PedAM
Pediatric Disease Annotations & Medicines
| Disease | lynch syndrome |
| Symptom | C0009402|colorectal cancer |
| Sentences | 44 |
| PubMedID- 26473097 | Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives. |
| PubMedID- 21743847 | The american college of gastroenterology found moderate quality evidence for their recommendation that colorectal cancer patients with lynch syndrome undergo colonoscopy every 2 years beginning at age 20-25 and then annually after age 40 9. |
| PubMedID- 25731324 | Effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome. |
| PubMedID- 20010342 | Prevention of metachronous colorectal cancer in patients with lynch syndrome. |
| PubMedID- PMC3288925 | Msi is present in 80-85% of colorectal cancers associated with lynch syndrome. |
| PubMedID- PMC2876284 | This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype. |
| PubMedID- 23896635 | Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers 2. |
| PubMedID- 25910169 | Methods: a decision analytic model was developed which simulated diagnostic and long-term outcomes over a lifetime horizon for colorectal cancer patients with and without lynch syndrome and for relatives of those patients. |
| PubMedID- 23073955 | lynch syndrome in patients with colorectal cancer: finding the needle in the haystack. |
| PubMedID- 21159521 | Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome. |
| PubMedID- 25534380 | Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis. |
| PubMedID- 23508345 | The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized. |
| PubMedID- 24225971 | Molecular tumor testing for lynch syndrome in patients with colorectal cancer. |
| PubMedID- 23470269 | Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age. |
| PubMedID- 25323653 | Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer. |
| PubMedID- 21768580 | Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. |
| PubMedID- 26284327 | The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females. |
| PubMedID- 25142628 | The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%). |
| PubMedID- 24056992 | Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome. |
| PubMedID- 20495877 | Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation. |
| PubMedID- 22056658 | Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer. |
| PubMedID- 20704743 | About 3% of all colorectal cancers is due to lynch syndrome, an autosomal dominant condition caused by germline mutations in one of the dna mismatch repair (mmr) genes, mlh1, msh2, msh6 and pms2 1. |
| PubMedID- 24415879 | Epithelial-mesenchymal transition in colorectal cancer tissue of patients with lynch syndrome. |
| PubMedID- 25794514 | Approximately 3% of colorectal cancers are associated with lynch syndrome. |
| PubMedID- 19957108 | Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome. |
| PubMedID- 22262812 | colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function. |
| PubMedID- 25213040 | Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage. |
| PubMedID- 23073952 | Identification of lynch syndrome among patients with colorectal cancer. |
| PubMedID- 23245329 | Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways. |
| PubMedID- 23125224 | Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients. |
| PubMedID- 24759670 | Some colorectal cancers with lynch syndrome-like pedigrees remain mutation-negative in a dna mismatch repair (mmr) gene analysis . |
| PubMedID- 25816162 | However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation. |
| PubMedID- 20206180 | One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome. |
| PubMedID- 22237445 | Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting. |
| PubMedID- 22175017 | However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome. |
| PubMedID- 23787146 | To establish a diagnosis of lynch syndrome, every patient with colorectal cancer should undergo a detailed family history. |
| PubMedID- 22480969 | Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed. |
| PubMedID- 23733757 | Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc). |
| PubMedID- 25081898 | Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives. |
| PubMedID- 26249337 | Lower prevalence of lynch syndrome in colorectal cancer patients in a japanese hospital-based population. |
| PubMedID- 25754680 | Fertility after young-onset colorectal cancer: a study of subjects with lynch syndrome. |
| PubMedID- 25583420 | Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum. |
| PubMedID- 23598716 | Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study. |
| PubMedID- 22411104 | Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome. |
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