PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Symptom | C0856169|endothelial dysfunction |
| Sentences | 96 |
| PubMedID- 19929443 | These findings suggest that cse-induced oxidative/nitrosative stress impairs vegf- and fss-mediated endothelial cell function and has important implications in the pathogenesis of cs-induced pulmonary and cardiovascular diseases associated with endothelial dysfunction. |
| PubMedID- 23199039 | If a correlation is established using accessible methodologies, the opportunity exists for epcs to be used routinely as an index of endothelial dysfunction associated with vascular diseases. |
| PubMedID- 20051879 | Given the well-documented association of endothelial dysfunction with cardiovascular disease and risk, this activity of torcetrapib may have contributed to increased cardiovascular risk in clinical trials. |
| PubMedID- 26499181 | Dysfunction in the production and/or the bioavailability of no characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis. |
| PubMedID- 20051854 | Recent findings: recent studies demonstrate that circulating levels of microparticles originating from endothelial cells, which represent a small fraction of the overall pool of plasma microparticles, augment with increased endothelial dysfunction in patients with cardiovascular diseases. |
| PubMedID- 24260221 | Increased plasma levels of adma are associated with endothelial dysfunction in patients with vascular disease or risk factors 1. |
| PubMedID- 21884717 | Puerarin may be useful for the treatment or prevention of endothelial dysfunction associated with diabetes and cardiovascular disease. |
| PubMedID- 20560781 | Therefore, sk and ik channels may be drug targets for the treatment of endothelial dysfunction in cardiovascular disease. |
| PubMedID- 24330769 | Peripheral vascular disease leads to endothelial dysfunction, which is associated with renal insufficiency and contributes to cardiovascular mortality . |
| PubMedID- 21179100 | Chronic inflammation and endothelial dysfunction may be associated with hypertension and cardiovascular disease. |
| PubMedID- 23288200 | In addition, blockade of ca influx by beo and la in ea cells may explain the protective effects of beo on endothelial dysfunction associated with cardiovascular disease. |
| PubMedID- 21516134 | Increased homocysteine, uric acid, glucose, and ox-ldl levels represent risk factors for cardiovascular diseases associated with endothelial dysfunction. |
| PubMedID- 20668652 | Indeed, oxidative stress has been clearly implicated in vascular remodeling and endothelial dysfunction associated with cerebrovascular diseases , raising the possibility that it might represent an additive event involved in ccm pathogenesis. |
| PubMedID- 25201890 | These results suggest that endothelial vdr plays an important role in endothelial cell function and blood pressure control and imply a potential role for vdr agonists in the management of cardiovascular disease associated with endothelial dysfunction. |
| PubMedID- 21283658 | vascular disease associated with endothelial dysfunction includes type-2 diabetes and hypertension (for review 6) linked to obesity. |
| PubMedID- 20164784 | The progression of insulin resistance to diabetes mellitus parallels the progression of endothelial dysfunction to atherosclerosis leading to cardiovascular disease and its complications. |
| PubMedID- 22151409 | Background: cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (mmvd) might also have endothelial dysfunction. |
| PubMedID- 24087956 | In young men with g1ah risk factors for endothelial dysfunction were: family history of early cardiovascular disease, smoking, and elevation of low-density cholesterol level. |
| PubMedID- 22899172 | Therefore, having regard to its ability to bind to ers, apigenin may be considered an oestrogen-like molecule to potentially be used against the onset and progression of vascular diseases associated with endothelial dysfunction. |
| PubMedID- 23427281 | The use of er activators, such as apigenin, may represent a strategy to prevent vascular disease associated with endothelial dysfunction, while avoiding the feminizing effects of estrogens. |
| PubMedID- 24215873 | Objective: to explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease (cvd). |
| PubMedID- 22383985 | endothelial dysfunction associates with hypertension and vascular disease in the presence of chronic kidney disease but the mechanisms that regulate the activation of the endothelium at the early stages of the disease, before systemic inflammation is established remain obscure. |
| PubMedID- 24707472 | Reduced vasodilator capacity—endothelial dysfunction—has been associated with cardiovascular disease, in particular atherosclerosis 2. |
| PubMedID- 21737782 | Conclusions: these findings suggest that cumulative cardiovascular risk may enhance rock activity and endothelial dysfunction, leading to progression of cardiovascular diseases and outcomes. |
| PubMedID- 21515242 | Hyperhomocysteinemia (hhcy), a risk factor for cardiovascular disease, is associated with endothelial dysfunction. |
| PubMedID- 26339184 | High vwf:ag and vwfpp levels were reported in vascular diseases associated with endothelial dysfunction.4–7,10 vwf:ag has been listed as one of the hemostatic biomarkers although it is not widely used in clinical practice. |
| PubMedID- 23696766 | Vitamin c has recently been found to protect endothelial cells and ldl from intra- and extracellular oxidative stress6 and to reduce the risk of atherosclerosis.7 in addition, folic acid can lower plasma homocysteine concentrations and to revert endothelial dysfunction in patients with cardiovascular diseases.8 potassium, on the other hand, may contribute to lower blood pressure.6-9 four-week consumption of orange juice in healthy middle-aged, normal-weight men has been suggested to reduce diastolic blood pressure (dbp). |
| PubMedID- 24763109 | Importantly, endothelial senescence is associated with endothelial dysfunction and pathology of vascular disease, including hypertension and atherosclerosis 3. |
| PubMedID- 20888896 | Notably, vascular aging and cardiovascular disease are both associated with endothelial dysfunction, or a marked decrease in production and bioavailability the vasodilator of nitric oxide (no). |
| PubMedID- 25387998 | Our analyses are not only limited to the importance of endothelial dysfunction in cardiovascular disease progression, but also expand into the molecular mechanisms and pathways underlying the inhibition of endothelial dysfunction by anti-inflammatory/immunosuppressive cytokines. |
| PubMedID- 25949771 | Oxidative stress is considered to be the primary cause of many cardiovascular diseases, including endothelial dysfunction in atherosclerosis and ischemic heart disease, hypertension, and heart failure. |
| PubMedID- 20145343 | Diagnosis and treatment of endothelial dysfunction in cardiovascular disease. |
| PubMedID- 26425704 | Here, we investigated associations among telomere g-tail length in leukocytes, aging, vascular risk factors and endothelial dysfunction in patients with chronic cerebrovascular disease and comorbidities. |
| PubMedID- 24092446 | Aims: changes in circulating brain-derived neurotrophic factor (bdnf) levels were reported in patients with or at risk for cardiovascular diseases associated with endothelial dysfunction, suggesting a link between bdnf and endothelial functionality. |
| PubMedID- 23936957 | Besides numerous modifiable and non-modifiable known risk factors, microalbuminuria is thought to be an important marker of global endothelial dysfunction and associated with cardiovascular disease including stroke. |
| PubMedID- 24772374 | They suggest a vicious cycle between autonomic dysfunction and endothelial dysfunction leading to cardiovascular disease, which can be prevented by exercise . |
| PubMedID- 23057846 | It has been demonstrated that mtros contribute to the oxidative stress and endothelial dysfunction characteristic of cvd (cardiovascular disease) . |
| PubMedID- 24843412 | Insulin resistance in vascular tissues is associated with endothelial dysfunction, leading to cardiovascular diseases including atherosclerosis127. |
| PubMedID- 24665093 | Age-related arterial endothelial dysfunction, a key antecedent of the development of cardiovascular disease (cvd), is largely caused by a reduction in nitric oxide (no) bioavailability as a consequence of oxidative stress. |
| PubMedID- 23525410 | Blood was taken from the cubital veins of healthy human volunteers and cardiovascular disease (cvd) patients with documented endothelial dysfunction (table 1). |
| PubMedID- 22642467 | Arterial stiffening may be a mechanism through which inflammation and (or) endothelial dysfunction lead to cardiovascular disease. |
| PubMedID- 23417760 | endothelial dysfunction associated with diabetes and cardiovascular disease is characterized by changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function. |
| PubMedID- 24617305 | Pleiotropic beneficial effects of epigallocatechin gallate, quercetin and delphinidin on cardiovascular diseases associated with endothelial dysfunction. |
| PubMedID- 19195861 | Diabetes mellitus is associated with increased endothelial dysfunction and development of atherosclerotic vascular diseases. |
| PubMedID- 21150342 | Increased macrovascular disease is strongly associated with redox stress, endothelial dysfunction, atherogenic-diabetic dyslipidemia (increased small low density lipoprotein particles, decreased high density lipoproteins and elevated triglycerides and free fatty acids), hypertension, hypercoagulability (impaired fibrinolysis and platelet hyperaggregability), autonomic neuropathy and eventual glucotoxicity. |
| PubMedID- 22343535 | Arterial stiffening may be a mechanism through which low-grade inflammation and (or) endothelial dysfunction lead to cardiovascular disease. |
| PubMedID- 20858217 | Oxidative stress and endothelial dysfunction in cardiovascular disease: mitochondria-targeted therapeutics. |
| PubMedID- 25096223 | These findings suggest that hdac5, a binding partner and modulator of klf2, could be a new therapeutic target to prevent vascular endothelial dysfunction associated with cardiovascular diseases. |
| PubMedID- 21789188 | The recent discovery of sgc stimulators including riociguat (bay 63-2521) offers an attractive option for the management of cardiovascular disease associated with underlying endothelial dysfunction. |
| PubMedID- 20886881 | Oxidative stress and vascular inflammatory response are key mediators of endothelial dysfunction that leads to cardiovascular diseases. |
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