PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Symptom | C0021311|infections |
| Sentences | 62 |
| PubMedID- 22526211 | Cns patients had severe neutropenia early with frequent infections causing high morbidity and mortality. |
| PubMedID- 21477703 | Gram-positive microorganisms can cause more than half of the bacterial infections in patients with febrile neutropenia, especially bacteremias. |
| PubMedID- 21838907 | neutropenia has been associated with medications, infections, autoimmune diseases, and deficiencies of vitamin b12 and folate 1. |
| PubMedID- 21645173 | In conclusion, rituximab monotherapy with eight weekly infusions is effective in relapsed patients with indolent b-nhl, with acceptable toxicities, including in patients pretreated with rituximab; however, careful monitoring is recommended for infections associated with late-onset neutropenia and hypogammaglobulinemia. |
| PubMedID- 26229484 | This increased proliferation leads to cytopenias, which commonly present with neutropenia leading to infections, thrombocytopenia leading to bleeding complications, and anemia presenting as dyspnea on exertion or at rest.1 the incidence of aml increases with age, with the median age of diagnosis being 65–70 years.2 the cytopenias and the elderly age at presentation complicate the treatment with standard induction, showing very poor survival at 2 years.2 even for patients of younger age (<60 years), the standard-of-care treatments have not changed significantly for the better in the past. |
| PubMedID- 24750901 | The distribution of pitt bacteremia score by infecting species isshown in figure 2, panel a. patients infected with s.mitis were significantly more likely to have a higher pitt bacteremia score (p<0.01).one possible explanation for this observation is that s. mitis strains mainlycaused infections in patients with neutropenia who, compared with patients without neutropenia,might be more likely to have serious infections. |
| PubMedID- 20301655 | Cohen syndrome is characterized by failure to thrive in infancy and childhood; truncal obesity in the teen years; early-onset hypotonia and developmental delays; microcephaly developing during the first year of life; moderate to profound psychomotor retardation; progressive retinochoroidal dystrophy and high myopia; neutropenia in many with recurrent infections and aphthous ulcers in some; a cheerful disposition; joint hypermobility; and characteristic facial features. |
| PubMedID- 22269211 | neutropenia leads to recurrent infections, which are widely documented in the paediatric histories of pn cases and confers upon them a high risk to develop myelodysplasia from the second decade of life, as attested in at least ten c16orf57-positive patients and our patient #17a. |
| PubMedID- 21533222 | Its essential role in sepsis is demonstrated by the recurrence of life-threatening infections in patients with neutropenia or with leukocyte defects . |
| PubMedID- 24608733 | Toxicity and most importantly neutropenia with associated infections were substantial in this study. |
| PubMedID- 22735899 | The remaining 487 patients had infections that were associated with hematologic malignancies, neutropenia, prior exposure to antibiotics, and a decreased cvc removal rate. |
| PubMedID- 23580879 | However, clinical manifestations of infections due to neutropenia may be mild, or even absent, a situation that complicates diagnosis, initial treatment and the follow-up of patients with febrile neutropenia (4,5). |
| PubMedID- 26543528 | A study that evaluated pct in neutropenic hematological patients with mucositis revealed that it represents an important tool to predict the occurrence of major infections in patients with febrile neutropenia, even in the presence of associated complicating conditions, such as mucositis and gvhd.29 a lower threshold value (e.g. |
| PubMedID- 23297642 | Aim: determine the frequency of opportunistic infections among children with immune neutropenia and their mothers. |
| PubMedID- 26118415 | Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction. |
| PubMedID- 26239201 | The study results suggest that daptomycin is an effective therapeutic option for the treatment of a broad range of gram-positive infections in patients with neutropenia, and has a good safety profile. |
| PubMedID- 19664020 | Prolificans infections prove fatal due to persistent neutropenia, and inherited resistance to currently available antifungal drugs. |
| PubMedID- 23928096 | neutropenia can lead to recurrent bacterial infections, which represent an indication of initiating a treatment in most of the cases. |
| PubMedID- 23406481 | Since csfs can only reduce the risk of infections associated with true neutropenia, a low ppv would result in a dilution of the estimated effectiveness of csf prophylaxis and estimated relative differences in effectiveness among agents being studied. |
| PubMedID- 24887148 | neutropenia can lead to life-threatening pyogenic infections whose severity is roughly inversely proportional to the circulating neutrophil counts.when neutropenia is detected, an attempt should be made to establish the etiology, and to distinguish acquired forms (the most frequent, including post viral neutropenia and autoimmune neutropenia) and congenital forms (rare disorders) that may be either isolated or part of a complex rare genetic disease. |
| PubMedID- 23249920 | We describe the incidence and characteristics of infections in children with severe congenital neutropenia (scn), autoimmune neutropenia (an) and idiopathic neutropenia (in). |
| PubMedID- 24280867 | Clinical presentation is dominated by recurrent infections associated with neutropenia, anemia, splenomegaly and autoimmune diseases, particularly rheumatoid arthritis.1, 2, 3, 4 recently, stat3 and stat5 mutations have been detected in t-lgl and in nk-lgl leukemias.5, 6, 7, 8 these somatic mutations, coupled to other intrinsic and extrinsic mechanisms, are likely to induce constitutive activation of the jak/stat pathway thus contributing to maintenance of leukemic lgl survival.9 these findings strongly suggest a common specific pathogenic pattern in t-lgl and nk-lgl leukemias and provide justification for consideration of the same treatment options. |
| PubMedID- 22178143 | neutropenia is often associated with infections, which are major causes of morbidity and mortality in patients with cancer. |
| PubMedID- 26572736 | The cochrane collaboration has published two reviews that aim to appraise the literature for randomized controlled trials on granulocyte transfusions for preventing and treating infections in patients with neutropenia or neutrophil dysfunction . |
| PubMedID- 25595699 | It is approved for the prophylaxis of invasive fungal infections in patients with neutropenia or in haematopoietic stem cell transplant recipients undergoing high-dose immunosuppressive therapy for graft-versus-host disease, and for the treatment of fungal infections. |
| PubMedID- 22563238 | Leukopenia with infections due to neutropenia is rarely found in patients with access to modern health care, but it may complicate extreme hypersplenism and severe disease. |
| PubMedID- 21375212 | During treatment he developed recurrent infections with neutropenia requiring prolonged antibiotics and subsequently developed invasive aspergillosis. |
| PubMedID- 26392781 | This drug has been approved for the prevention of invasive fungal infections in patients with neutropenia and for the treatment of invasive fungal infections in hematopoietic stem cell transplant recipients with graft-versus-host disease. |
| PubMedID- 21353103 | Objective: this meta-analysis was conducted to estimate the effect of systemic antifungal prophylaxis on the frequency of invasive fungal infections in patients with neutropenia and the mortality associated with these infections. |
| PubMedID- 22612259 | No association of neutropenia with more infections was observed. |
| PubMedID- 21879654 | In those patients treatment generally involves preventing infections, managing of febrile neutropenia with broad spectrum antibiotics and antifungal drugs, treatment with recombinant granulocyte hematopoetic factor, rarely transfusions of granulocyte concentrates and intravenous immunoglobulins. |
| PubMedID- 22929189 | The signs of cbl malabsorption are general weakness, slow growth, developmental delays and learning difficulties, dementia, psychological problems, neurodegeneration of the spinal cord, increased rate of infections due to neutropenia, thrombocytopenia, and megaloblastic anemia with lethal consequences if not treated 9. |
| PubMedID- 23295563 | Objective: many bloodstream infections (bsis) occurring in patients with febrile neutropenia following cytotoxic chemotherapy are due to translocation of intestinal microbiota. |
| PubMedID- 21595885 | neutropenia can lead to life-threatening pyogenic infections, acute gingivostomatitis and chronic parodontal disease, and each successive infection may leave permanent sequelae. |
| PubMedID- 24260074 | infections may be due to underlying neutropenia or to transfusional iron overload (5). |
| PubMedID- 25879134 | neutropenia usually presents with recurrent bacterial infections in the first few months of life. |
| PubMedID- 21694893 | Posaconazole has been shown to be more effective than fluconazole or itraconazole for prevention of invasive fungal infections in patients with neutropenia from chemotherapy, leukemia, or myelodysplastic syndrome. |
| PubMedID- 22431927 | The most common adverse events associated to tocilizumab treatment were infections, gastrointestinal symptoms, alteration of liver enzymes, hypercholesterolemia, neutropenia, and infusion reactions. |
| PubMedID- 25654114 | S. maltophilia contaminated central venous catheters and tap water faucets have been implicated in cutaneous and soft tissue infections in patients with neutropenia 2. |
| PubMedID- 24350896 | The frequencies of mutations in asian cases of t-lgl l and clpd-nk were rather high compared with those in reports on western cohorts,5,6 although mutations in addition to these two were also detected in previously reported studies.5,6 several clinical differences have been suggested between asian and western lgl l populations.7,9 in asian populations, prca is the most common hematological complication of t-lgl l and clpd-nk, in contrast to the situation in western countries where rheumatoid arthritis and infections due to neutropenia are more frequent in cases of lgl l.1,17 in a subset of bone marrow failure syndrome such as mds and aa, stat3-mutated t-cell subclones were found, suggesting contributions of stat3-mutated t cells to immune dysregulation in these disorders.18 significant associations of stat3 sh2 domain mutations and prca in the present study further imply their roles in prca, another type of immune-mediated cytopenia. |
| PubMedID- 23730310 | Economic evaluation of posaconazole versus standard azole therapy as prophylaxis against invasive fungal infections in patients with prolonged neutropenia in canada. |
| PubMedID- 24385787 | Early infections are primarily attributed to neutropenia and to microbial invasion due to the breakdown of mucosal barriers. |
| PubMedID- 26258116 | However, g-csf should only be reserved for treating isolated neutropenia with associated infections in patients without significant splenic enlargement in order to avoid possibility of further g-csf induced splenic enlargement and rupture. |
| PubMedID- 23840352 | In contrast, while the other members of the vgs are benign commensals, they have been implicated in infective endocarditis and infections in patients with neutropenia 1. |
| PubMedID- 21486731 | Among patients with malignant haematological diseases, the highest rates of invasive candida infections are found in patients with neutropenia due to induction chemotherapy for acute leukemia or myelodysplastic syndrome and in recipients of allogeneic blood stem cell transplants in the early post-transplant phase and in periods of graft-versus-host disease (gvhd) . |
| PubMedID- 20386986 | Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. |
| PubMedID- 23403504 | infections in individuals with neutropenia can develop into a life threatening condition and therefore require prompt intervention. |
| PubMedID- PMC4126035 | The neutropenia was not associated with infections commonly causing neutropenia or with autoimmune manifestations. |
| PubMedID- 24778999 | Organ infiltration by mc may lead not only to organomegaly, but also to impairment or even loss of organ function and in severe (high grade) disease, bone marrow failure with anemia, thrombocytopenia, and/or recurrent infections (due to neutropenia) may occur. |
| PubMedID- 21618407 | We report the case of a premature male infant with congenital neutropenia, associated with multiple infections, refractory to treatment with granulocyte colony stimulating factor who subsequently underwent matched sibling donor stem-cell transplant. |
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