PedAM
Pediatric Disease Annotations & Medicines
| Disease | mastocytosis |
| Symptom | C0002792|anaphylaxis |
| Sentences | 9 |
| PubMedID- 25578100 | Objectives: the aim of the study was to assess the prevalence of anaphylactic reactions and to identify the risk factors for anaphylaxis in patients with mastocytosis depending on the type of the disease. |
| PubMedID- 25345299 | The triggers of anaphylaxis in adults with mastocytosis are numerous, but hymenoptera stings seem to be the most frequent, followed by foods and drugs. |
| PubMedID- 24745682 | Drugs are known triggers of anaphylaxis in patients with mastocytosis even to the association between drug anaphylaxis and mastocytosis does not appear frequently appear. |
| PubMedID- 26139333 | An extensive cutaneous involvement was reported as a risk factor for anaphylaxis, and patients with diffuse cutaneous mastocytosis have been documented to have more severe anaphylaxis symptoms. |
| PubMedID- 24058746 | Mice deficient in stat6 are protected from ova-induced diarrhea and display undetected eosinophilia in the large intestine along with decreased serum ige levels in comparison to wt mice.105 in another study, it was shown that transgenic mice that have mil-9 overexpressed in the enterocytes of the small intestine develop both spontaneous and oral-ag-induced il-4rα- and stat6-dependent intestinal anaphylaxis, which is associated with intestinal mastocytosis, permeability and intravascular leakage.106 similarly, stat6 is required for cytokine-induced eosinophilic esophagitis.107 thus, il-9-mediated mast cell responses and th2 cytokine responses in the intestine elicit inflammation in a stat6-dependent manner. |
| PubMedID- 24782901 | Together with a generally increased risk for anaphylaxis in patients with mastocytosis, and because of individual cases reporting about severe non-allergic drug hypersensitivity reactions in these patients, it has been concluded that mastocytosis patients may be predisposed for nsaid-induced reactions6. |
| PubMedID- 25605272 | Objective: we sought to evaluate the presence of clonal mc disorders in patients seen at our mastocytosis center with hymenoptera sting-induced anaphylaxis, documented hypotension, absence of urticaria pigmentosa, and normal sbt levels. |
| PubMedID- 24164252 | Our findings implicate that all mastocytosis patients with anaphylaxis should undergo detailed allergological assessment before considering treatment and preventive measures. |
| PubMedID- 26036415 | A study that described the trigger factors for anaphylaxis in patients with mastocytosis found that the major precipitating agents were hymenoptera (wasps, bees, ants, and flies) stings (27 %), foods (24 %), and medications (18 %) . |
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