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PedAM

Pediatric Disease Annotations & Medicines




Disease primary myelofibrosis
Symptom C0018952|extramedullary hematopoiesis
Sentences 2
PubMedID- 23748344 Moreover in our murine model of mplw515l induced myelofibrosis, treatment with mk-2206 decreased extramedullary hematopoiesis, reduced megakaryocyte expansion in the bone marrow, and reduced the severity of reticulin fibrosis in the marrow without inducing peripheral cytopenias.
PubMedID- 23208557 This mutation has been identified in most polycythemia vera (pv) patients, approximately half of essential thrombocythemia (et) and chronic idiopathic myelofibrosis with extramedullary hematopoiesis (cimf) patients, and in a substantial population of other chronic myeloproliferative disease (cmpd) patients .

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