PedAM
Pediatric Disease Annotations & Medicines
| Disease | septicemia |
| Symptom | C0021079|immunosuppression |
| Sentences | 21 |
| PubMedID- 21713197 | The exact sequence of events that result in immunosuppression and lead to sepsis after burn injury, remains yet unknown. |
| PubMedID- 24387680 | Another recently recognized mechanism of immunosuppression in sepsis is t cell exhaustion 3. |
| PubMedID- 21982068 | Background: sepsis-induced immunosuppression has long been considered a factor in late mortality of patients with sepsis. |
| PubMedID- 25992320 | The complexity of the septic syndrome comprises immunological aspects - i.e., sepsis induced immunosuppression - but is not restricted to this fact in modern concepts. |
| PubMedID- 22884251 | Background: although sepsis-induced immunosuppression has long been considered to be a factor in the late mortality of patients with sepsis, little is known about regulatory t cell (treg)-mediated immunosuppression and the effect of polymyxin b-immobilized fiber (pmx-f) on sepsis-induced immunosuppression. |
| PubMedID- 21349174 | This immunosuppression in sepsis is clinically manifest by cutaneous anergy, hypothermia, leucopenia, susceptibility to infection, and failure to clear infection . |
| PubMedID- 24189082 | Poor response to meningococcal vaccination has been reported in two patients with renal transplants on immunosuppression, one of whom developed meningococcal septicaemia which responded to prompt resuscitation and empiric antibiotic treatment.58 subsequent repeat vaccination, including a different conjugate vaccine preparation, also failed to induce immunity.58 a further transplant patient had waning but protective titres to meningococcus c vaccination.59 therefore, if eculizumab becomes used more widely to facilitate renal transplantation for patients with underlying ahus, there needs to be an awareness of the potential for complication by meningococcal disease despite prior vaccination. |
| PubMedID- 21939638 | sepsis induced immunosuppression is a major factor in the host's susceptibility to nosocomial infections and candida albicans accounts for a growing number of these. |
| PubMedID- 24572114 | sepsis-induced immunosuppression is a new paradigm in sepsis pathophysiology. |
| PubMedID- 25976762 | Prior surgery associated with previous abdominal cancer treatment may have been responsible for the observed increased risk of early postoperative death in these patients.34 additionally, these early deaths may have been indirectly related to the increased risk of sepsis arising from immunosuppression from prior cancer treatment. |
| PubMedID- 20652004 | Conclusions: gm-csf treatment for sepsis-induced immunosuppression induces a moderate but only transient increase in systemic hmgb-1 levels. |
| PubMedID- 24693464 | immunosuppression in sepsis has been also identified in post-mortem studies of patients who died of sepsis . |
| PubMedID- 21129935 | Immunological tools to detect sepsis-induced immunosuppression are now available, and novel immunoadjuvants are in development to re-establish immune competence in sepsis patients. |
| PubMedID- 23071440 | Apoptosis of splenic lymphocytes plays a role in the immunosuppression associated with sepsis . |
| PubMedID- 24269692 | Background: sepsis is associated with severe immunosuppression, evidenced by loss and dysfunction of cd3(+) lymphocytes and gammadelta-tcr(+) t-cells. |
| PubMedID- 23663657 | Conclusions: immuno-adjuvant therapy with anti-pd-1, anti-pd-l1 and anti-ctla-4 antibodies reverse sepsis-induced immunosuppression and improve survival in fungal sepsis.the present results are consistent with previous studies showing that blockade of pd-1 and ctla-4 improves survival in bacterial sepsis.thus, immuno-adjuvant therapy represents a novel approach to sepsis and may have broad applicability in the disorder.given the relative safety of anti-pd-1 antibody in cancer clinical trials to date, therapy with anti-pd-1 in patients with life-threatening sepsis who have demonstrable immunosuppression should be strongly considered. |
| PubMedID- 24950549 | Antibiotics are not usually required unless there is evidence of cellulitis, systemic sepsis or in patients with pre-existing immunosuppression (7). |
| PubMedID- 22615556 | For example, despite the potential ability to limit pro-inflammatory cytokine production, endotoxin tolerance is responsible for the induction of immunosuppression in patients with sepsis shock, and this suppression leads to increased incidence to secondary infections and mortality . |
| PubMedID- 24904669 | These bio-chemical, flow cytometric, and immunohistochemical findings are consistent with the hypothesis that immunosuppression occurs in patients with sepsis . |
| PubMedID- 20151106 | Clear evidence of immunosuppression in sepsis comes from studies showing hyporesponsiveness of immunocompetent cells to bacterial agents . |
| PubMedID- 25887317 | “the cytokine storm”), increasing evidence supports an emerging hypothesis that the immunosuppression following the development of early sepsis contributes significantly to later complications of organ failure and mortality in sepsis . |
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