PedAM
Pediatric Disease Annotations & Medicines
| Disease | primary biliary cirrhosis |
| Symptom | C0008370|cholestasis |
| Sentences | 2 |
| PubMedID- 23311897 | This is in line with previous data since cholestasis in cases of primary biliary cirrhosis or progressive familial intrahepatic cholestasis is associated with reduced oatp1b1 and oatp1b3 expression and the concerted down-regulation of both bile salt uptake transporters is considered as a protective mechanism against hepatocellular injury caused by cytotoxic bile acids. |
| PubMedID- 25688837 | Our findings suggest that bile canalicular lumen expansion might explain the presence of cholestasis in patients with primary biliary cirrhosis and primary sclerosing cholangitis. |
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