PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Symptom | C0036690|sepsis |
| Sentences | 35 |
| PubMedID- 22467971 | Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a labrador retriever dog. |
| PubMedID- 25970182 | Atg side effect (long-standing neutropenia leading to sepsis) was considered as cause of death in one patient. |
| PubMedID- 24027727 | estimates suggest that when sepsis is associated with severe neutropenia, mortality exceeds 50%. |
| PubMedID- 23259255 | These results suggest that drpm is useful for sepsis with neutropenia, though further study may be warranted. |
| PubMedID- 24777705 | Observed a significant higher rate of bacteraemia, potentially resulting in sepsis, in patients with neutropenia <0.5 g/l. |
| PubMedID- 23056733 | sepsis and pneumonia owing to neutropenia and respiratory distress may occur5. |
| PubMedID- 22367386 | The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. |
| PubMedID- 23746966 | Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea. |
| PubMedID- 21687537 | The patient had multiple episodes of febrile neutropenia with concomitant sepsis producing delays and dose reduction of chemotherapy. |
| PubMedID- 22047626 | She experienced numerous hospitalizations for sepsis as a consequence of her neutropenia, with white blood cell counts in the 2000-3000 range and neutrophils less than 5%, hemoglobin of 12.1 gm/dl, and platelet count of 186,000. rheumatoid factor (rf) was 67 iu, and cyclic citrullinated peptide igg antibody (ccp-igg) was > 250 u. anti-nuclear antibodies varied between negative and 1:160 with a homogeneous pattern. |
| PubMedID- 25918250 | Adverse events were graded according to the national cancer institute common terminology criteria for adverse events (ctcae), version 3.0. dlt was defined as any grade 4 toxicity (except for alopecia, or vomiting in the absence of adequate prophylaxis), fever or sepsis concurrent with grade 3-4 neutropenia, symptomatic thrombocytopenia (hemorrhage), any grade 3 cardiotoxicity and any toxicity requiring a treatment delay longer than 15 days. |
| PubMedID- 26107833 | Perinatal asphyxia is understoodas a disorder of impaired gaseous exchange which results in fetal hypoxemia andhypercapnia and can predispose to early-onset sepsis, due to neutropenia and to thereduction of medullary reserves of neutrophils(2,20,22). |
| PubMedID- 23205339 | One had gastric perforation resulting in death , one had cardiac complications , and one had sepsis with neutropenia 7.25 months later . |
| PubMedID- 23738899 | However, the disease relapsed only two months later and he succumbed to sepsis in neutropenia upon salvage immunotherapy with lenalidomide in preparation for allogeneic stem cell transplantation. |
| PubMedID- 26061531 | During sepsis, the reduced number of circulating neutrophils, called neutropenia, is a marker of the disease severity . |
| PubMedID- 23248429 | She developed febrile neutropenia with sepsis during the third week of induction. |
| PubMedID- 23927433 | There are two relevant risks with hcl in transplant patients: life-threatening sepsis due to severe neutropenia and immunosuppression and the risk of graft loss due to either sepsis or deferred immunosuppression. |
| PubMedID- 25031945 | The one patient in the 3.6-mg/kg cohort experienced febrile neutropenia complicated with presumed sepsis, which ultimately resulted in unexpected mortality (grade 5 toxicity) 14 days after receiving the initial dose (younes et al., 2010). |
| PubMedID- 23935969 | The third one, a 57-year old patient in group a, died from sepsis associated with febrile neutropenia and diarrhea after the completion of the third cycle. |
| PubMedID- 25301539 | Febrile neutropenia-induced sepsis resulted in the death of 1 patient with significant medical comorbidities; 2 other patients died of comorbidities unrelated to their cancer or treatment. |
| PubMedID- 21572797 | On day 21, she developed acute renal failure and severe sepsis with neutropenia and was managed by the infectious diseases physician. |
| PubMedID- 26065059 Patients | The guideline development group (gdg) recognises the importance of distinguishing uncomplicated neutropenic fever from neutropenia with severe sepsis and shock, and indeed septic shock can occur without fever. |
| PubMedID- 23799041 | The exclusion criteria included presence of infection with human immunodeficiency virus and/or aids, neutropenia not attributable to sepsis, treatment with immunosuppressive therapies (use of systemic glucocorticoids equivalent to 0.5 mg or more of prednisone/kg/day within a month prior to admission to the icu; treatment with other major immunosuppressive drugs; or radiation therapy), pregnancy, or blood diseases (such as hematological tumors). |
| PubMedID- 22633505 | In premature infants, early-onset neutropenia is correlated with sepsis, maternal hypertension, intrauterine growth restriction, severe asphyxia, and periventricular haemorrhage, and might be associated with an increase in the incidence of early-onset sepsis, nosocomial infection, and candida colonisation. |
| PubMedID- 23989947 | Dose-limiting toxicities (dlts) were evaluated during cycle 1 and were defined as follows: anc <0.5 × 109 per l for >5 days; grade 3 neutropenia with fever (⩾38.5 °c), sepsis or other severe infection; platelet count <25.0 × 109 per l; any other grade 3/4 nonhaematological adverse event (ae) suspected to be treatment related (except for nausea/vomiting without an optimal antiemetic regimen, hypersensitivity reactions and nonclinically relevant biochemical abnormalities); and any delays in the administration of a subsequent plitidepsin dose exceeding 2 weeks, or omissions of the infusions scheduled on days 8 and 15 because of treatment-related aes. |
| PubMedID- 20207442 | Unanticipated grade 3 hepatotoxitity, hyponatremia, mental status changes, grade 3 and 4 thrombocytopenia, and grade 4 neutropenia with sepsis were observed. |
| PubMedID- 25861347 | However, neutropenia combined with sepsis could lead to life-threatening. |
| PubMedID- 24535696 | Maltophilia pneumonia or sepsis because of chemotherapy-induced neutropenia or immunodeficiency. |
| PubMedID- 22592515 | Conclusions: of three markers potentially useful for diagnosing bacterial sepsis in children with fever and neutropenia, pct had comparable diagnostic accuracy to crp. |
| PubMedID- 24983551 | Serum lactate as a biomarker of severe sepsis in children with cancer, neutropenia and fever. |
| PubMedID- 23915833 | Among the several factors that contribute to a higher risk of sepsis complications in patients with cancer, chemotherapy-associated neutropenia is probably the single-most important one . |
| PubMedID- 21808399 | These include studies on its use in determining bacterial sepsis in children with febrile neutropenia, its use as a marker of renal parenchymal infection and its use as a marker of the severity of acute pancreatitis. |
| PubMedID- 23090499 | Two patients died after consolidation from sepsis in neutropenia on days 74 and 77, respectively, after start of induction therapy (table 4). |
| PubMedID- 21894754 | A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency. |
| PubMedID- 22828545 | The study concluded that before routine use of rhg-csf in neonatal sepsis with neutropenia further large scale, multi-centre, randomized, placebo controlled trial are needed to validate the beneficial effect. |
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