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PedAM

Pediatric Disease Annotations & Medicines




Disease hypothyroidism
Symptom C1145670|respiratory failure
Sentences 2
PubMedID- 25473574 The mechanisms of type ii respiratory failure due to hypothyroidism include (1) impaired central ventilator responses to hypoxia and hypercapnia; (2) hypoventilation caused by respiratory muscle dysfunction; and (3) obstructive sleep apnea syndrome (osas) 1.
PubMedID- 21867529 Ttf-1 haploinsufficiency secondary to deletions or mono-allelic mutations of the nkx2.1 gene has been recognized as a rare cause of neonatal or infantile respiratory failure, often associated with congenital hypothyroidism and/or benign hereditary chorea , referred to as "brain-lung-thyroid syndrome".

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