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PedAM

Pediatric Disease Annotations & Medicines




Disease thrombocytopenia
Symptom C0002878|hemolytic anemia
Sentences 30
PubMedID- 21151638 8 reported a case of thrombocytopenia associated with hemolytic anemia in a patient with intracardiac metastasis originating from a testicular teratoma.
PubMedID- 26576277 The combination of severe anemia, acute kidney injury, and indeterminate platelet count suggested a preliminary differential diagnosis of a thrombotic microangiopathy, autoimmune hemolytic anemia with immune thrombocytopenia, or disseminated intravascular coagulation (dic) secondary to sepsis.
PubMedID- 23989401 For thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (ttp-hus) the diagnosis of coombs negative hemolytic anemia together with thrombocytopenia should lead to the detection of fragmentocytes in peripheral blood smears.
PubMedID- 20399168 hemolytic anemia with schistocytes, thrombocytopenia without evidence of disseminated intravascular coagulation, and renal failure are consistently found.
PubMedID- 20359326 This disease causes hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and nonfocal neurologic findings, and decreased renal function.
PubMedID- 21772952 Evans syndrome (es) is an autoimmune disorder characterized by thrombocytopenia and/or neutropenia associated with hemolytic anemia (aha).1–3 it is a potentially life-threatening condition that may be associated with other underlying autoimmune or lymph-proliferative disorders.4 standard treatment consists of transfusions, corticosteroids and immunoglobulins (ivig); second-line treatment in es evolved over the last decade, and includes at present anti-cd20 rituximab, vincristine, alkalizing agents, mycophenolate mofetil (mmf) or cyclosporine (cya).5–6,8–14 long-term remissions induced by splenectomy are less frequent than in uncomplicated immune thrombocytopenia purpura (itp).
PubMedID- 22567489 A peripheral smear showed thrombocytopenia with low-grade microangiopathic hemolytic anemia (maha).
PubMedID- 21961487 He was diagnosed to have es at the age of 8, during another bout of thrombocytopenia, this time associated with coombs-positive hemolytic anemia.
PubMedID- 21776377 Laboratory findings revealed thrombocytopenia with hemolytic anemia.
PubMedID- 26082779 Ahus is characterized by a triad of hemolytic anemia due to fragmented erythrocytes, thrombocytopenia, and acute renal failure.
PubMedID- 23602056 thrombocytopenia together with microangiopathic hemolytic anemia is mandatory for the diagnosis of ttp and if these two criteria met in a patient, tpe should be performed immediately.
PubMedID- 21151550 Peripheral blood smear examination revealed schistocytes and thrombocytopenia consistent with microangiopathic hemolytic anemia (fig.
PubMedID- 23772412 The lowest platelet count occurred at postoperative day 9. to identify the reason for the refractory response to platelet transfusion, a study for antibody to platelet and additional immune workup were performed on postoperative days 9 and 10. the findings included hemolytic anemia with thrombocytopenia (hemoglobin=7.6 g/dl, platelet=15,000/µl, schistocytosis(+) in a peripheral blood smear), negative direct and indirect coombs tests, decreased haptoglobin (3 mg/dl), normal ranges of an international normalized ratio (inr 1.13), activated partial thromboplastin time (38.2 seconds) and fibrinogen (287 mg/dl), slightly elevated d-dimer (3.3 µg/ml), hyperbilirubinemia (total bilirubin 3.28 mg/dl, direct bilirubin 1.9 mg/dl), increased lactate dehydrogenase (580 mg/dl), normal serum alanine aminotransferase (10 iu/l) and aspartate aminotransferase (15 iu/l), increased blood urea nitrogen (51 mg/dl), normal creatinine (0.8 mg/dl), microscopic hematuria (red blood cell >30/hpf), negative human immunodeficiency virus antibody, and positive hepatitis b surface antibody.
PubMedID- 24013519 A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder.
PubMedID- 21559455 The criteria for hus diagnosis were microangiopathic hemolytic anemia with schizocytes, thrombocytopenia (platelet count <150×109/l) and acute renal failure (serum creatinine level higher than the normal values considering the age of the patient).
PubMedID- 25821808 Eryptosis is triggered by hemolytic uremic syndrome (hus), characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute renal failure .
PubMedID- 20331741 Recognition of cancer-associated microangiopathic hemolytic anemia with thrombocytopenia (ca-mha) is paramount to avoid inappropriate pe therapy and delays in cancer-specific chemotherapy.
PubMedID- 23304632 The traditional diagnostic criteria for this syndrome include hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and renal failure 1.
PubMedID- 23758712 Hemangioma-thrombocytopenia syndrome associated with microangiopathic hemolytic anemia has been documented in children.
PubMedID- 20636987 Objective: to identify and characterize the syndrome of immune-mediated hemolytic anemia (imha) with concurrent severe thrombocytopenia (
PubMedID- 20436664 Thrombotic microangiopathies (tma) represent a rare and heterogeneous group of diseases defined by microangiopathic hemolytic anemia with peripheral thrombocytopenia and organ failure of variable severity.
PubMedID- 24490094 There are many reported cases of hemolytic anemia with or without thrombocytopenia in gastric cancer.
PubMedID- 21295897 We report the first case to our knowledge of a patient who developed an acute decrease in kidney function, nonimmune microangiopathic hemolytic anemia with schistocytes, and thrombocytopenia after 4 intravitreal injections of ranibizumab.
PubMedID- 23943710 A congenital or acquired deficiency of adamts-13 can result in accumulation of the ultralarge vwf multimers leading to microangiopathic thromboses and severe thrombocytopenia with resultant hemolytic anemia and thrombotic sequelae.6 in the rare familial forms of ttp, mutations of the adamts-13 gene can be found resulting in significant risk of ttp in pregnancy in affected women.6 acquired ttp is postulated to be secondary to viral infections that trigger production of antibodies targeted against adamts-13.7 women with acquired ttp also have a high risk of recurrence in a subsequent pregnancy.6 it has been proposed that specific proteins found in the placental circulation serve as antigens that trigger maternal antibody production against adamts-13.
PubMedID- 22374533 It is important to suspect ttp when hemolytic anemia with thrombocytopenia is observed, and to check the activity and antigen of adamts13 immediately for the diagnosis.
PubMedID- 23842487 Background: hemolytic anemia with thrombocytopenia and schistocytosis is suggestive of thrombotic thrombocytopenic purpura (ttp).
PubMedID- 22929300 59. thrombocytopenia associated with mechanical hemolytic anemia should suggest tma, even in the absence of organ failure (strong agreement).
PubMedID- 20056203 Result(s): both patients developed a very rare complication after surgery of severe thrombocytopenia with microangiopathic hemolytic anemia leading to acute renal failure.
PubMedID- 23961497 The overall impression on hematological examination was hemolytic anemia with thrombocytopenia and reactive marrow hyperplasia.
PubMedID- 23827373 Hemolytic and uremic syndrome (hus) is a classical form of thrombotic microangiopathies characterized by the association of hemolytic anemia with schizocytes, thrombocytopenia, and acute renal failure.

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