PedAM
Pediatric Disease Annotations & Medicines
| Disease | polycythemia |
| Symptom | C1096458|vascular occlusion |
| Sentences | 1 |
| PubMedID- 23152654 | Diminished membrane fluidity of red blood cells plays a role in microvascular occlusion in patients with polycythemia vera.7 in addition, jak2 kinase mutation in patients with polycythemia vera causes abnormal phosphorylation of cd 239 on red blood cells, which allows its ligation with the laminin alpha5 chain on the apical surface of endothelial cells.8 this adhesion has been demonstrated to be strong enough to withstand sheer stresses of postcapillary venules.8 thus, polycythemia vera-associated red blood cell adhesion may be another strong factor in the pathophysiology of venous occlusion.6 considering that both polycythemia vera and interferon are possible influences on vascular occlusion and optic disc edema and the pathophysiology described, we immediately attempted to treat the polycythemia vera empirically with pentoxifylline to increase red blood cell fluidity and the interferon-associated inflammation with prednisone. |
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