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PedAM

Pediatric Disease Annotations & Medicines




Disease severe combined immunodeficiency
Symptom C0023418|leukemia
Sentences 3
PubMedID- 25635465 have used b43-pap immunotoxin plus cyclophosphamide to successfully treat human leukemia in mice with severe combined immunodeficiency (scid).
PubMedID- 22135288 It was reported that several patients developed t-cell leukemia during treatment of x-linked severe combined immunodeficiency (scid-x1), because of viral integration near the proto-oncogenes lmo2, bmi1 and ccnd2 (23,26).
PubMedID- 22368270 Nonobese diabetic/severe combined immunodeficiency mice transplanted with leukemia cells from patients before and during sorafenib resistance recapitulated the clinical results.

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