PedAM
Pediatric Disease Annotations & Medicines
| Disease | proteinuria |
| Symptom | C0022658|nephropathy |
| Sentences | 69 |
| PubMedID- 22707888 | Although a metaanalysis showed that pde inhibitor reduces proteinuria in patients with diabetic nephropathy, ptx has not been used in patients with diabetic nephropathy . |
| PubMedID- 24159603 | Our observation that acth gel can reduce proteinuria in patients with advanced diabetic nephropathy suggests that the protein lowering effects of acth may be independent of its anti-inflammatory properties and possibly involve stabilization of podocyte function through activation of mcr-1 receptors . |
| PubMedID- 24707402 | Before the eradication therapy the mean proteinuria of patients with mn, iga nephropathy and fsgs were 2.42 ± 3.24 g/day, 2.12 ± 1.63 g/day and 1.80 ± 1.32 g/day, respectively. |
| PubMedID- 26558120 | He also had prior nephrotic range proteinuria documented with secondary membranous nephropathy of unspecified etiology. |
| PubMedID- 25621126 | In human diabetic nephropathy with proteinuria, sirt1 was downregulated and claudin1 was upregulated. |
| PubMedID- 23814426 | 1 proteinuria is usually associated with membranous nephropathy, and it is rarely associated with minimal change disease or mesangioproliferative glomerulonephritis. |
| PubMedID- 24273653 | There have been reports of mmp inhibitors, specifically doxycycline, successfully reducing proteinuria in patients with diabetic nephropathy (aggarwal et al. |
| PubMedID- 24886340 | Remission of proteinuria in patients with idiopathic membranous nephropathy and nephrotic syndrome according to fe-igg level. |
| PubMedID- 24282787 | C1q nephropathy usually presents with proteinuria or full-blown nephrotic syndrome. |
| PubMedID- 22456060 | Some iga nephropathy (igan) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy with renin- angiotensin system blockade. |
| PubMedID- 22399858 | 33 in addition, some arbs may be more effective than others in reducing proteinuria in patients with diabetic nephropathy despite providing similar reductions in bp.34 nevertheless, the main renoprotective actions of arbs in general are largely mediated by their effects on bp.9 interestingly, the fda has not extended a general claim of nephroprotective benefits to all molecules in the arb class despite the fact that all approved arbs inhibit at1 signaling and lower bp. |
| PubMedID- 23543049 | Methods: we genotyped 3 snps, rs7583877 in aff3, rs12437854 in the rgma-mctp2 locus and rs7588550 in erbb4, for 2,300 japanese patients with type 2 diabetes initial study, 1,055 nephropathy cases with overt proteinuria or with end-stage renal disease (esrd) and 1,245 control patients with normoalbuminuria. |
| PubMedID- 23434935 | Activation of protein kinase c (pkc) has been implicated in the pathogenesis of diabetic nephropathy with proteinuria and peritubular extracellular matrix production. |
| PubMedID- 25102693 | Artemisinin ameliorated proteinuria in rats with adriamycin-induced nephropathy through regulating nephrin and podocin expressions. |
| PubMedID- 20682692 | Multiple clinical trials have shown that blockade of the renin-angiotensin system (ras) can improve renal function in late diabetic nephropathy in patients with proteinuria, diabetes, and reduced glomerular filtration rate (2–4). |
| PubMedID- 23197956 | Successful treatment of adult iga nephropathy with nephrotic-level proteinuria by combination therapy including long-term coadministration of mizoribine. |
| PubMedID- 24174881 | Acthar® gel (acthar; questcor pharmaceuticals, inc., union city, ca, usa) has recently been shown to induce remission, defined as stabilization or improvement of renal function (by estimated glomerular filtration rate) and resolution of proteinuria, in patients with idiopathic membranous nephropathy.7 herein, we describe a case in which 13 months of treatment with acthar resulted in a sustained remission of membranous nephropathy in a patient with refractory disease. |
| PubMedID- 23977072 | A report from a study carried out in china stated that, among iga nephropathy patients with proteinuria of <0.4 g/day, gfr ≥90 ml/min/1.73 m2, and normotension, proteinuria increased in 46% of patients, hypertension was developed in 38%, and renal insufficiency in 24% during the mean follow-up duration of 111 months . |
| PubMedID- 26289088 | Background: sometimes, acute and progressive proteinuria increases occur in patients with iga nephropathy (igan) after favorable long-term clinical courses of >10 years, but their clinical and histological characteristics are not well understood. |
| PubMedID- 24317123 | In this study, patient with minimal change nephrotic syndrome and membranous nephropathy had lower levels of mcp-1 suggesting that proteinuria in and of itself was not associated with increased urinary mcp-1 levels and that activation of resident tubular or endothelial cells and interstitial infiltrates is needed for mcp-1 expression (29). |
| PubMedID- 20110666 | The tg ren2 rat develops nephropathy with proteinuria, increased renal angiotensin ii levels and oxidative stress, and ptc remodeling. |
| PubMedID- 23049672 | Oral calcitriol treatment reduced proteinuria in patients with iga nephropathy . |
| PubMedID- 19605553 | The zucker fatty rats, a widely studied model of obesity and insulin resistance, exhibit glomerular hypertrophy, thickening of basement membranes and diffuse expansion of the glomerular mesangial matrix that resemble some of the histologic changes seen in diabetic nephropathy with proteinuria . |
| PubMedID- 23557791 | Aims: both steroid pulse (sp) monotherapy and the combination of tonsillectomy and sp therapy (tsp) are effective for achieving clinical remission (cr), defined as negative hematuria and proteinuria, in patients with iga nephropathy (igan). |
| PubMedID- 22086123 | Tsp significantly increased the probability of cr in iga nephropathy patients with minimal proteinuria (table 5). |
| PubMedID- 20799970 | A more accurate evaluation of different aspects of scd nephropathy, emphasizing proteinuria and hyperfiltration, needs to be developed in children in order to detect early renal alteration . |
| PubMedID- 23502465 | Reported a down-regulation of nestin expression in fsgs, mn and iga nephropathy with proteinuria, and the glomerular nestin expression levels correlated inversely with the 24-hour urine protein results . |
| PubMedID- 26089878 | We conducted a randomized, double-blind, placebo-controlled study of dong-a university nephrology outpatients between june 2009 and october 2010. nineteen diabetic nephropathy patients, with a proteinuria level > 0.3 g/day and undergoing treatment with acei or arb for at least 6 months, were included. |
| PubMedID- 22865594 | Fk506 alleviates proteinuria in rats with adriamycin-induced nephropathy by down-regulating trpc6 and can expression. |
| PubMedID- 22759247 | In a recent study high dose cholecalciferol, showed a reduction in proteinuria in patients with diabetic nephropathy on ras blockade . |
| PubMedID- 25476525 | Methods: we performed a genome-wide association study using 1000 genomes-based imputation to compare type 1 diabetic nephropathy cases with proteinuria and with or without renal failure with control patients who have had diabetes for more than 15 years and no evidence of renal disease. |
| PubMedID- 26239462 | Urinary ngal levels also correlated with the degree of proteinuria in patients with iga nephropathy and membranous nephropathy . |
| PubMedID- 22803087 | These patients were characterized by oxidative stress, diabetic nephropathy with associated proteinuria, and impairment of water excretion, electrolyte excretion, and nitrogen excretion in the kidneys. |
| PubMedID- 24721885 | Conclusions: the findings in this cohort and previous studies suggest that rare cases of mild iga nephropathy with nephrotic range proteinuria exhibit a clinical presentation, biopsy findings, treatment response, and outcome more typical of iga nephropathy with superimposed minimal change disease. |
| PubMedID- 23815417 | Background: idiopathic membranous nephropathy (imn) patients with persistent high-grade proteinuria are at the highest risk for developing end-stage renal failure. |
| PubMedID- 23326865 | In two small studies, the addition of aliskiren to arb was shown to decrease proteinuria in subjects with iga nephropathy and various forms of primary glomerulonephritis . |
| PubMedID- 20594038 | The authors measured the extent of foot process effacement in 100 iga nephropathy cases with proteinuria and correlated it with the amount of proteinuria. |
| PubMedID- 20954132 | Conclusion: sirolimus aggravates proteinuria in rats with protein overload nephropathy by damaging podocytes, a barrier of glomerular filtration. |
| PubMedID- 23404305 | Finally, we defined overt nephropathy as the presence of persistent proteinuria, since an elevated urinary albumin excretion due to nondiabetic renal lesions or conditions is not rare. |
| PubMedID- 25922592 | Available evidences indicate that ptx may decrease proteinuria in patients with diabetic nephropathy . |
| PubMedID- 24327929 | Urinary nephrin mrna expression significantly correlated with the degree of proteinuria in patients with diabetic nephropathy, showing that nephrin mrna in the urine could possibly be clinically used as a biomarker to follow glomerulopathy progression in diabetic patients . |
| PubMedID- 23843814 | Diabetic nephropathy with proteinuria, including albuminurinuria, occurs in about 20 – 40 % of diabetics from which a considerable cases may proceed to severe renal failure (2, 3)and also to cardiovascular diseases (4-6). |
| PubMedID- 23380390 | Igm nephropathy presenting with proteinuria, especially nephrotic syndrome, frequently is steroid-dependent or steroidresistant and associated with reaching endstage renal disease after a 15-year follow-up. |
| PubMedID- 26068660 | Initial clinical trials show promise with regard to era effects on reducing proteinuria in patients with diabetic nephropathy (dn) who are already on renin-angiotensin system (ras) blocking agents. |
| PubMedID- 25984202 | C1q nephropathy appears with proteinuria, usually within the nephrotic range. |
| PubMedID- 23560927 | In addition astragalus membranaceus has been shown to improve patients’ proteinuria with idiopathic membranous nephropathy . |
| PubMedID- 22218118 | Renoprotective effects of angiotensin receptor blockers and nac in preventing or reducing of proteinuria in patients with diabetic nephropathy was studied. |
| PubMedID- 23331443 | Conclusion: for early iga nephropathy patients with minimal proteinuria, normal blood pressure, and normal renal function, treatment with 2.5 mg/daily of ramipril for 5 years does not offer any benefit. |
| PubMedID- 21311715 | These observations may provide a mechanistic context to the known protective roles of pparα/γ in kidney diseases, such as diabetic nephropathy, which is associated with proteinuria and compromised expression of megalin. |
| PubMedID- 23741418 | Emerging clinical and animal studies have demonstrated that vitamin d and its analog reduce proteinuria in patients with iga nephropathy , , and animal models such as subtotally nephrectomized model , adriamycin-induced nephropathy , . |
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