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PedAM

Pediatric Disease Annotations & Medicines




Disease lyme disease
Symptom C0422833|ent symptoms
Sentences 8
PubMedID- 25490690 Summary: patients with persistent symptoms possibly associated with lyme disease often provide a challenge for clinicians.
PubMedID- 21694904 In summary, extensive evidence now shows that persistent symptoms of lyme disease are due to chronic infection with the lyme spirochete in conjunction with other tick-borne coinfections.
PubMedID- 21437061 Furthermore, female predominance has been noted in patients with persistent symptoms of lyme disease.14 gender differences in human disease susceptibility are usually attributed to either physiologic or sociologic causes.
PubMedID- 22853630 Among the remaining patients, 36 (15%) had a history of prior, physician-documented and treated early lyme disease with persistent or recurrent symptoms.
PubMedID- 26385994 Long-term assessment of post-treatment symptoms in patients with culture-confirmed early lyme disease.
PubMedID- 21941449 Numerous studies have documented persistent b. burgdorferi infection in patients with persistent symptoms of neurologic lyme disease following short-course antibiotic therapy.1–4 furthermore, animal models have demonstrated that short-course antibiotic therapy may fail to eradicate the lyme spirochete.24–26 persistent spirochetal infection appears to be a more likely explanation for chronic symptoms of lyme disease than the autoimmune hypotheses that have been postulated but never substantiated, and recent evidence has shed more light on the complex strategies that allow b. burgdorferi to evade both the immune response and antibiotic agents.27–29 the use of prolonged antibiotic therapy to eradicate ongoing spirochetal infection is consistent with the evidence for persistent b. burgdorferi infection outlined in these studies, and our results support this therapeutic approach.
PubMedID- 20670707 Persistent symptoms following treatment of early lyme disease: false hope.
PubMedID- 22922244 Antibiotic retreatment of lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials.

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