PubMedID- 23138438 | Recent findings: in the past year, studies have shifted focus from effects on cardiovascular disease and diabetes to effects of mets on breast cancer as well as menopausal symptoms. |
| PubMedID- 25679392 | Whether the increased mortality risk among breast cancer survivors with diabetes is driven by an increase in cancer recurrence or a result of competing diabetes-related comorbidities such as cardiovascular disease remains unclear. |
| PubMedID- 24281091 | Currently, the comorbidity and interaction of diabetes with breast cancer is arousing great research interest. |
| PubMedID- 25866793 | A study by currie and colleagues showed that mortality increased in elderly breast cancer patients with diabetes, and metformin treatment improved survival rates in comparison with other diabetic treatments (sulfonylureas and insulin) and compared to a nondiabetic patient cohort [29]. |
| PubMedID- 26537234 | Mammalian target of rapamycin (mtor) is activated by insulin and insulin-mediated breast cancer progression in patients with type 2 diabetes mellitus may be abrogated by inhibition of mtor [5]. |
| PubMedID- 22261802 | This will largely draw the attention of hdl-based treatments in the diabetes patients with breast cancer. |
| PubMedID- 24349656 | Pre-existing diabetes increased the risk of breast cancer significantly only in the post-menopause group (or, 1.44; 95% ci, 1.03 to 2.01), whereas it showed no significant association in the pre-menopause group. |
| PubMedID- 21632448 | diabetes is associated with postmenopausal breast cancer, too, with summary rrs from meta-analyses of 1.15-1.20, but not with premenopausal breast cancer (rr, 0.9). |
| PubMedID- 25723884 | Dexrazoxane protects breast cancer patients with diabetes from chemotherapy-induced cardiotoxicity. |
| PubMedID- 25779100 | diabetes was associated with more advanced-stage breast cancer, even after accounting for differences in screening mammogram use and other factors. |
| PubMedID- 23292119 | In total, the study included 1,013 breast cancer patients with diabetes and 4,621 breast cancer patients without diabetes. |
| PubMedID- 23259613 | Our objectives were to identify factors associated with previously undiagnosed diabetes in breast cancer, and to examine associations between previously undiagnosed diabetes and cancer stage, treatment patterns, and mortality. |
| PubMedID- 23826297 | However, the increased risk of breast cancer associated with diabetes (i.e., 42%) noted in our study was comparable with those of previous studies [1]–[3], [8]. |
| PubMedID- 23949559 | Conclusions this international study found no difference in the risk of developing breast cancer in patients with diabetes among the different types of insulin with short- to mid-term duration of use. |
| PubMedID- 22848683 | Increased risk of breast cancer has been associated with diabetes in numerous epidemiological studies [27], therefore we also studied the effect of insulin analogues on the production of pip3 in breast cancer derived cell lines using a new, highly sensitive bret-based assay. |
| PubMedID- 23829168 | Both cohort and case–control epidemiological observations have demonstrated the association of metabolic syndrome, obesity and diabetes with increased breast cancer risk [5,6]. |
| PubMedID- 23882052 | (30) have recently published a detailed meta-analysis of breast cancer in diabetes, concluding that there may be a 27% increase in type 2 diabetes but not in type 1 diabetes or gestational diabetes mellitus where insulin use is universal or more common. |
| PubMedID- 21115861 | Purpose: self-reported diabetes has been associated with poor breast cancer outcomes. |
| PubMedID- 25107658 | Studies have shown an increased risk of breast cancer associated with diabetes which may be due to differences in mammography use among women who have diabetes compared with women who do not have diabetes. |
| PubMedID- 20490716 | The coexistence of type 2 diabetes with breast cancer may result in poorer cancer-related survival due to a number of mediating factors including an alteration of tumor tissue hormonal sensitivity. |
| PubMedID- 24564865 | For example, thioethershave therapeutic potential for treatment of hiv,1 breast cancer,2 inflammatorydiseases,3,4 diabetes,5 andalzheimer’s disease.6 despite theirabundance, until recently few general methods were available for theirsynthesis under mild conditions that would tolerate sensitive heterocycles.in this manuscript, we report synthesis of diaryl sulfides by in situformation of highly reactive sulfenyl chlorides and subsequent trappingwith arylzinc reagents. |
| PubMedID- 25877238 | Objective: to explore the expression of hypoxia-inducible factor 1 alpha (hif-1alpha) in tissue of breast cancer complicated with diabetes and examine the correlation with vascular endothelial growth factor (vegf) and microvascular density (mvd). |
| PubMedID- 24834121 | In a second study, dr fontanella and colleagues investigated the incidence of type 2 diabetes in patients with early breast cancer at the time of diagnosis, as well as its effect on the outcome after neoadjuvant chemotherapy. |
| PubMedID- 26171112 | Epidemiological findings indicate a close relationship between diabetes and many types of cancer (including breast cancer risk), which regards not only the dysmetabolic condition, but also its underlying risk factors and therapeutic interventions. |
| PubMedID- 24869799 | Higher body mass index (bmi) and diabetes are associated with worse breast cancer prognosis. |
| PubMedID- 23238788 | Methods: we used population-based data from ontario, canada to compare the incidence of diabetes among women with breast cancer, aged 55 years or older, from 1996 to 2008, with that of age-matched women without breast cancer. |
| PubMedID- 25971328 | diabetes mellitus is associated with breast cancer: systematic review, meta-analysis, and in silico reproduction. |
| PubMedID- 26446233 | Results: a total of 11 studies consisting of 5,464 breast cancer patients with diabetes were included, comprising 2,760 patients who had received metformin and 2,704 patients who had not. |
| PubMedID- 21614572 | Conclusions/interpretation: the risk of breast cancer in women with type 2 diabetes is not increased during the first 5 years of insulin glargine use. |
| PubMedID- 24096546 | The subjects included 680 breast cancer patients with diabetes and 5,105 breast cancer patients without diabetes. |
| PubMedID- 24937172 | Background and aims: although underlying mechanisms have been described to account for the association between prediabetes and diabetes with breast cancer, reported results have been inconsistent. |
| PubMedID- 25261292 | Thus, the continuum of care for breast cancer patients with diabetes should include careful attention to cvd risk factors and other non-cancer conditions. |
| PubMedID- 24587242 | Moreover, it has been reported that there are difference between the breast cancer patients with diabetes and their nondiabetic counterparts in the regimen choice and effects of breast cancer treatment [1], [2], [4]. |
| PubMedID- 25854171 | The objective of this study was to investigate the clinical pathological characteristics of breast cancer (bc) patients with secondary diabetes after systemic therapy without preexisting diabetes. |
| PubMedID- 24899083 | We examined whether receipt of guideline-concordant breast cancer treatment varied with diabetes severity. |
| PubMedID- 20625814 | Relationship between diabetes and risk of second primary contralateral breast cancer. |
| PubMedID- 21357383 | No association of risk variants for diabetes and obesity with breast cancer: the multiethnic cohort and page studies. |
| PubMedID- 24026538 | Conclusion: when taking competing mortality into account, rfp was better in elderly breast cancer patients with diabetes compared with patients without diabetes. |
| PubMedID- 26148588 | Aim: we tend to explore the expression characteristics of proteins in igf/ir axis in breast cancer with type 2 diabetes mellitus (t2dm). |
| PubMedID- 26472977 | We searched the pubmed and embase databases (from inception to february 10, 2015) for randomized and observational studies that discussed the association between metformin and breast cancer in patients with diabetes mellitus, by using the following search terms: "metformin" and "breast cancer." |
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