PedAM
Pediatric Disease Annotations & Medicines
| Disease | pulmonary hypertension |
| Symptom | C0856169|endothelial dysfunction |
| Sentences | 7 |
| PubMedID- 20345850 | The endothelin system is activated in severe hypertension (stage 2), heart failure and primary pulmonary hypertension, and is associated with vascular remodelling, endothelial dysfunction, cardiovascular fibrosis and extended atherosclerosis. |
| PubMedID- 24015332 | For instance, if microparticles-carried to the vasculature by the blood or generated locally-do contribute to the endothelial dysfunction of pulmonary hypertension they may provide a new therapeutic target leading to a better patient prognosis. |
| PubMedID- 22440720 | Recent studies have demonstrated systemic endothelial dysfunction in adults with pulmonary hypertension; however, adults often have additional comorbidities affecting endothelial function. |
| PubMedID- 22711313 | Bh4 supplementation also has been shown to recouple nos and reverse endothelial dysfunction associated with pulmonary hypertension or following infusion with angiotensin ii or acth . |
| PubMedID- 20950600 | Due to the chemically unstable nature of bh(4), it was hypothesised that oxidatively stable analogues of bh(4) would be able to support no synthesis to improve endothelial dysfunction in pulmonary hypertension. |
| PubMedID- 23129906 | Conclusions: systemic endothelial dysfunction in children with irreversible pulmonary hypertension due to chd was noted but there was no increased risk for atherosclerosis. |
| PubMedID- 25395393 | Absence of the calcium-binding protein, s100a1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis. |
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