PedAM
Pediatric Disease Annotations & Medicines
| Disease | liver disease |
| Symptom | C0023890|cirrhosis |
| Sentences | 175 |
| PubMedID- 23369794 | Cholangiopathies frequently lead to biliary fibrosis and cirrhosis with the complications of end-stage liver disease . |
| PubMedID- 21552420 | Alcoholic hepatitis, nonalcoholic steatohepatitis, and viral hepatitis are the 3 major causes of chronic liver diseases, leading to liver fibrosis, cirrhosis, and the end-stage of hepatocellular carcinoma. |
| PubMedID- 21949642 | The latency period for liver cirrhosis, the major category of liver disease mortality, is long, up to 20 y of excessive drinking . |
| PubMedID- 26473344 | Nonalcoholic fatty liver disease (nafld) can lead to cirrhosis, hepatocellular carcinoma, and ultimately death. |
| PubMedID- 23140577 | Hepatitis c virus (hcv) is a hepacivirus that causes chronic liver disease, leading to hepatocellular carcinoma, cirrhosis, and chronic hepatitis in about 3% of the world population. |
| PubMedID- 24625898 | Purpose of review: primary biliary cirrhosis (pbc) can lead to end-stage liver disease and death. |
| PubMedID- 26504859 | In addition it was found that zn levels depend on the severity of liver disease; thus, in patients with decompensated liver cirrhosis, zn concentrations are reduced by up to 75%, this is explained by changes in the protein and amino acid metabolism and by disturbances in intestinal resorption and hepatic zn extraction . |
| PubMedID- 25849950 | Fatty liver disease can lead to steatohepatitis, fibrosis, cirrhosis, and even cancer, which is associated with various complications. |
| PubMedID- 20070500 | Different from western countries where alcoholic cirrhosis constitutes 50–70% of all underlying liver diseases in china, hepatitis b-related aclf (hb-aclf) cases account for more than 80% of aclf cases as a result of the high incidence of chronic hbv infection . |
| PubMedID- 22204909 | Hepatitis c virus (hcv) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (hcc). |
| PubMedID- 22921634 | The diagnosis of asymptomatic cirrhosis in patients with liver disease is of importance to start screening for complications in due time. |
| PubMedID- 23431353 | Hepatic fibrosis is a common pathological process of chronic liver diseases and would lead to cirrhosis, and fuzheng huayu (fzhy) is an effective chinese herbal product against liver fibrosis. |
| PubMedID- 23162602 | Their research has shown high prevalence of viral infection in a1atd-associated chronic liver disease leading to cirrhosis and furthermore to the development of hcc. |
| PubMedID- 23449255 | Chronic alcohol consumption is a leading cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. |
| PubMedID- 26424404 | Consequently, the development of end-stage liver disease (esld) with cirrhosis and hepatocellular carcinoma occurs at a younger age in co-infected individuals . |
| PubMedID- 25710025 | Irrespective of the etiology, persisting liver fibrogenesis is widely recognized as the major driving force for the progression of any form of chronic liver disease (cld) ultimately leading to liver cirrhosis and hepatic failure . |
| PubMedID- 24843757 | The following patients were excluded: (i) patients (n = 378) for whom liver ultrasonography was not carried out, or not available; and (ii) patients (n = 103) with any clinical evidence of cirrhosis or other causes of chronic liver disease (i.e., alcohol intake >20 g/day, viral hepatitis, autoimmune hepatitis, hemochromatosis and use of hepatotoxic medications). |
| PubMedID- 25633908 | Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation. |
| PubMedID- 22916250 | cirrhosis represents the end-stage of any chronic liver disease, characterized by the most advanced stage of fibrosis, distortion of the liver parenchyma associated with septae and nodule formation, altered blood flow and the potential development of liver failure at long term. |
| PubMedID- 20518553 | Liver fibrosis or cirrhosis is one of the representative liver diseases with a high morbidity and mortality worldwide. |
| PubMedID- 25848466 | Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. |
| PubMedID- 24719131 | The diagnosis of liver fibrosis and cirrhosis in patients with chronic liver disease is critical, as cirrhotic patients are at higher risk of developing end stage liver disease, portal hypertension, and hepatocellular carcinoma (hcc).1,2 these sequelae are important causes of morbidity, mortality, and increasing health care costs.3,4 the cumulative incidence of hcc is significantly higher in patients with severe fibrosis than in those with no or mild fibrosis.5 thus, the early detection and accurate staging of hepatic fibrosis or cirrhosis has become a critical issue in practice. |
| PubMedID- 22712870 | Lmwh at 0.7 u anti-xa ml completely inhibited tg in 9/30 cirrhosis patients with more advanced liver disease (child pugh b and c), whereas complete tg abolition was seen in only 1/10 controls. |
| PubMedID- 21694865 | The mean metavir score was 3.8 ± 0.8 (n = 30, minimum 3, maximum 4), consistent with advanced cirrhosis, a typical feature of end-stage liver disease due to ba. |
| PubMedID- 26279293 | Chronic hepatitis c is one of the most important causes of liver disease, leading to cirrhosis, hepatic decompensation and hepatocellular carcinoma. |
| PubMedID- 26121590 | cirrhosis is a consequence of chronic liver diseases, characterized by liver injury, chronic inflammation and finally by progressive substitution of liver parenchyma by scar tissue. |
| PubMedID- 25540037 | The development of chronic hepatitis b virus-mediated liver disease may lead to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma. |
| PubMedID- 22277039 | C p < 0.0001), indication for surgery prevention of bleeding recurrence differed from refractory ascites (p = 0.0001) and the indication to stop acute bleeding (p = 0.026); aetiology of the liver disease patients with alcoholic cirrhosis differed from patients with budd-chiari syndrome (p < 0.0001) and from patients with chronic viral hepatitis (p = 0.024). |
| PubMedID- 25089192 | Obesity is associated with dyslipidemias, hyperinsulinemia and hypertension, increasing risks for premature heart disease and stroke, many cancers, bone and joint problems, sleep apnea, asthma and other breathing problems, gall bladder disease, liver disease leading to cirrhosis, depression and eating disorders, genitourinary problems, pregnancy complications, central nervous system problems and more, many of which are now starting to be seen in children and adolescents.3 these trends are already showing up as increased medical care costs for children and adolescents.4 the overall medical care costs of obesity in the united states already exceed $140 billion per year.5 as a result, the obesity epidemic may be one of the most challenging and serious medical and public health problems of the twenty-first century. |
| PubMedID- 24076416 | However, cirrhosis increases the risk of death and liver disease. |
| PubMedID- 24008520 | Other possible reasons include differences in the causes of the underlying liver diseases, and patients with cirrhosis tending to have higher afp levels than those with chronic hepatitis . |
| PubMedID- 24019010 | It can cause chronic liver disease and lead to liver cirrhosis and cancer 1. |
| PubMedID- 22848841 | The hepatitis c virus (hcv) is one of the most prevalent causes of chronic liver disease worldwide and leads to cirrhosis and hepatocellular carcinoma in a high percentage of carriers .insulin resistance (ir), impaired glucose tolerance, and type 2 diabetes mellitus (dm) are frequent extrahepatic manifestations . |
| PubMedID- 26188836 | Abnormal liver function test results and alterations in serum liver enzyme markers (eg, alanine and aspartate transaminases) may suggest cirrhosis in patients with chronic liver disease; however, they are not definitive. |
| PubMedID- 24786290 | Liver cirrhosis is a result of advanced liver diseases. |
| PubMedID- 23837137 | liver disease, including cirrhosis, is one of the leading causes of morbidity and mortality in korea and ranked the 8th most common cause of death in 2007.1 spontaneous bacterial peritonitis (sbp) is a bacterial infection of the ascitic fluid and is diagnosed based on the following criteria: the presence of more than 250 neutrophils in ascitic fluid, which is not associated with surgery or an intraabdominal origin of infection in liver cirrhosis patients.2,3 sbp is the most common type of infection in hospitalized cirrhotic patients, occurring in about 9% of cases and accounting for about 25% of all infections.4 about 10% of cirrhotic patients with ascites may develop sbp within a year.5 despite the use of sensitive methods, only 39-41% of culture-positive sbp are in korean patients with sbp compared to around 60% in western studies.1,6,7 among positive culture results, both gram positive and negative organisms can be isolated, the more common being gram negative. |
| PubMedID- 25651500 | Liver stiffness measurement (lsm) using te (fibroscan®) is accurate in identifying significant fibrosis, and in particular cirrhosis, in a number of liver diseases (5). |
| PubMedID- 26274335 | Nafld was also defined by clinical diagnosis (cryptogenic cirrhosis, obese-diabetics with cryptogenic liver disease). |
| PubMedID- 21994867 | Since the vast majority of hccs occur on a background of liver disease with or without cirrhosis, it is clear that prognosis does not depend exclusively on tumour-related factors but also on liver function, general health, and other comorbidities of the patient and response to various medical treatments depending on the aetiology 5. |
| PubMedID- 20171943 | Nonalcoholic steatohepatitis patients should undergo periodic evaluation of cardiovascular risk and of advancement of their liver disease; those with nonalcoholic steatohepatitis-cirrhosis should be evaluated for early diagnosis of hepatocellular carcinoma. |
| PubMedID- 20164779 | Conclusion: liver stiffness measurement, 13c-aminopyrine breath test, indocyanine green plasma clearance, and apri score are reliable noninvasive methods for the diagnosis of cirrhosis in patients with chronic liver diseases of various causes, and are also prognostic indicators for the occurrence of severe complications in cirrhotic patients. |
| PubMedID- 25066318 | In these patients, continual inflammatory activity can cause significant fibrosis, cirrhosis, decompensation of the liver disease, or hepatocarcinoma. |
| PubMedID- 24215040 | Conclusion: coffee drinking is associated with a reduced prevalence of cirrhosis in patients with chronic liver disease. |
| PubMedID- 26025214 | Idiopathic non-cirrhotic portal hypertension (incph) is a rare disease characterized by of intrahepatic portal hypertension in the absence of cirrhosis, other causes of liver disease and splanchnic venous thrombosis . |
| PubMedID- 22412837 | Exclusion criteria included cirrhosis, the presence of other liver diseases, diabetes, pregnancy, significant clinical co-morbidities, and the inability to provide informed consent. |
| PubMedID- 23880821 | In addition, we lacked assessment of underlying liver disease, although men with cirrhosis were excluded from the cohort at baseline and associations did not vary over 24 years of follow-up. |
| PubMedID- 23192205 | Objective: the objective of this study was to determine whether arterial enhancement fraction (aef) is associated with the degree of liver fibrosis and cirrhosis in patients with chronic liver disease. |
| PubMedID- 21619386 | Objective: to perform a prospective validation and comparative analysis of two ultrasonographic diagnostic scores of cirrhosis in patients with silent liver disease. |
| PubMedID- 25896480 | Patients with hcv are accompanied by chronic liver disease, which can lead to fibrosis, cirrhosis, and an increased risk of complications including ascites and hepatocellular carcinoma. |
| PubMedID- 26215812 | Ccl4 is a potent hepatotoxin commonly used to induce cirrhosis in mouse models of liver disease , while cisplatin is a chemotherapeutic agent with strong nephrotoxic side effects utilized in mouse models of acute kidney injury (aki) . |