PedAM
Pediatric Disease Annotations & Medicines
| Disease | leukemia |
| Symptom | C1608408|malignant transformation |
| Sentences | 4 |
| PubMedID- 20222966 | Background: adult t cell leukemia results from the malignant transformation of a cd4+ lymphoid clone carrying an integrated htlv-1 provirus that has undergone several oncogenic events over a 30-60 year period of persistent clonal expansion. |
| PubMedID- 23613955 | The reciprocal chromosomal translocation t(9; 22) results in the highly stable, constitutively active tyrosine kinase bcr/abl, which inhibits apoptosis and triggers malignant transformation of chronic myelogenous leukemia (cml). |
| PubMedID- 26206695 | Therefore, we also considered other possibilities such as malignant transformation of the teratoma to leukemia 8 or the genetic vulnerability of hematopoietic tissue itself to chemotherapy in xyy syndrome cases. |
| PubMedID- 24632884 | It is generally accepted that t-cell acute lymphoblastic leukemia (t-all) results from malignant transformation of normal developing t cells in the thymus, the so-called thymocytes. |
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