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PedAM

Pediatric Disease Annotations & Medicines




Disease hyperuricemia
Symptom C0022658|nephropathy
Sentences 3
PubMedID- 22701621 In this study, we used streptozotocin (stz)-induced diabetic nephropathy model with hyperuricemia and dyslipidemia in rats, and found over-expression of renal inflammasome components nlrp3, apoptosis-associated speck-like protein and caspase-1, resulting in elevation of il-1beta and il-18, with subsequently deteriorated renal injury.
PubMedID- 20215410 In this species, hyperuricemia is associated with gout, nephropathy, and increased cardiovascular disease risk.
PubMedID- 22557752 Lesch–nyhan syndrome is an x-linked recessive disorder of purine metabolites leading to hyperuricemia and hyperuricosuria with consequent nephropathy, and neurological effects such as poor muscle control, choreoathetosis, spasticity, self-mutilation, and mental retardation.

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