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PedAM

Pediatric Disease Annotations & Medicines




Disease septicemia
Symptom C0027947|neutropenia
Sentences 36
PubMedID- 21894754 A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency.
PubMedID- 23259255 Efficacy and safety of doripenem for sepsis with neutropenia in japanese patients with hematologic diseases.
PubMedID- 21572797 On day 21, she developed acute renal failure and severe sepsis with neutropenia and was managed by the infectious diseases physician.
PubMedID- 24777705 The treatment of sepsis in neutropenia with i.v.
PubMedID- 25301539 Febrile neutropenia-induced sepsis resulted in the death of 1 patient with significant medical comorbidities; 2 other patients died of comorbidities unrelated to their cancer or treatment.
PubMedID- 23746966 Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea.
PubMedID- 23056733 sepsis and pneumonia owing to neutropenia and respiratory distress may occur5.
PubMedID- 25861347 However, neutropenia combined with sepsis could lead to life-threatening.
PubMedID- 25970182 Atg side effect (long-standing neutropenia leading to sepsis) was considered as cause of death in one patient.
PubMedID- 23248429 She developed febrile neutropenia with sepsis during the third week of induction.
PubMedID- 23205339 One had gastric perforation resulting in death , one had cardiac complications , and one had sepsis with neutropenia 7.25 months later .
PubMedID- 23192498 Independent factors associated with initial cr-gnb were profound neutropenia, the presence of severe sepsis and active haematological disease.
PubMedID- 21687537 The patient had multiple episodes of febrile neutropenia with concomitant sepsis producing delays and dose reduction of chemotherapy.
PubMedID- 22367386 Background and aim: early diagnosis of sepsis in children with febrile neutropenia and cancer still remains a challenge for modern medicine because of lack of specific laboratory markers and clinical signs especially at the beginning of the infection.
PubMedID- 25031945 The one patient in the 3.6-mg/kg cohort experienced febrile neutropenia complicated with presumed sepsis, which ultimately resulted in unexpected mortality (grade 5 toxicity) 14 days after receiving the initial dose (younes et al., 2010).
PubMedID- 23090499 Two patients died after consolidation from sepsis in neutropenia on days 74 and 77, respectively, after start of induction therapy (table 4).
PubMedID- 21906359 Antibiotic therapy must be initiated immediately in febrile patients with neutropenia, especially when criteria of severe sepsis are met .
PubMedID- 24027727 estimates suggest that when sepsis is associated with severe neutropenia, mortality exceeds 50%.
PubMedID- 23799041 The exclusion criteria included presence of infection with human immunodeficiency virus and/or aids, neutropenia not attributable to sepsis, treatment with immunosuppressive therapies (use of systemic glucocorticoids equivalent to 0.5 mg or more of prednisone/kg/day within a month prior to admission to the icu; treatment with other major immunosuppressive drugs; or radiation therapy), pregnancy, or blood diseases (such as hematological tumors).
PubMedID- 22828545 The study concluded that before routine use of rhg-csf in neonatal sepsis with neutropenia further large scale, multi-centre, randomized, placebo controlled trial are needed to validate the beneficial effect.
PubMedID- 22426640 Dlt was defined as any grade 4 toxicities, grade 3 neutropenia or the occurrence of neutropenic sepsis, grade 3 thrombocytopenia or any grade 3 toxicities that did not return to grade1/2 within 3 weeks, except for alopecia.
PubMedID- 21808399 These include studies on its use in determining bacterial sepsis in children with febrile neutropenia, its use as a marker of renal parenchymal infection and its use as a marker of the severity of acute pancreatitis.
PubMedID- 23989947 Dose-limiting toxicities (dlts) were evaluated during cycle 1 and were defined as follows: anc <0.5 × 109 per l for >5 days; grade 3 neutropenia with fever (⩾38.5 °c), sepsis or other severe infection; platelet count <25.0 × 109 per l; any other grade 3/4 nonhaematological adverse event (ae) suspected to be treatment related (except for nausea/vomiting without an optimal antiemetic regimen, hypersensitivity reactions and nonclinically relevant biochemical abnormalities); and any delays in the administration of a subsequent plitidepsin dose exceeding 2 weeks, or omissions of the infusions scheduled on days 8 and 15 because of treatment-related aes.
PubMedID- 20207442 Unanticipated grade 3 hepatotoxitity, hyponatremia, mental status changes, grade 3 and 4 thrombocytopenia, and grade 4 neutropenia with sepsis were observed.
PubMedID- 24535696 Maltophilia pneumonia or sepsis because of chemotherapy-induced neutropenia or immunodeficiency.
PubMedID- 22467971 Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a labrador retriever dog.
PubMedID- 23738899 However, the disease relapsed only two months later and he succumbed to sepsis in neutropenia upon salvage immunotherapy with lenalidomide in preparation for allogeneic stem cell transplantation.
PubMedID- 25918250 Adverse events were graded according to the national cancer institute common terminology criteria for adverse events (ctcae), version 3.0. dlt was defined as any grade 4 toxicity (except for alopecia, or vomiting in the absence of adequate prophylaxis), fever or sepsis concurrent with grade 3-4 neutropenia, symptomatic thrombocytopenia (hemorrhage), any grade 3 cardiotoxicity and any toxicity requiring a treatment delay longer than 15 days.
PubMedID- 21489333 Moreover, as g-csf is often applied in induction-chemotherapy-induced neutropenia, the role of neutropenia-related sepsis in the included trials remains unclear.
PubMedID- 21074176 Preeclampsia, neutropenia, and risk of fungal sepsis in preterm very low birth weight infants.
PubMedID- 24983551 Serum lactate as a biomarker of severe sepsis in children with cancer, neutropenia and fever.
PubMedID- 22633505 In premature infants, early-onset neutropenia is correlated with sepsis, maternal hypertension, intrauterine growth restriction, severe asphyxia, and periventricular haemorrhage, and might be associated with an increase in the incidence of early-onset sepsis, nosocomial infection, and candida colonisation.
PubMedID- 23915833 Among the several factors that contribute to a higher risk of sepsis complications in patients with cancer, chemotherapy-associated neutropenia is probably the single-most important one .
PubMedID- 22592515 Conclusions: of three markers potentially useful for diagnosing bacterial sepsis in children with fever and neutropenia, pct had comparable diagnostic accuracy to crp.
PubMedID- 23935969 The third one, a 57-year old patient in group a, died from sepsis associated with febrile neutropenia and diarrhea after the completion of the third cycle.
PubMedID- 26065059 Patients The guideline development group (gdg) recognises the importance of distinguishing uncomplicated neutropenic fever from neutropenia with severe sepsis and shock, and indeed septic shock can occur without fever.

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