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PedAM

Pediatric Disease Annotations & Medicines




Disease liver failure, acute
Symptom C0085584|encephalopathy
Sentences 29
PubMedID- 26195209 Diagnosis and management of hepatic encephalopathy in fulminant hepatic failure.
PubMedID- 24069137 In human, brain edema is a critical component of hepatic encephalopathy associated with acute liver failure .
PubMedID- 25896893 The long-term effects of hepatic encephalopathy in patients with acute liver failure have not been widely examined but those who recover are largely neurologically intact.
PubMedID- 21263362 Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure.
PubMedID- 20673320 A head ct scan frequently demonstrates cerebral edema in acute liver failure patients with advanced-stage hepatic encephalopathy .
PubMedID- 21423375 Brain edema is a critical component of hepatic encephalopathy associated with acute liver failure and such edema appears to be principally due to astrocyte swelling (cytotoxic edema).
PubMedID- 21182490 We investigated the effects of cannabidiol, a non-psychoactive constituent of cannabis sativa with anti-inflammatory properties that activates the 5-hydroxytryptamine receptor 5-ht(1a) , on brain and liver functions in a model of hepatic encephalopathy associated with fulminant hepatic failure induced in mice by thioacetamide.
PubMedID- 26413514 The pathophysiology is attributed to factors, such as cerebral edema, cerebral hemorrhage, hyponatremia, and fulminant hepatic failure with encephalopathy, cerebral anoxia, microcapillary hemorrhage, and release of toxic products .
PubMedID- 22971971 Treatment and course: a hepatic encephalopathy due to acute hepatic failure was diagnosed and a detoxication of ammonemia with lactulose was started immediately.
PubMedID- 20952452 In the course of the intoxication, hemorrhagic gastritis, renal insufficiency and increasing signs of fulminant hepatic failure complicated with coagulopathy and encephalopathy were observed.
PubMedID- 23133760 Type a he describes encephalopathy associated with acute liver failure.
PubMedID- 23573291 Two of these cases did not qualify as dhf by who 1997 criteria: both had no bleeding manifestations (although tourniquet tests were not performed); one developed fulminant hepatic failure with encephalopathy and the other had dengue encephalopathy.
PubMedID- 23724918 A 6-year-old sri lankan girl developed acute liver failure with severe hepatic encephalopathy due to sodium valproate.
PubMedID- 26356634 The mechanism of this modality lies in the removal of toxins that accumulate in hepatic failure and the addition of coagulation factors to correct the coagulopathy from liver injury.102 multiple studies have shown the efficacy of plasma exchange in reducing the level of nitrogenous waste products (ammonia and urea), improving coagulopathy, and improving encephalopathy in patients with acute liver failure.103 other studies have demonstrated that plasma exchange exerts beneficial effects on survival in acute liver failure secondary to acetaminophen dili and in patients with residual liver functional capacity.104 in acute liver failure, other benefits stem from the removal of inflammatory cytokines and effects on regulatory t cells.105 therefore, plasma exchange exerts positive prognostic and survival value over symptomatic treatment alone in cases of acute liver failure secondary to dili.
PubMedID- 20453399 One female patient died from acute hepatic failure associated with encephalopathy after fertilization therapy, while 2 male patients recovered from encephalopathy-free, prolonged hepatic failure after noncompliance with drug therapy.
PubMedID- 20459677 Nguyen tl et al concluded in their study on 45 patients in vietnam, that dhf may cause mild to moderate liver dysfunction in most cases; only some patients may suffer from acute liver failure leading to encephalopathy and death 9.
PubMedID- 21705899 encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.
PubMedID- 25999668 Finally, our results on peripheric and central effects of cbd against toxic effects of cocaine are in agreement with previous results showing that this compound restored both liver and brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure induced in mice by thioacetamide .
PubMedID- 24975240 Frontal electroencephalogram variables are associated with the outcome and stage of hepatic encephalopathy in acute liver failure.
PubMedID- 23559726 The indications for icu admission included ards figure 1, fulminant hepatic failure (fhf) with encephalopathy, shock and seizures table 1.
PubMedID- 24396287 In general, hav infection risk is inversely correlated to sanitation and other socio-economic indicators 21. although japan is one of the developed countries in asia, a universal vaccination program against hav and hbv has not yet been initiated 17. although the present study did not include acute liver failure with hepatic encephalopathy such as fulminant hepatitis a, our study is important because udps analysis of these hav strains reconfirmed that a single source might have caused this outbreak as previously reported 16, suggesting that udps analysis might be a new analytical tool for the source of hepatitis a outbreaks.
PubMedID- 24365344 fulminant hepatic failure presents with a hepatic encephalopathy and may progress to coma and often brain death from cerebral edema.
PubMedID- 20492684 On the other hand, our experience is that serum ammonia concentration does not correlate with the degree of hepatic encephalopathy in patients with acute liver failure occasionally.
PubMedID- 23112401 Provisionally diagnosed of fulminant hepatic failure (acute liver failure-alf) with grade iii encephalopathy, and given his unaffordability for orthotopic liver transplantation (meets king's college criteria), supportive therapy with vitamin-k, albumin, fresh frozen plasma (ffp), dextrose, rifaximin, l-ornithine-l-aspartate and lactulose was started.
PubMedID- 20594263 Conclusions: chronic gm treatment does not have a major effect on hepatic encephalopathy in rats with taa-induced acute liver failure and rats with chronic liver failure induced by common bile duct ligation.
PubMedID- 25277846 There have been few reports of acute liver failure (alf), with encephalopathy and coagulopathy, caused by infiltration of the liver by malignant cells.
PubMedID- 26464569 After a brief initial response to supportive respiratory measures and empiric antimicrobial therapy, he developed multisystemic organ failure, including lactic acidosis, acute liver failure with metabolic encephalopathy, acute kidney injury and worsening pancytopenia dependent on blood and platelet transfusions.
PubMedID- 21372353 Patients were excluded from the study if they had nonhepatic metabolic encephalopathies, severe co morbid conditions (like severe associated lung or cardiac disease) or hepatic encephalopathy due to acute liver failure.
PubMedID- 22825549 On the other hand, the disease entity of “acute hepatitis severe type” was excluded from the footnote of the present criteria, because patients classified under such a disease entity can also be diagnosed as having “acute liver failure without hepatic encephalopathy”.table 4classification of hepatic encephalopathy in adult patients according to the grade of hepatic coma proposed by the inuyama symposium in 1972; from reference grade of comapsychiatric disordersreference itemsiinversion of sleep patterneuphoria and/or occasional depressionnegligent attitude with shortened attention spanrecognized retrospectively in most casesiidisorientation of time or place and confusioninappropriate behaviors, such as throwing away money or discarding items of valueoccasional somnolent tendency; able to open eyes and respond appropriately to questionsmakes impolite remarks, but follows doctors’ instructionsexcitation state and, urinary and fecal incontinence are absent, but flapping tremor is found on physical examinationiiistate of excitation and/or delirium, showing defiant behaviorsomnolent tendency; sleeping most of the timeopens eyes in response to stimulation, but cannot follow the instructions of doctors, except for simple ordersflapping tremor is observed, and the extent of disorientation is severeivcoma; complete loss of consciousnessresponse to painful stimulibrushes off doctor’s hands if touched and/or frowns in response to stimulivdeep comano response to painful stimulitable 5classification of hepatic encephalopathy in pediatric patients and infants according to the grade of hepatic coma as proposed at the 5th workshop on pediatric liver diseases in 1988; from reference grade of comapediatric patientsinfantsilow-spirited from before (seems lethargic compared with previous physical activity level)does not laugh aloudiiobedient attitude with somnolent tendencydisorientation of time or placedoes not laugh even when being played withcannot maintain eye contact with the mother (more than 3 months after birth)iiiopens eyes in response to loud voiceivdoes not wake up in response to painful stimuli, but frowns and/or brushes off the item producing the stimulus with his/her handsvno response to painful stimulitable 6classification of etiologies of acute liver failure modified from the criteria proposed by the intractable liver diseases study group of japan in 2002; from reference i.viral infection 1 hepatitis a virus (hav) 2 hepatitis b virus (hbv)  (1) transient infection  (2) acute exacerbation in hbv carrier   i. inactive carrier, without drug exposure   ii.

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