PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Symptom | C0009450|infection |
| Sentences | 54 |
| PubMedID- 22123661 | Clinical decision rules (cdrs) have been proposed to help predict the risk of severe infection in children with chemotherapy-induced febrile neutropenia, but none has been fully validated. |
| PubMedID- 25729741 | 3gcr-enterobacteriaceae colonization or infection of patients with febrile neutropenia has been reported with increased frequency during the last decade. |
| PubMedID- 23341787 | Four treatmentrelated mortalities occurred that were likely attributable to infection associated with neutropenia, despite weekly treatment wdp. |
| PubMedID- 24829759 | Toxicities were evaluated using national cancer institute’s common terminology criteria for adverse events (ctcae) version 3.0. dose-limiting toxicity (dlt) was designated during treatment course 1 and was defined as any treatment-related clinical adverse event (ae) ≥ grade 3 (except fatigue, fever or transient rigors, nausea or vomiting without antiemetic therapy) or any treatment-related grade 4 (or grade 3 lasting >3 days) laboratory abnormalities (except lymphopenia, leukopenia, transient neutropenia not associated with infection, asymptomatic electrolyte abnormalities and asymptomatic elevations in amylase/lipase). |
| PubMedID- 22935584 | The latter was defined as infection with g3/4 neutropenia or any ivl-related infection. |
| PubMedID- 20960028 | They were defined as drug-related toxicities of grade 3 or 4, including neutropenia (grade 3 with infection, grade 4 for ≥7 days, or febrile for >24 h), thrombocytopenia (grade ≥ 3 with bleeding or grade 4 for ≥7 days), lymphopenia accompanied by an opportunistic infection, or any nonhematologic toxicity of grade 3 or 4 for ≥7 days. |
| PubMedID- 20882524 | We prospectively examined the effect and safety of micafungin against febrile neutropenia with suspected fungal infection in 53 patients (median age, 56 years) who had undergone chemotherapy. |
| PubMedID- 22258705 | Treatment of persistent neutropenia (anc 1,0 × 109/l) in patients with advanced hiv infection in order to reduce the risk of bacterial infections when other therapeutic options are inappropriate. |
| PubMedID- 24616599 | Patient 3 has not had any stomatitis, lymphadenitis or other significant infection despite with severe neutropenia since her early 20s. |
| PubMedID- 25682797 | Moderate neutropenia was not associated with infection, suggesting that current dose reduction guidelines might be too strict. |
| PubMedID- 23634180 | As this evidence suggested a controversial role of diet in the risk of infection in patients with neutropenia, all of our study’s patients received the normal cooked ward diet within a decontaminated environment. |
| PubMedID- 21804612 | Primary graft failure after allogeneic hematopoietic cell transplantation is a life-threatening complication because patients are at a high risk of severe infection owing to prolonged neutropenia after the initial transplantation. |
| PubMedID- 23746966 | Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea. |
| PubMedID- 22204495 | Systemic toxycoses were limited to one cat that experienced a severe neutropenia (grade 3) leading to infection (grade 3) that required hospitalization and antibiotic therapy. |
| PubMedID- 21687649 | The incidence of grade 3 infection (with or without neutropenia) in a calgb study was 2% . |
| PubMedID- 25027517 | Grade 3/4 aes (24%) were mostly related to hematologic toxicity (18%), including dose-dependent neutropenia, both with and without infection, and thrombocytopenia. |
| PubMedID- 22111760 | Third, this study was a retrospective cohort; some limitations such as concurrent infection in patients with febrile neutropenia cannot be completely excluded. |
| PubMedID- 21829769 | In the nsabp-07 trial, infection associated with grade 3/4 neutropenia was seen in 1.0% of patients receiving the fulv regimen and in 2.2% of patients receiving the flox regimen . |
| PubMedID- 25572607 | The patients are at risk of infection and hemorrhage due to neutropenia and thrombocytopenia and suffer from symptoms of anemia. |
| PubMedID- 25517921 | infection due to neutropenia and immunologic impairmentwas still the leading cause of death. |
| PubMedID- 24872818 | While it is an infection occasionally seen in patients with severe neutropenia, it can also be seen in patients with other immune deficiencies. |
| PubMedID- 20178634 | Wiskott-aldrich syndrome is an x-linked disorder characterized by current infection, thrombocytopenia (with small platelets), neutropenia, eczema, high ige levels, a very high prevalence of autoimmunity (including arthropathy, vasculitis, and inflammatory bowel disease) and malignancy. |
| PubMedID- 23307258 | Complicated neutropenia (febrile neutropenia associated with infection) was observed in one (2.1 %) patient only. |
| PubMedID- 23680477 | The most common grade 3 and 4 toxicity was neutropenia, and was associated with infection in only one episode (table 3). |
| PubMedID- 24347836 | While it has been largely accepted that aspergillus species is recognized by cellular receptors and attacked by neutrophils, the radiological and macroscopic findings linking infection with neutropenia remain unconfirmed. |
| PubMedID- 21716917 | 40. regardless of fever, empirical antifungal therapy is recommended in patients who have a history of invasive fungal infection, fungal colonization with neutropenia, symptoms (pleuritic chest pain, blood tinged sputum, or hemoptysis) or signs that suggest newly developed pneumonia, tenderness, or edema around the paranasal sinuses or orbital area, ulcerating lesions or eschar in the nose (a-ii). |
| PubMedID- 21876446 | Background: pegylated-interferon (peg-ifn) and ribavirin (rbv), current standard treatment for hepatitis c virus (hcv) infection, are frequently associated with neutropenia and anemia, leading to high treatment discontinuation rates in hiv/hcv-coinfected patients. |
| PubMedID- 25701436 | Purpose: the study aims to determine the usefulness of procalcitonin (pct) and other blood markers for identification of bacterial infection among patients with febrile neutropenia (fn). |
| PubMedID- 26105201 | Treatment for pediatric acute myeloid leukemia (aml) involves multiple consecutive courses of intensive chemotherapy followed by periods of prolonged severe neutropenia with substantive infection risks. |
| PubMedID- 24396442 | Despite aggressive treatment, the survival rate of the fusarium infection in patients with persistent neutropenia is only 4% (8). |
| PubMedID- 21068482 | For weight > 60 kg, for at least 10 consecutive days), patients in whom neutropenia was associated with a life-threatening infection and those who developed prolonged myelosuppression were excluded. |
| PubMedID- 26451262 | Despite its enormous therapeutic effects, gleevec has very common adverse effects including nausea, fluid retention, lowered resistance to infection (due to neutropenia), and, sometimes, congestive cardiac failure. |
| PubMedID- 21610706 | Dose-limiting toxicity was defined as one of the following adverse events (aes) occurring during cycle 1: grade 4 haematological toxicity; grade 3 neutropenia with infection or fever ⩾38.5°c; grade ⩾3 non-haematological treatment-related toxicity, except toxicities which had not been maximally treated (such as nausea, vomiting and diarrhoea) or that the patient considered tolerable (such as skin rash); confirmed grade 3 qtc prolongation (qtc >500 ms) persisting after correction of other possible causes such as electrolyte imbalance or hypoxia; or inability to receive the next dose of pd 0332991 within 1 week (±1 day) of the last dose because of lack of haematological recovery or prolonged non-haematological toxicity grade ⩾3. |
| PubMedID- 25962114 | There were 9 infection-related admissions, with neutropenia documented in 4 patients, to give an overall 12% rate for patients experiencing febrile neutropenia. |
| PubMedID- 26136138 | Clinical studies have shown that mbl insufficiency is associated with bacterial infection in patients with neutropenia and meningococcal sepsis. |
| PubMedID- 22678568 | Adjusted neutropenia is associated with early serious infection in systemic lupus erythematosus. |
| PubMedID- 23682225 | Among the six patients who stopped treatment for reasons other than disease progression, four did so because of treatment toxicities: pneumonia in one case, grade 4 neutropenia combined with infection in one case and general weakness in two cases. |
| PubMedID- 25929615 | Only few reports have looked into the risk of invasive bacterial infection in children with neutropenia that is not malignancy related. |
| PubMedID- 21971375 | It remains unclear whether neutropenia is associated with infection in chc. |
| PubMedID- 23580872 | Thus, rubor, erythema and pustules may not be seen in neutropenia associated with a cutaneous infection, just as pulmonary infections may fail to present classical signs and symptoms such as cough, dyspnea and characteristic physical examination findings(2). |
| PubMedID- 23975584 | In this report, we describe the current spectrum of infection in patients with malignancies and neutropenia, and emphasize the fact that local and geographic differences are not infrequent. |
| PubMedID- 21838182 | Conclusions: leukopenia consisting of lymphopenia and later neutropenia was common in patients with a/h1n1 infection but was not correlated with disease severity or clinical course, which were similar in both groups. |
| PubMedID- 25804038 | neutropenia with mild infection complications, as well as nonhematologic complications were detected in some cases. |
| PubMedID- 26089739 | Regarding safety issues, the most common grade 3/4 was noncumulative neutropenia (16/20 patients) associated with infection in one patient. |
| PubMedID- 22093149 | Trichosporon fungemia is a rare and fatal fungal infection that occurs in patients with prolonged neutropenia associated with hematologic malignancies. |
| PubMedID- 26525563 | The most common risk factors include recent hospitalization, diabetes mellitus, urinary tract infection, immunosuppression (especially associated with underlying malignancy, neutropenia, and hiv (human immunodeficiency virus)), intravenous drug abuse (ivda), and indwelling catheters . |
| PubMedID- 23423490 | The dlts were defined as follows: (1) grade 4 hematological toxicity, (2) transfusion of platelets for thrombocytopenia, (3) grade 3 neutropenia with infection or fever >38.0 °c, (4) grade 3 or greater non-hematological toxicity with the exception of loss of appetite, nausea, and vomiting, and (5) treatment delay of more than 2 weeks following the last administration of docetaxel. |
| PubMedID- 25959847 | In a further analysis using a multivariate regression to demonstrate the independent predictors of p aeruginosa infection, patients with neutropenia remained as an independent risk factors (odds ratio, 7.48; p < .001). |
| PubMedID- 21949519 | Thus, vsga or sga infants are particularly vulnerable to bleeding with thrombocytopenia or infection associated with neutropenia especially early after birth. |
| PubMedID- 21595885 | neutropenia can lead to life-threatening pyogenic infections, acute gingivostomatitis and chronic parodontal disease, and each successive infection may leave permanent sequelae. |
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